Výsledky vyhledávání - "Jürgen Scherberich"

Akademický článek

Serum uromodulin associates with kidney function and outcome in a cohort of hospitalised COVID-19 patients

Autor: Ralph Wendt, Martin Macholz, Sven Kalbitz, Nadja Herrmann, Victor Herbst, Tabea Hammes, Marco Kai, Hendrik Jan Ankersmit, Joachim Beige, Christoph Lübbert, Alexandra Graf, Jürgen Scherberich

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)

Abstract This study investigates the prevalence and evaluates the prognostic implications of acute kidney injury (AKI) in COVID-19 patients, with a novel emphasis on the evaluation of serum uromodulin (sUmod) as a potential kidney-specific biomarker.

Externí odkaz: https://doaj.org/article/7ce8cb16bdc8436eb4a54e13975f21bb

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Akademický článek

Serum uromodulin is inversely associated with the metabolic syndrome in the KORA F4 study

Autor: Cornelia Then, Holger Then, Andreas Lechner, Cornelia Huth, Christa Meisinger, Margit Heier, Annette Peters, Wolfgang Koenig, Wolfgang Rathmann, Christian Herder, Michael Roden, Jürgen Scherberich, Jochen Seissler

Publikováno v: Endocrine Connections, Vol 8, Iss 10, Pp 1363-1371 (2019)

Objective: Metabolic syndrome and obesity are risk factors for chronic kidney disease. However, early kidney alterations may escape diagnosis in these conditions due to glomerular hyperfiltration. Uromodulin, a glycoprotein exclusively synthesized in

Externí odkaz: https://doaj.org/article/61a55acd317042908a0e4e8b554e1486

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Akademický článek

Extratubular Polymerized Uromodulin Induces Leukocyte Recruitment and Inflammation In Vivo

Autor: Roland Immler, Bärbel Lange-Sperandio, Tobias Steffen, Heike Beck, Ina Rohwedder, Jonas Roth, Matteo Napoli, Georg Hupel, Frederik Pfister, Bastian Popper, Bernd Uhl, Hanna Mannell, Christoph A. Reichel, Volker Vielhauer, Jürgen Scherberich, Markus Sperandio, Monika Pruenster

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Uromodulin (UMOD) is produced and secreted by tubular epithelial cells. Secreted UMOD polymerizes (pUMOD) in the tubular lumen, where it regulates salt transport and protects the kidney from bacteria and stone formation. Under various pathological co

Externí odkaz: https://doaj.org/article/745309dbf1514ede9534274d726a3ede

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Serum Uromodulin in Children and Adolescents with Type 1 Diabetes Mellitus and Controls: Its Potential Role in Kidney Health

Autor: Ralf, Schiel, Mathias, Block, Günter, Stein, Antje, Steveling, Sarah, Lücking, Jürgen, Scherberich

Publikováno v: Experimental and Clinical Endocrinology & Diabetes. 131:142-152

Introduction Uromodulin is a kidney-specific tubular protein, and its assessment in serum (sUMOD) reveals the potential as a novel marker for function and the integrity of renal parenchymal cells and does not directly depend on the glomerular filtrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f874a48f183dfe50732165aa95d0f07
https://doi.org/10.1055/a-1944-2686

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Association of serum uromodulin with adipokines in dependence of type 2 diabetes

Autor: Cornelia Then, Christian Herder, Barbara Thorand, Chaterina Sujana, Margit Heier, Christa Meisinger, Annette Peters, Wolfgang Koenig, Wolfgang Rathmann, Michael Roden, Michael Stumvoll, Haifa Maalmi, Holger Then, Uta Ferrari, Jürgen Scherberich, Jochen Seissler

Publikováno v: Cytokine 150:155786 (2022)

Background: The renal tubular glycoprotein uromodulin is associated with obesity and type 2 diabetes, but the underlying mechanisms are elusive. We investigated the association of serum uromodulin with adipokines and tested the effect modification by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49e16bf99a7a20529b0ab271fed2391
https://pubmed.ncbi.nlm.nih.gov/34920231

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Urinary uromodulin independently predicts end-stage renal disease and rapid kidney function decline in a cohort of chronic kidney disease patients

Autor: Dominik, Steubl, Matthias, Block, Victor, Herbst, Wolfgang Andreas, Nockher, Wolfgang, Schlumberger, Stephan, Kemmner, Quirin, Bachmann, Susanne, Angermann, Ming, Wen, Uwe, Heemann, Lutz, Renders, Pranav S, Garimella, Jürgen, Scherberich

Publikováno v: Medicine

Supplemental Digital Content is available in the text
Data on risk factors predicting rapid progression to end-stage renal disease (ESRD) or short-term kidney function decline (i.e., within 1 year) in chronic kidney disease (CKD) are rare but ur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::41b8d31ff5d5b799c23b7a8a6de44a20
https://pubmed.ncbi.nlm.nih.gov/31124979

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Plasma Uromodulin Correlates With Kidney Function and Identifies Early Stages in Chronic Kidney Disease Patients

Autor: Dominik, Steubl, Matthias, Block, Victor, Herbst, Wolfgang Andreas, Nockher, Wolfgang, Schlumberger, Robin, Satanovskij, Susanne, Angermann, Anna-Lena, Hasenau, Lynne, Stecher, Uwe, Heemann, Lutz, Renders, Jürgen, Scherberich

Publikováno v: Medicine

Uromodulin, released from tubular cells of the ascending limb into the blood, may be associated with kidney function. This work studies the relevance of plasma uromodulin as a biomarker for kidney function in an observational cohort of chronic kidney

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a48c5f365fd7fc4e8e11be11168822d7
https://pubmed.ncbi.nlm.nih.gov/26962815

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