Zobrazeno 1 - 10
of 91
pro vyhledávání: '"J A, Beavo"'
Autor:
Maria Heloisa Massola Shimizu, M. Markerink-van Ittersum, W. C. G. van Staveren, J. de Vente, Harry W.M. Steinbusch, J. A. Beavo, J. Glick
Publikováno v:
Journal of Neurocytology. 31:729-741
In this study, we report the cloning of the rat cGMP-specific phosphodiesterase type 9 (PDE9A) and its localization in rat and mouse brain by non-radioactive in situ hybridization. Rat PDE9A was 97.6% identical to mouse PDE9A1 and showed 92.1% simila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9435eedab7feaddf8de7eeaa4edbe092
https://doi.org/10.1023/a:1025704031210
https://doi.org/10.1023/a:1025704031210
Autor:
Sergei D. Rybalkin, J A Beavo
Publikováno v:
Biochemical Society Transactions. 24:1005-1009
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c477680d486e87504d264f0a360c8ac
https://doi.org/10.1042/bst0241005
https://doi.org/10.1042/bst0241005
Autor:
K. Ferguson, Michael Riggs, T. Michaeli, Linda Rodgers, K. Loughney, T. Martins, T. J. Bloom, Michael Wigler, J. A. Beavo
Publikováno v:
Scopus-Elsevier
We have established a highly sensitive functional screen for the isolation of cDNAs encoding cAMP phosphodiesterases (PDEs) by complementation of defects in a Saccharomyces cerevisiae strain lacking both endogenous cAMP PDE genes, PDE1 and PDE2. Thre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74e08d8e1098ffebf0c0e8560357bf0
https://doi.org/10.1016/s0021-9258(18)31474-1
https://doi.org/10.1016/s0021-9258(18)31474-1
Publikováno v:
Journal of Biological Chemistry. 268:645-652
We have isolated a 2287-bp cDNA encoding the 61-kDa calmodulin-stimulated cyclic nucleotide phosphodiesterase (CaM PDE) from a bovine brain library. A large open reading frame within the cDNA encodes a 530-residue polypeptide which is identical to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e29b503be02c5abdc63843f7b10b1014
https://doi.org/10.1016/s0021-9258(18)54200-9
https://doi.org/10.1016/s0021-9258(18)54200-9
Autor:
J. K. Bentley, Harry Charbonneau, Dalia Seger, William K. Sonnenburg, Ann Kadlecek, Jeffrey P. Novack, C H Sherbert, J A Beavo
Publikováno v:
Scopus-Elsevier
Partially degenerate oligonucleotides based on peptide sequence were used to isolate cDNA to a 63-kDa bovine brain calmodulin-stimulated phosphodiesterase (CaM-PDE) isozyme. A 412-base pair polymerase chain reaction fragment was obtained and used alo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57c712ed0ebf9d11f0561e2601c3c383
https://doi.org/10.1016/s0021-9258(19)37014-0
https://doi.org/10.1016/s0021-9258(19)37014-0
Autor:
S D Stroop, J A Beavo
Publikováno v:
Journal of Biological Chemistry. 266:23802-23809
Studies of cGMP binding to both the native cyclic GMP-stimulated phosphodiesterase and to two unique isolated chymotryptic fragments lacking the catalytic domain suggest that the enzyme contains two noncatalytic cGMP-binding sites/homodimer. In the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aafd59147b4682345a2e446d8e72fcb8
https://doi.org/10.1016/s0021-9258(18)54354-4
https://doi.org/10.1016/s0021-9258(18)54354-4
Publikováno v:
Journal of Biological Chemistry. 266:17655-17661
We have cloned a 4.2-kilobase pair (kb) cDNA that encodes the cyclic GMP-stimulated phosphodiesterase (cGS PDE) from a bovine adrenal cortex library. The 921-residue polypeptide deduced from the cDNA nucleotide sequence is nearly identical with the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b62e4cc2d0c034c5436dbbc2749f7ff4
https://doi.org/10.1016/s0021-9258(19)47421-8
https://doi.org/10.1016/s0021-9258(19)47421-8
Publikováno v:
Journal of Biological Chemistry. 266:136-142
An adrenal cGMP-stimulated phosphodiesterase (cGS-PDE) has been shown to mediate atrial natriuretic peptide (ANP)-induced reductions in aldosterone secretion and cAMP levels in primary bovine glomerulosa cells. High concentrations of cGS-PDE have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24f78f6253d0426a9c94f24b158ad49b
https://doi.org/10.1016/s0021-9258(18)52413-3
https://doi.org/10.1016/s0021-9258(18)52413-3
Autor:
W C G, van Staveren, J, Glick, M, Markerink-van Ittersum, M, Shimizu, J A, Beavo, H W M, Steinbusch, J, de Vente
Publikováno v:
Journal of neurocytology. 31(8-9)
In this study, we report the cloning of the rat cGMP-specific phosphodiesterase type 9 (PDE9A) and its localization in rat and mouse brain by non-radioactive in situ hybridization. Rat PDE9A was 97.6% identical to mouse PDE9A1 and showed 92.1% simila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d1d5e62ebcdd8ec14df55f8f7df01e3e
https://pubmed.ncbi.nlm.nih.gov/14501210
https://pubmed.ncbi.nlm.nih.gov/14501210
Publikováno v:
Biology of reproduction. 64(6)
Calcium and cyclic nucleotides are second messengers that regulate the development and functional activity of spermatozoa. Calcium/calmodulin-dependent phosphodiesterases (CaM-PDEs) are abundant in testicular cells and in mature spermatozoa and provi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::01f80a92bcf680890939b09161bb7ede
https://pubmed.ncbi.nlm.nih.gov/11369604
https://pubmed.ncbi.nlm.nih.gov/11369604