Zobrazeno 1 - 10
of 238
pro vyhledávání: '"Jürgen Weiß"'
Autor:
Raquel Fernando, Anastasia V. Shindyapina, Mario Ost, Didac Santesmasses, Yan Hu, Alexander Tyshkovskiy, Sun Hee Yim, Jürgen Weiss, Vadim N. Gladyshev, Tilman Grune, José Pedro Castro
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Skeletal muscle aging is characterized by the loss of muscle mass, strength and function, mainly attributed to the atrophy of glycolytic fibers. Underlying mechanisms driving the skeletal muscle functional impairment are yet to be elucidated
Externí odkaz:
https://doaj.org/article/b1e477911453427b854cf104b5383a76
Autor:
Sofiya Gancheva, Meriem Ouni, Tomas Jelenik, Chrysi Koliaki, Julia Szendroedi, Frederico G. S. Toledo, Daniel F. Markgraf, Dominik H. Pesta, Lucia Mastrototaro, Elisabetta De Filippo, Christian Herder, Markus Jähnert, Jürgen Weiss, Klaus Strassburger, Matthias Schlensak, Annette Schürmann, Michael Roden
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Externí odkaz:
https://doaj.org/article/f6d5f2f9d8a742059cd874a669fa63d2
E96V Mutation in the Kdelr3 Gene Is Associated with Type 2 Diabetes Susceptibility in Obese NZO Mice
Autor:
Delsi Altenhofen, Jenny Minh-An Khuong, Tanja Kuhn, Sandra Lebek, Sarah Görigk, Katharina Kaiser, Christian Binsch, Kerstin Griess, Birgit Knebel, Bengt-Frederik Belgardt, Sandra Cames, Samaneh Eickelschulte, Torben Stermann, Axel Rasche, Ralf Herwig, Jürgen Weiss, Heike Vogel, Annette Schürmann, Alexandra Chadt, Hadi Al-Hasani
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 845 (2023)
Type 2 diabetes (T2D) represents a multifactorial metabolic disease with a strong genetic predisposition. Despite elaborate efforts in identifying the genetic variants determining individual susceptibility towards T2D, the majority of genetic factors
Externí odkaz:
https://doaj.org/article/44ad1a367d59404983c913b62385a243
Autor:
Sofiya Gancheva, Meriem Ouni, Tomas Jelenik, Chrysi Koliaki, Julia Szendroedi, Frederico G. S. Toledo, Daniel F. Markgraf, Dominik H. Pesta, Lucia Mastrototaro, Elisabetta De Filippo, Christian Herder, Markus Jähnert, Jürgen Weiss, Klaus Strassburger, Matthias Schlensak, Annette Schürmann, Michael Roden
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Surgical weight-loss interventions improve insulin sensitivity via incompletely understood mechanisms. Here the authors assess skeletal muscle epigenetic changes in individuals with obesity following metabolic surgery and compare them with data from
Externí odkaz:
https://doaj.org/article/44616f302acf47298a6eeb0b5e82df35
Autor:
Kristina Wardelmann, Sabine Blümel, Michaela Rath, Eugenia Alfine, Chantal Chudoba, Mareike Schell, Weikang Cai, Robert Hauffe, Kathrin Warnke, Tanina Flore, Katrin Ritter, Jürgen Weiß, C. Ronald Kahn, André Kleinridders
Publikováno v:
Molecular Metabolism, Vol 21, Iss , Pp 68-81 (2019)
Objective: Insulin action in the brain controls metabolism and brain function, which is linked to proper mitochondrial function. Conversely, brain insulin resistance associates with mitochondrial stress and metabolic and neurodegenerative diseases. I
Externí odkaz:
https://doaj.org/article/7c9d14609d4c4b8591384c45fafcc306
Autor:
Martin Kragl, Rajib Schubert, Haiko Karsjens, Silke Otter, Barbara Bartosinska, Kay Jeruschke, Jürgen Weiss, Chunguang Chen, David Alsteens, Oliver Kuss, Stephan Speier, Daniel Eberhard, Daniel J. Müller, Eckhard Lammert
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Vasculature is denser in soft than in stiff tissues. Kragl et al. suggest a mechanistic link between biomechanical tissue properties and vascularization by showing that integrin-linked kinase reduces the contractile forces of the cell cortex in endoc
Externí odkaz:
https://doaj.org/article/3882207bac40498da5c5335ea5cae3b0
Autor:
Kristina Wardelmann, Michaela Rath, José Pedro Castro, Sabine Blümel, Mareike Schell, Robert Hauffe, Fabian Schumacher, Tanina Flore, Katrin Ritter, Andreas Wernitz, Toru Hosoi, Koichiro Ozawa, Burkhard Kleuser, Jürgen Weiß, Annette Schürmann, André Kleinridders
Publikováno v:
Antioxidants, Vol 10, Iss 5, p 711 (2021)
Mitochondria are critical for hypothalamic function and regulators of metabolism. Hypothalamic mitochondrial dysfunction with decreased mitochondrial chaperone expression is present in type 2 diabetes (T2D). Recently, we demonstrated that a dysregula
Externí odkaz:
https://doaj.org/article/9db7b1040f554f3f80b1b7f6dd84a90e
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 14, p 3405 (2019)
Bacteria colonize most of the human body, and the female genital tract is not an exception. While the existence of a vaginal microbiota has been well established, the upper genital tract has been considered a sterile environment, with a general assum
Externí odkaz:
https://doaj.org/article/3c89810bcb2c43df8b1550ab2e0bd79f
Autor:
Deepak Jain, Gesine Weber, Daniel Eberhard, Amir E Mehana, Jan Eglinger, Alena Welters, Barbara Bartosinska, Kay Jeruschke, Jürgen Weiss, Günter Päth, Hiroyoshi Ariga, Jochen Seufert, Eckhard Lammert
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138535 (2015)
A hallmark feature of type 1 and type 2 diabetes mellitus is the progressive dysfunction and loss of insulin-producing pancreatic beta cells, and inflammatory cytokines are known to trigger beta cell death. Here we asked whether the anti-oxidant prot
Externí odkaz:
https://doaj.org/article/136f15e82e414e7d85364738b91d57d0
Autor:
Stefanie Jeruschke, Kay Jeruschke, Andrew DiStasio, Sinem Karaterzi, Anja K Büscher, Perihan Nalbant, Ludger Klein-Hitpass, Peter F Hoyer, Jürgen Weiss, Rolf W Stottmann, Stefanie Weber
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137043 (2015)
Glomerular podocytes are highly differentiated cells that are key components of the kidney filtration units. The podocyte cytoskeleton builds the basis for the dynamic podocyte cytoarchitecture and plays a central role for proper podocyte function. R
Externí odkaz:
https://doaj.org/article/a717350a9c5046bfa105ee797e497590