Zobrazeno 1 - 10
of 621
pro vyhledávání: '"J Uitti"'
Autor:
Dhairya A. Lakhani, Xiangzhi Zhou, Shengzhen Tao, Vishal Patel, Sijin Wen, Lela Okromelidze, Elena Greco, Chen Lin, Erin M. Westerhold, Sina Straub, Zbigniew K. Wszolek, Philip W. Tipton, Ryan J. Uitti, Sanjeet S. Grewal, Erik H. Middlebrooks
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Parkinson’s disease (PD) is a prevalent neurodegenerative disorder that presents a diagnostic challenge due to symptom overlap with other disorders. Neuromelanin (NM) imaging is a promising biomarker for PD, but adoption has been limited,
Externí odkaz:
https://doaj.org/article/9dca74a1052e4b18aca938d6ee5defdd
Autor:
Rebecca R. Valentino, Chloe Ramnarine, Michael G. Heckman, Patrick W. Johnson, Alexandra I. Soto-Beasley, Ronald L. Walton, Shunsuke Koga, Koji Kasanuki, Melissa E. Murray, Ryan J. Uitti, Julie A. Fields, Hugo Botha, Vijay K. Ramanan, Kejal Kantarci, Val J. Lowe, Clifford R. Jack, Nilufer Ertekin-Taner, Rodolfo Savica, Jonathan Graff-Radford, Ronald C. Petersen, Joseph E. Parisi, R. Ross Reichard, Neill R. Graff-Radford, Tanis J. Ferman, Bradley F. Boeve, Zbigniew K. Wszolek, Dennis W. Dickson, Owen A. Ross
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-15 (2022)
Abstract Dementia with Lewy bodies (DLB) is clinically diagnosed when patients develop dementia less than a year after parkinsonism onset. Age is the primary risk factor for DLB and mitochondrial health influences ageing through effective oxidative p
Externí odkaz:
https://doaj.org/article/3ccebbf408344276a4d599bfa2266e82
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
The heterogeneity of Parkinson’s disease (PD) has been recognized since its description by James Parkinson over 200 years ago. The complexity of motor and non-motor PD manifestations has led to many attempts of PD subtyping with different prognosti
Externí odkaz:
https://doaj.org/article/87c8436c9a154ef4a4b6f63693d79163
Autor:
Rebecca R. Valentino, Shunsuke Koga, Ronald L. Walton, Alexandra I. Soto-Beasley, Naomi Kouri, Michael A. DeTure, Melissa E. Murray, Patrick W. Johnson, Ronald C. Petersen, Bradley F. Boeve, Ryan J. Uitti, Zbigniew K. Wszolek, Dennis W. Dickson, Owen A. Ross, Michael G. Heckman
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-9 (2020)
Abstract The microtubule-associated protein tau (MAPT) H1 haplotype is the strongest genetic risk factor for corticobasal degeneration (CBD). However, the specific H1 subhaplotype association is not well defined, and it is not clear whether any MAPT
Externí odkaz:
https://doaj.org/article/5fc49e4942314738a9faeede291c7e80
Autor:
Samantha L. Strickland, Hélène Morel, Christian Prusinski, Mariet Allen, Tulsi A. Patel, Minerva M. Carrasquillo, Olivia J. Conway, Sarah J. Lincoln, Joseph S. Reddy, Thuy Nguyen, Kimberly G. Malphrus, Alexandra I. Soto, Ronald L. Walton, Julia E. Crook, Melissa E. Murray, Bradley F. Boeve, Ronald C. Petersen, John A. Lucas, Tanis J. Ferman, Ryan J. Uitti, Zbigniew K. Wszolek, Owen A. Ross, Neill R. Graff-Radford, Dennis W. Dickson, Nilüfer Ertekin-Taner
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-12 (2020)
Abstract Missense variants ABI3_rs616338-T and PLCG2_rs72824905-G were previously associated with elevated or reduced risk of Alzheimer’s disease (AD), respectively. Despite reports of associations with other neurodegenerative diseases, there are f
Externí odkaz:
