Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jürgen Soutschek"'
Autor:
K. Narayanannair Jayaprakash, Maria Frank-Kamenetsky, Daniel G. Anderson, Robert Langer, Yupeng Fan, Tracy Zimmermann, Muthiah Manoharan, Ingo Röhl, Kevin Fitzgerald, Timothy Racie, Martin Maier, Christina Gamba-Vitalo, Jürgen Soutschek, Akin Akinc, Norma N. Anderson, Lubomir Nechev, Pamela Tan, Muthusamy Jayaraman, Gang Wang, Philipp Hadwiger, Jay D. Horton, Klaus Charisse, Victor Koteliansky, Aldo Grefhorst, David Butler, Matthias John, Antonin de Fougerolles, Robert Dorkin, Timothy Read, Birgit Bramlage, Hans-Peter Vornlocher, Jamie Wong, Kallanthottathil G. Rajeev
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 105(33), 11915-11920. National Academy of Sciences
Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates low density lipoprotein receptor (LDLR) protein levels and function. Loss of PCSK9 increases LDLR levels in liver and reduces plasma LDL cholesterol (LDLc), whereas excess PCSK9 activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c0eef01dd5bd57cc9c0e254fce8aa5
https://doi.org/10.1073/pnas.0805434105
https://doi.org/10.1073/pnas.0805434105
Autor:
Markus Müller, Doris Losert, Hans-Peter Vornlocher, Anke Geick, Barbara Pratscher, Volker Wacheck, Jürgen Soutschek
Publikováno v:
Anti-Cancer Drugs. 18:755-761
The antiapoptotic protein Bcl-2 contributes to a more chemoresistant phenotype of nonsmall cell lung cancer and therefore serves as an important target for novel anticancer strategies. Interestingly, docetaxel as a standard of care for treatment of n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ab4178539380566cfdcf7094aa536c
https://doi.org/10.1097/cad.0b013e3280adc8c8
https://doi.org/10.1097/cad.0b013e3280adc8c8
Autor:
Ivanka Toudjarska, Jürgen Soutschek, Vandana Sood, Kevin McClintock, Akin Akinc, Birgit Bramlage, Matthew N. Fedoruk, Timothy Racie, Adam Judge, Ian MacLachlan, Hans-Peter Vornlocher, Lorne R. Palmer, Lloyd Jeffs, Kieu Lam, Sumi Shanmugam, William Zedalis, Tracy Zimmermann, Ingo Röhl, Matthias John, Ed Yaworski, Jens Harborth, Amy C.H. Lee, Muthiah Manoharan, Stephan Seiffert, James Heyes, David Bumcrot, Amanda J. Wheat, Victor Koteliansky, Lubomir Nechev
Publikováno v:
Nature. 441:111-114
The opportunity to harness the RNA interference (RNAi) pathway to silence disease-causing genes holds great promise for the development of therapeutics directed against targets that are otherwise not addressable with current medicines. Although there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf5bcd46f67e5d2c5a34ff185d98a71
https://doi.org/10.1038/nature04688
https://doi.org/10.1038/nature04688
Autor:
Jürgen Soutschek, Günther K.H. Zupanc
Publikováno v:
Developmental Brain Research. 97:279-286
While involvement of programmed cell death (apoptosis) in embryogenesis is well established, only very little is known about this phenomenon in later stages of development. Based primarily on indirect evidence, it has been proposed that during postem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ba89cf64396d9456b2bd0b875e7db9
https://doi.org/10.1016/s0165-3806(96)00145-9
https://doi.org/10.1016/s0165-3806(96)00145-9
Autor:
Jürgen Soutschek, Günther K.H. Zupanc
Publikováno v:
Neuroscience Letters. 202:133-136
Like many species of teleost fish, the gymnotiform Apteronotus leptorhynchus displays a high degree of proliferative activity in a large number of brain regions during adulthood. One of these regions is the central posterior/prepacemaker nucleus (CP/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1541e216cdd8d911ffa453af52b2f9b8
https://doi.org/10.1016/0304-3940(95)12231-1
https://doi.org/10.1016/0304-3940(95)12231-1
