Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Jürgen Seibel"'
Autor:
Marcel Rühling, Louise Kersting, Fabienne Wagner, Fabian Schumacher, Dominik Wigger, Dominic A. Helmerich, Tom Pfeuffer, Robin Elflein, Christian Kappe, Markus Sauer, Christoph Arenz, Burkhard Kleuser, Thomas Rudel, Martin Fraunholz, Jürgen Seibel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Sphingomyelin is a key molecule of sphingolipid metabolism, and its enzymatic breakdown is associated with various infectious diseases. Here, we introduce trifunctional sphingomyelin derivatives that enable the visualization of sphingomyelin
Externí odkaz:
https://doaj.org/article/49744d45d0a244ae925aa7fb11b17b6c
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 1, Pp 100311- (2023)
Externí odkaz:
https://doaj.org/article/6ac2f37978df48009213a7351da4d819
Autor:
Melissa Zimniak, Luisa Kirschner, Helen Hilpert, Nina Geiger, Olga Danov, Heike Oberwinkler, Maria Steinke, Katherina Sewald, Jürgen Seibel, Jochen Bodem
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-5 (2021)
Abstract To circumvent time-consuming clinical trials, testing whether existing drugs are effective inhibitors of SARS-CoV-2, has led to the discovery of Remdesivir. We decided to follow this path and screened approved medications "off-label" against
Externí odkaz:
https://doaj.org/article/f67e6a08eef542cd9b92d04bc2ae89dd
Autor:
Simon Peters, Lena Kaiser, Julian Fink, Fabian Schumacher, Veronika Perschin, Jan Schlegel, Markus Sauer, Christian Stigloher, Burkhard Kleuser, Jürgen Seibel, Alexandra Schubert-Unkmeir
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Sphingolipids, including ceramides, are a diverse group of structurally related lipids composed of a sphingoid base backbone coupled to a fatty acid side chain and modified terminal hydroxyl group. Recently, it has been shown that sphingolip
Externí odkaz:
https://doaj.org/article/c1934010a96e45aa82d122a97033f33c
Autor:
Ralph Götz, Tobias C. Kunz, Julian Fink, Franziska Solger, Jan Schlegel, Jürgen Seibel, Vera Kozjak-Pavlovic, Thomas Rudel, Markus Sauer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Imaging of lipid bilayers using light microscopy is challenging. Here the authors label cells using a short chain click-compatible ceramide to visualize mammalian and bacterial membranes with expansion microscopy.
Externí odkaz:
https://doaj.org/article/c154212f2c7e45a3b7a9637c386f0c24
Autor:
Judith Lang, Patrick Bohn, Hilal Bhat, Holger Jastrow, Bernd Walkenfort, Feyza Cansiz, Julian Fink, Michael Bauer, Dominik Olszewski, Ana Ramos-Nascimento, Vikas Duhan, Sarah-Kim Friedrich, Katrin Anne Becker, Adalbert Krawczyk, Michael J. Edwards, Andreas Burchert, Magdalena Huber, Justa Friebus-Kardash, Joachim R. Göthert, Cornelia Hardt, Hans Christian Probst, Fabian Schumacher, Karl Köhrer, Burkhard Kleuser, Eduard B. Babiychuk, Beate Sodeik, Jürgen Seibel, Urs F. Greber, Philipp A. Lang, Erich Gulbins, Karl S. Lang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Macrophages are critical in limiting replication of herpes simplex virus type 1 (HSV-1). Here the authors show how acid ceramidase and its enzymatic product sphingosine enable multivesicular bodies to function as an anti-viral mechanism.
Externí odkaz:
https://doaj.org/article/ce87beeac86246829e4b47c4ed971f39
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Externí odkaz:
https://doaj.org/article/8c03fe89f79a4a95ae52a0e0def61e9d
Autor:
Sascha Eder, Claudia Hollmann, Putri Mandasari, Pia Wittmann, Fabian Schumacher, Burkhard Kleuser, Julian Fink, Jürgen Seibel, Jürgen Schneider-Schaulies, Christian Stigloher, Niklas Beyersdorf, Sofia Dembski
Publikováno v:
Journal of Functional Biomaterials, Vol 13, Iss 3, p 111 (2022)
A fine balance of regulatory (Treg) and conventional CD4+ T cells (Tconv) is required to prevent harmful immune responses, while at the same time ensuring the development of protective immunity against pathogens. As for many cellular processes, sphin
Externí odkaz:
https://doaj.org/article/e2ea70cdd7fe4ca395b1c4625871b283
Autor:
Nina Geiger, Louise Kersting, Jan Schlegel, Linda Stelz, Sofie Fähr, Viktoria Diesendorf, Valeria Roll, Marie Sostmann, Eva-Maria König, Sebastian Reinhard, Daniela Brenner, Sibylle Schneider-Schaulies, Markus Sauer, Jürgen Seibel, Jochen Bodem
Publikováno v:
Cells, Vol 11, Iss 16, p 2532 (2022)
SARS-CoV-2 variants such as the delta or omicron variants, with higher transmission rates, accelerated the global COVID-19 pandemic. Thus, novel therapeutic strategies need to be deployed. The inhibition of acid sphingomyelinase (ASM), interfering wi
Externí odkaz:
https://doaj.org/article/4705392c2f834d74a1d8519e5904d468
Autor:
Marco R. Rink, Marisa A. P. Baptista, Felix J. Flomm, Thomas Hennig, Adam W. Whisnant, Natalia Wolf, Jürgen Seibel, Lars Dölken, Jens B. Bosse
Publikováno v:
PLoS ONE, Vol 16, Iss 8 (2021)
Fluorogenic aptamers are an alternative to established methodology for real-time imaging of RNA transport and dynamics. We developed Broccoli-aptamer concatemers ranging from 4 to 128 substrate-binding site repeats and characterized their behavior fu
Externí odkaz:
https://doaj.org/article/21840b55e9c4416483655d04ba35b5a6