Výsledky vyhledávání - "Jürgen Roos"

Efficient Enzymatic Amine Resolution at High Substrate Input Using Diethyl Malonate as an Acyl Donor of Low Hazard Potential

Autor: Sabine Simon, Harald Gröger, Steffen Dr. Oßwald, Jürgen Roos

Publikováno v: Zeitschrift für Naturforschung B. 67:1123-1126

Diethyl malonate turned out to be both a “green” and highly efficient acyl donor in the lipase-catalyzed resolution of amines, thus representing an attractive alternative to currently applied acyl donors. By means of this acyl donor a highly effi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95fac45e188b4f25564340d1188349d2
https://doi.org/10.5560/znb.2012-0127

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Development of a Commercial Process for (S)-β-Phenylalanine

Autor: Steffen Osswald, Jürgen Roos, J. Ian Grayson

Publikováno v: Organic Process Research & Development. 15:1201-1206

The development of a commercial manufacturing route for (S)-β-phenylalanine 8, a key pharmaceutical building block, is described. The different approaches which were investigated, based on catalytic asymmetric hydrogenation of enamide intermediates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4778d1e9e6208b37ea75c12001304d66
https://doi.org/10.1021/op200084g

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Substrate Specificity of Mutants of the Hydroxynitrile Lyase from Manihot esculenta

Autor: Siegfried Förster, Franz Effenberger, Jürgen Roos, Holger Bühler, Harald Wajant

Publikováno v: ChemBioChem. 4:211-216

Several tryptophan128-substituted mutants of the hydroxynitrile lyase from Manihot esculenta (MeHNL) are constructed and applied in the MeHNL-catalyzed addition of HCN to various aromatic and aliphatic aldehydes as well as to methyl and ethyl ketones

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b5b3a043f6b1d517f3a9cb9911b93f
https://doi.org/10.1002/cbic.200390033

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Stereoselective synthesis of β-amino-γ-butyrolactones

Autor: Jürgen Roos, Franz Effenberger

Publikováno v: Tetrahedron: Asymmetry. 13:1855-1862

A novel synthesis of optically active β-amino-γ-butyrolactones is described. O -Silylated ( R )-cyanohydrins ( R )- 3 (derived from aldehydes 1 by ( R )-hydroxynitrile lyase (( R )-PaHNL)-catalyzed addition of HCN) were reacted with allyl Grignard

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc5f49201cac5b71d23e1593d3485de9
https://doi.org/10.1016/s0957-4166(02)00437-8

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Hydroxynitrile lyase-catalyzed addition of HCN to 4-substituted cyclohexanones: stereoselective preparation of tetronic acids

Autor: Christoph Kobler, Holger Bühler, Franz Effenberger, Jürgen Roos

Publikováno v: Canadian Journal of Chemistry. 80:671-679

The addition of HCN to 4-alkylcyclohexanones 1 to give cyanohydrins 2 is strongly catalyzed by hydroxy-ni trile lyases (HNLs). With PaHNL, from bitter almond, trans-addition occurs almost exclusively, yielding trans-2. With MeHNL, from cassava, cis-a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4bdd603fcaf1315db045f8ad390ef635
https://doi.org/10.1139/v02-087

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Stereoselective synthesis of 3-amino-4,5-dihydroxyaldehydes—a novel preparation of N-acetyl-l-daunosamine

Autor: Franz Effenberger, Jürgen Roos

Publikováno v: Tetrahedron: Asymmetry. 11:1085-1095

A general route for the stereoselective synthesis of 3-amino-4,5-dihydroxyaldehydes, with almost any desired configuration at the three stereogenic centers, is described by applying a combination of enzymatic and chemical steps. l -Daunosamine 1 , fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::923750d9a83292ed473fe57c75a89d4d
https://doi.org/10.1016/s0957-4166(00)00056-2

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Expression of the Zn2+-containing hydroxynitrile lyase from flax (Linum usitatissimum) in Pichia pastoris— utilization of the recombinant enzyme for enzymatic analysis and site-directed mutagenesis

Autor: Siegfried Förster, Jürgen Roos, Klaus Pfizenmaier, Klaus Trummler, Harald Wajant, Ulrich Schwaneberg, Franz Effenberger

Publikováno v: Plant Science. 139:19-27

Hydroxynitrile lyases (HNL) are involved in the catabolism of cyanogenic glycosides in cyanogenic plants and are powerful tools in the stereoselective synthesis of cyanohydrins. The recent cloning of the hydroxynitrile lyase from flax ( Linum usitati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91da8d9522324b871f44cd4410b633b8
https://doi.org/10.1016/s0168-9452(98)00173-3

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Synthesis of (1R,cis,αS)-cypermethrine via lipase catalyzed kinetic resolution of racemic m-phenoxybenzaldehyde cyanohydrin acetate

Autor: Franz Effenberger, Jürgen Roos, Uwe Stelzer

Publikováno v: Tetrahedron: Asymmetry. 9:1043-1049

A technical scale preparation of optically active (1 R , cis ,α S )-cypermethrine 4 from racemic m -phenoxybenzaldehyde cyanohydrin acetate ( RS )- 1 and (1 R , cis )-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid chloride (1 R , cis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e271baf63bae50143b221b3c86c9327b
https://doi.org/10.1016/s0957-4166(98)00047-0

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Enzyme catalyzed addition of hydrocyanic acid to substituted pivalaldehydes — A novel synthesis of (R)-pantolactone

Autor: Franz Effenberger, Jürgen Roos, Joachim Eichhorn

Publikováno v: Tetrahedron: Asymmetry. 6:271-282

(R)-Cyanohydrins (R)- 2b-h are obtained in good optical yields by (R)-oxynitrilase catalyzed enantioselective addition of HCN to β-substituted pivalaldehydes 1b-h. Under optimized reaction conditions with highly purified (R)-oxynitrilase, hydroxypiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d566d08fae1ebafee38ccd2fe9cf84eb
https://doi.org/10.1016/0957-4166(94)00384-n

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