Autor:
Liat Haklai-Topper, Helena Sabanay, Oliver Hobert, Jürgen Soutschek, Jochen Scheel, Elior Peles
Publikováno v:
Gene expression patterns : GEP. 11(1-2)
The neurexin superfamily is a group of transmembrane molecules mediating cell-cell contacts and generating specialized membranous domains in polarized epithelial and nerves cells. We describe here the domain organization and expression of the entire,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::762702e79e6017a39a03e0d2b2ad4d7d
https://pubmed.ncbi.nlm.nih.gov/21055481
https://pubmed.ncbi.nlm.nih.gov/21055481
Autor:
Eric G. Marcusson, Balkrishen Bhat, George W. Bell, Julie Teruya-Feldstein, Jürgen Soutschek, Ferenc Reinhardt, Li Ma, Elizabeth Pan, Robert A. Weinberg
Publikováno v:
PMC
Nature biotechnology
Nature biotechnology
MicroRNAs (miRNAs) are increasingly implicated in regulating metastasis. Despite progress in silencing miRNAs in normal tissues of rodents and non-human primates, the development of effective approaches for sequence-specific inhibition of miRNAs in f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83bf30a6cc6f33145d6c930f3feda49
http://hdl.handle.net/1721.1/116969
http://hdl.handle.net/1721.1/116969
Autor:
David P. Bartel, Clifford J. Tabin, Edwina McGlinn, Jennifer H. Mansfield, Soraya Yekta, Jürgen Soutschek
Patterning of the vertebrate axial skeleton requires precise spatial and temporal control of Hox gene expression during embryonic development. MicroRNAs (miRNAs) are recently described modulators of gene activity, and members of the miR-196 and miR-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da953bdc5381bf6f08f9a47d75f3858e
https://europepmc.org/articles/PMC2773993/
https://europepmc.org/articles/PMC2773993/
Autor:
Johann Bauersachs, Paolo Galuppo, Stephan Kissler, Thomas Fischer, Thomas Tuschl, Sara H. Rouhanifard, Stefan Engelhardt, Jonathan D. Licht, John T. R. Pena, Markus Bussen, Jürgen Soutschek, Martina U. Muckenthaler, Victor Koteliansky, Carina Gross, Stefan Frantz, Steffen Just, Andreas Rosenwald, Gail R. Martin, M. Albert Basson, Jan Fiedler, Wolfgang Rottbauer, Thomas Thum, Mirco Castoldi
Publikováno v:
Nature. 456(7224)
MicroRNAs comprise a broad class of small non-coding RNAs that control expression of complementary target messenger RNAs. Dysregulation of microRNAs by several mechanisms has been described in various disease states including cardiac disease. Whereas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec47718810b9d215dab8e292aa06c59c
https://pubmed.ncbi.nlm.nih.gov/19043405
https://pubmed.ncbi.nlm.nih.gov/19043405
Autor:
Jason Fuller, Valentina Busini, Naushad Hossain, Muthiah Manoharan, Andreas Zumbuehl, Timothy Racie, Rene Alvarez, Ivanka Toudjarska, Todd Borland, Kallanthottathil G. Rajeev, Jürgen Soutschek, Matthias John, Rainer Constien, Tracy Zimmermann, Dinah W.Y. Sah, Victor Koteliansky, K. Narayanannair Jayaprakash, Antonin de Fougerolles, Anna Borodovsky, Robert Langer, Akin Akinc, Elizaveta S. Leshchiner, June Qin, Denitza Raitcheva, Daniel G. Anderson, Michael S. Goldberg, Sergio Bacallado, David N. Nguyen, J. Robert Dorkin, Hans-Peter Vornlocher, Lubomir Nechev, Muthusamy Jayaraman
Publikováno v:
Nature Biotechnology, Vol. 26, No 5 (2008) pp. 561-569
Nature Biotechnology
Nature Biotechnology
The safe and effective delivery of RNA interference (RNAi) therapeutics remains an important challenge for clinical development. The diversity of current delivery materials remains limited, in part because of their slow, multi-step syntheses. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb1e02aa83371950ef1de530b3e00bc
http://hdl.handle.net/11311/513099
http://hdl.handle.net/11311/513099