Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Jürgen Siekmann"'
Publikováno v:
Vox Sanguinis. 117:27-38
BACKGROUND AND OBJECTIVES Assessment of plasma quality often focuses on the common safety tests for minimizing the risk of transmitting blood-borne pathogens. Little attention is paid to the possible quality attributes that ensure a consistent bioche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f880bbbe0547cfb3c2ddcdbf7bc1157
https://doi.org/10.1111/vox.13118
https://doi.org/10.1111/vox.13118
Publikováno v:
Vox sanguinis. 117(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da273611ba9d86554d55d9203d99c64
https://pubmed.ncbi.nlm.nih.gov/34110626
https://pubmed.ncbi.nlm.nih.gov/34110626
Autor:
Amr S. Abu Lila, Rosalía Agusti, Sahar Awwad, Carsten Behrens, Mary J. Bossard, Gunda Brandenburg, Steve Brocchini, Jens Buchardt, Chris Caster, Victor R. de la Rosa, Rosa M. de Lederkremer, Celine Derunes, Nehal E. Elsadek, Elaine L. Ferguson, Marc A. Gauthier, M. Eugenia Giorgi, Kenneth Grabstein, Andrea A. Greschner, Antonella Grigoletto, Richard Hoogenboom, Tatsuhiro Ishida, Waliul Islam, Nandini V. Katre, Hanieh Khalili, Ralf Krähmer, Michael J. LaBarre, Frank Leenders, Gary Li, Kenneth W. Locke, Hiroshi Maeda, Daniel C. Maneval, Katia Maso, Mann Muhsin, Natalie Winblade Nairn, Steffen Nock, Gianfranco Pasut, Christina Picken, Sabine Poppenborg, Christoph Radcke, Sybille Sauter, Ondrej Sedlacek, Rose E. Sekulovich, Kurt D. Shanebeck, Jürgen Siekmann, Joana Stokniene, David W. Thomas, Curtis B. Thompson, Peter L. Turecek, Mathieu Varache, María J. Vicent, Aijun Wang, Julia Wittmann, Ahlem Zaghmi, Samuel Zalipsky, Mire Zloh, Linglong Zou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5499b541259ce8ea55013fa36b35449
https://doi.org/10.1016/b978-0-444-64081-9.01002-0
https://doi.org/10.1016/b978-0-444-64081-9.01002-0
Autor:
Jürgen Siekmann, Peter Turecek
A process for manufacturing of a polysialylated recombinant coagulation factor VIII (PSA-rFVIII) based on the full-length rFVIII product ADVATE (octocog alfa) has been developed by Baxter/Baxalta. For conjugation with rFVIII, a 20 kDa aminooxy-PSA re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96936e8cd2536269d76f4f096b123fe2
https://doi.org/10.1016/b978-0-444-64081-9.00020-6
https://doi.org/10.1016/b978-0-444-64081-9.00020-6
Autor:
Peter Turecek, Jürgen Siekmann
Polyethylene glycol (PEG) is an inert amphiphilic polymer in contrast to ethylene glycol oxide, which is commonly known as a toxic compound used for synthesis of PEG. A consequence of its low reactivity is that PEG does not exhibit toxicity in humans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1b520c310b6af089d2e9ac38835244d
https://doi.org/10.1016/b978-0-444-64081-9.00004-8
https://doi.org/10.1016/b978-0-444-64081-9.00004-8
Autor:
Peter Turecek, Jürgen Siekmann
During the last 28 years, a variety of PEGylated products have been introduced to the market. From 2015 onward, the list also contains PEGylated proteins derived from human plasma or their recombinant analogues. The first product brought to the marke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c648dcb085f22b6945aeba2102cda25b
https://doi.org/10.1016/b978-0-444-64081-9.00008-5
https://doi.org/10.1016/b978-0-444-64081-9.00008-5
Publikováno v:
Journal of pharmaceutical sciences. 109(2)
Measurement of modified biologic including coagulation factors with extended half-life obtained, for example, by polysialylation pose an analytical challenge especially if both biological activity and presence of modification have to be determined. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::360ac54b7d40a9530b844306e0d66c84
https://pubmed.ncbi.nlm.nih.gov/31628921
https://pubmed.ncbi.nlm.nih.gov/31628921
Autor:
Neil Ravenscroft, Umesh Shaligram, Christina M. Szabo, Jürgen Siekmann, Paul Kosma, Zhenqing Zhang, Paul Sanders, G. Joseph Ray
Publikováno v:
Bioconjugate Chemistry. 25:665-676
Polysialic acid (PSA) is a high molecular weight glycan composed of repeat units of α(2→8) linked 5-N-acetyl-neuraminic acid. Mild periodate oxidation of PSA selectively targets the end sialic acid ring containing three adjacent alcohols generatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a874b678ea33b2869d35d11dadbe7b1e
https://doi.org/10.1021/bc400456g
https://doi.org/10.1021/bc400456g
Autor:
Paul Kosma, Christina M. Szabo, Mikhail V. Gerasimov, Jürgen Siekmann, Richard Scheinecker, G. Joseph Ray, Zhenqing Zhang
Publikováno v:
Bioconjugate chemistry. 27(9)
Native polysialic acid (natPSA) is a high-molecular-weight glycan composed of repeat units of α-(2 → 8) linked N-acetylneuraminic acid (Neu5Ac). Mild periodate oxidation of PSA selectively targets the end sialic acid ring containing three adjacent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3db71e5e9756397110140958c4b504f
https://pubmed.ncbi.nlm.nih.gov/27506297
https://pubmed.ncbi.nlm.nih.gov/27506297
Autor:
W. Höllriegl, Jürgen Siekmann, P. Matthiessen, E.-M. Muchitsch, Katalin Varadi, Herbert Gritsch, Gerald Schrenk, Peter Turecek, Artur Mitterer, Friedrich Scheiflinger, A. Schiviz, Hartmut J. Ehrlich, Hans-Peter Prof. Schwarz, M. J. Bossard, M. Graninger, Martin Kaliwoda, M. Purtscher, T. Riley, Hanspeter Rottensteiner
Publikováno v:
Hämostaseologie. 32:S29-S38
SummaryA longer acting recombinant FVIII is expected to serve patients’ demand for a more convenient prophylactic therapy. We have developed BAX 855, a PEGylated form of Baxter’s rFVIII product ADVATE™ based on the ADVATE™ manufacturing proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75353ef4965f18b0fe409870ba8e548f
https://doi.org/10.1055/s-0037-1619772
https://doi.org/10.1055/s-0037-1619772