An orally available Cav2.2 calcium channel inhibitor for the treatment of neuropathic pain.

Autor: Kutzsche, Janine, Guzman, Gustavo A., Willuweit, Antje, Kletke, Olaf, Wollert, Esther, Gering, Ian, Jürgens, Dagmar, Breitkreutz, Jörg, Stark, Holger, Beck‐Sickinger, Annette G., Klöcker, Nikolaj, Hidalgo, Patricia, Willbold, Dieter

Publikováno v: British Journal of Pharmacology; Jun2024, Vol. 181 Issue 12, p1734-1756, 23p

Safety and pharmacokinetics of the orally available antiprionic compound PRI-002: A single and multiple ascending dose phase I study

Autor: Kutzsche, Janine, Jürgens, Dagmar, Willuweit, Antje, Adermann, Knut, Fuchs, Carola, Simons, Stefanie, Windisch, Manfred, Hümpel, Michael, Rossberg, Wolfgang, Wolzt, Michael, Willbold, Dieter

Publikováno v: Alzheimer's & dementia / Translational research & clinical interventions Translational research & clinical interventions [...] 6(1), e12001 (2020). doi:10.1002/trc2.12001
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)
Alzheimer's & Dementia : Translational Research & Clinical Interventions

Introduction PRI‐002 is an orally available anti–amyloid beta (Aβ) prionic compound developed for direct disassembly of toxic Aβ oligomers relevant to Alzheimer's disease. Methods Two placebo‐controlled clinical phase I trials with oral dosin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1d153c392c54f863530c6a982549567a
https://pubmed.ncbi.nlm.nih.gov/32211506

D-peptides developed to be therapeutically active against beta-amyloid oligomers show promising pharmakokinetic properties

Autor: Hofmann, Leonie, Jiang, Nan, Post, Julia, Kutzsche, Janine, Jürgens, Dagmar, Langen, Karl-Josef, Willuweit, Antje, Willbold, Dieter

Publikováno v: 12th International Conference on Alzheimer's and Parkinson's Diseases, AD/PD 2015, Nice, France, 2015-03-18-2015-03-22

see attachment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3364::aea7b252c59a4440719a737dd5fab86b
https://hdl.handle.net/2128/9158

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EXPLORING A POTENTIALLY DIFFERENT OR ADDITIONAL MOA FOR THE CLINICAL STAGE COMPOUND PRI-002

Autor: Willbold, Dieter, Kutzsche, Janine, Schemmert, Sarah, Willuweit, Antje, Jürgens, Dagmar

Publikováno v: In Alzheimer's & Dementia: The Journal of the Alzheimer's Association July 2019 15(7) Supplement:P1589-P1589