https://doaj.org/article/5c704262ecff4fcc9493c0136aee83c4
Autor:
Angela B. Deutschlander, Takuya Konno, Alexandra I. Soto‐Beasley, Ronald L. Walton, Jay A. vanGerpen, Ryan J. Uitti, Michael G. Heckman, Zbigniew K. Wszolek, Owen A. Ross
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 9, Pp 1557-1563 (2020)
Abstract Objective To determine whether distinct microtubule‐associated protein tau MAPT H1 subhaplotypes are associated with clinical and demographic features in Parkinson’s disease. Methods A retrospective cohort study included 855 unrelated Ca
Externí odkaz:
https://doaj.org/article/eec7aa4a232c4597b7bd767393b8c22b
Autor:
Rebecca R. Valentino, Nikoleta Tamvaka, Michael G. Heckman, Patrick W. Johnson, Alexandra I. Soto-Beasley, Ronald L. Walton, Shunsuke Koga, Ryan J. Uitti, Zbigniew K. Wszolek, Dennis W. Dickson, Owen A. Ross
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-11 (2020)
Abstract Mitochondrial health is important in ageing and dysfunctional oxidative phosphorylation (OXPHOS) accelerates ageing and influences neurodegeneration. Mitochondrial DNA (mtDNA) codes for vital OXPHOS subunits and mtDNA background has been ass
Externí odkaz:
https://doaj.org/article/41a930b15db74bc3bbf3b57ab6921724
Autor:
Erik H. Middlebrooks, Lela Okromelidze, Joshua K. Wong, Robert S. Eisinger, Mathew R. Burns, Ayushi Jain, Hsin-Pin Lin, Jun Yu, Enrico Opri, Andreas Horn, Lukas L. Goede, Kelly D. Foote, Michael S. Okun, Alfredo Quiñones-Hinojosa, Ryan J. Uitti, Sanjeet S. Grewal, Takashi Tsuboi
Publikováno v:
NeuroImage: Clinical, Vol 32, Iss , Pp 102846- (2021)
Background and purpose: Deep brain stimulation (DBS) is the most common surgical treatment for essential tremor (ET), yet there is variation in outcome and stimulation targets. This study seeks to consolidate proposed stimulation “sweet spots,” a
Externí odkaz:
https://doaj.org/article/956ad0ac20594e2db58476839b4746af
Autor:
Olivia J Conway, Minerva M Carrasquillo, Xue Wang, Jenny M Bredenberg, Joseph S Reddy, Samantha L Strickland, Curtis S Younkin, Jeremy D Burgess, Mariet Allen, Sarah J Lincoln, Thuy Nguyen, Kimberly G Malphrus, Alexandra I Soto, Ronald L Walton, Bradley F Boeve, Ronald C Petersen, John A Lucas, Tanis J Ferman, William P Cheshire, Jay A van Gerpen, Ryan J Uitti, Zbigniew K Wszolek, Owen A Ross, Dennis W Dickson, Neill R Graff-Radford, Nilüfer Ertekin-Taner
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-12 (2018)
Abstract Background Rare coding variants ABI3_rs616338-T and PLCG2_rs72824905-G were identified as risk or protective factors, respectively, for Alzheimer’s disease (AD). Methods We tested the association of these variants with five neurodegenerati
Externí odkaz:
https://doaj.org/article/26aae77c26cb4a6c9e381ff00070adea
Autor:
Monica Y. Sanchez-Contreras, Naomi Kouri, Casey N. Cook, Daniel J. Serie, Michael G. Heckman, NiCole A. Finch, Richard J. Caselli, Ryan J. Uitti, Zbigniew K. Wszolek, Neill Graff-Radford, Leonard Petrucelli, Li-San Wang, Gerard D. Schellenberg, Dennis W. Dickson, Rosa Rademakers, Owen A. Ross
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-10 (2018)
Abstract Background Progressive supranuclear palsy (PSP) is a parkinsonian neurodegenerative tauopathy affecting brain regions involved in motor function, including the basal ganglia, diencephalon and brainstem. While PSP is largely considered to be
Externí odkaz:
https://doaj.org/article/e855fad797a54c078bf1a17639f6a8fc