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Retroviral transfer of the hENT2 nucleoside transporter cDNA confers broad-spectrum antifolate resistance in murine bone marrow cells

Autor: D H, Patel, J A, Allay, J A, Belt, B P, Sorrentino

Publikováno v: Blood. 95(7)

Antifolate drugs such as methotrexate are commonly used in cancer chemotherapy. It may be possible to increase the antitumor activity of antifolates by the coadministration of drugs that inhibit nucleoside transport, thereby blocking the capacity of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4fb0749339cb256b0f381c2253faeffe
https://pubmed.ncbi.nlm.nih.gov/10733507

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High levels of lymphoid expression of enhanced green fluorescent protein in nonhuman primates transplanted with cytokine-mobilized peripheral blood CD34(+) cells

Autor: R E, Donahue, R P, Wersto, J A, Allay, B A, Agricola, M E, Metzger, A W, Nienhuis, D A, Persons, B P, Sorrentino

Publikováno v: Blood. 95(2)

We have used a murine retrovirus vector containing an enhanced green fluorescent protein complimentary DNA (EGFP cDNA) to dynamically follow vector-expressing cells in the peripheral blood (PB) of transplanted rhesus macaques. Cytokine mobilized CD34

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2852bc398c30b23c09c0d40c40e226e7
https://pubmed.ncbi.nlm.nih.gov/10627448

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In vivo selection of hematopoietic stem cells transduced with DHFR-expressing retroviral vectors

Autor: B P, Sorrentino, J A, Allay, R L, Blakley

Publikováno v: Progress in experimental tumor research. 36

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::02192311aa970415ef1f7be3b83f2805
https://pubmed.ncbi.nlm.nih.gov/10386071

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Enforced expression of the GATA-2 transcription factor blocks normal hematopoiesis

Autor: D A, Persons, J A, Allay, E R, Allay, R A, Ashmun, D, Orlic, S M, Jane, J M, Cunningham, A W, Nienhuis

Publikováno v: Blood. 93(2)

The zinc finger transcription factor GATA-2 is highly expressed in immature hematopoietic cells and declines with blood cell maturation. To investigate its role in normal adult hematopoiesis, a bicistronic retroviral vector encoding GATA-2 and the gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fcbd5df67f5935b4b84457aec54eb2a4
https://pubmed.ncbi.nlm.nih.gov/9885210

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Sensitization of hematopoietic stem and progenitor cells to trimetrexate using nucleoside transport inhibitors

Autor: J A, Allay, H T, Spencer, S L, Wilkinson, J A, Belt, R L, Blakley, B P, Sorrentino

Publikováno v: Blood. 90(9)

Antifolates such as methotrexate (MTX) and trimetrexate (TMTX) are widely used in the treatment of cancer and nonmalignant disorders. Transient, yet sometimes severe myelosuppression is an important limitation to the use of these drugs. It has previo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::abb4a0c91a823c5a81cbbe41a4a316f9
https://pubmed.ncbi.nlm.nih.gov/9345038

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Retroviral-mediated transfer of the green fluorescent protein gene into murine hematopoietic cells facilitates scoring and selection of transduced progenitors in vitro and identification of genetically modified cells in vivo

Autor: D A, Persons, J A, Allay, E R, Allay, R J, Smeyne, R A, Ashmun, B P, Sorrentino, A W, Nienhuis

Publikováno v: Blood. 90(5)

We have investigated the utility of the green fluorescent protein (GFP) to serve as a marker to assess retroviral gene transfer into hematopoietic cells and as a tool to identify and enrich for cells expressing high levels of the vector-encoded trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1d9b26ee2484155198acdf29b4980134
https://pubmed.ncbi.nlm.nih.gov/9292510

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Retroviral-mediated gene transduction of human alkyltransferase complementary DNA confers nitrosourea resistance to human hematopoietic progenitors

Autor: J A, Allay, O N, Koç, B M, Davis, S L, Gerson

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 2(8)

Myelosuppression is the dose-limiting toxicity for nitrosourea chemotherapy due to low levels of the DNA repair protein O6-alkylguanine-DNA alkyltransferase in myeloid precursors. We have shown that high-efficiency myeloproliferative sarcoma virus (v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::30d569a25b69b39a54b898e232c9a8fd
https://pubmed.ncbi.nlm.nih.gov/9816307

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Transfer of drug resistance genes into hematopoietic progenitors to improve chemotherapy tolerance

Autor: O N, Koç, J A, Allay, K, Lee, B M, Davis, J S, Reese, S L, Gerson

Publikováno v: Seminars in oncology. 23(1)

A number of drug resistance genes have been identified that may be useful in gene therapy approaches to ameliorate chemotherapy toxicity. Hematopoietic tissue is the most suitable target for drug resistance gene therapy because myelosuppression is th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ba026d354f9450f62e20211ea1c222a7
https://pubmed.ncbi.nlm.nih.gov/8607032

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Role of DNA repair in resistance to drugs that alkylate O6 of guanine

Autor: O N, Koç, W P, Phillips, K, Lee, L, Liu, N H, Zaidi, J A, Allay, S L, Gerson

Publikováno v: Cancer treatment and research. 87

The mechanism of cytotoxicity of a number of chemotherapeutic agents involves alkylation at the O6 position of guanine, a site that strongly influences cytotoxicity. Repair of these lesions by the alkyltransferase protects from cytotoxicity and is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8ef733de28e3d9d2fb06009271bd921e
https://pubmed.ncbi.nlm.nih.gov/8886451

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Retroviral transduction and expression of the human alkyltransferase cDNA provides nitrosourea resistance to hematopoietic cells

Autor: J A, Allay, L L, Dumenco, O N, Koc, L, Liu, S L, Gerson

Publikováno v: Blood. 85(11)

Myelosuppression is the dose-limiting toxicity for nitrosourea chemotherapy. This toxicity predominantly involves modification of the O6 position of guanine with an alkyl moiety. The enzyme responsible for repair of O6-alkylguanine adducts, O6-alkylg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b3169da8f25c1c75a4cd6bdf7dd38198
https://pubmed.ncbi.nlm.nih.gov/7756667

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