Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jürgen O. Daiss"'
Autor:
David John Miller, John S. Mills, Diana Kuehn, Matthias W. Büttner, Bin Zhu, L. H. Tam, Philip Avlar BioVentures Mitchell, David Tebbe, Christian Burschka, Helen Rapley, Ian C. Gray, Parameswary A. Muniandy, Reinhold Tacke, Matthew J. Barnes, Jürgen O. Daiss, Alan G. Hendrick, Julie B. H. Warneck, Richard Conroy, Graham A. Showell, John Gary Montana
Publikováno v:
ChemMedChem. 6:2070-2080
AG-045572 (CMPD1, 1 a) is a nonpeptidic gonadotropin-releasing hormone (GnRH) antagonist that has been investigated for the treatment of sex hormone-related diseases. In the context of systematic studies on sila-substituted drugs, the silicon analogu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0906f5604ca83099549d80545ab529
https://doi.org/10.1002/cmdc.201100318
https://doi.org/10.1002/cmdc.201100318
Autor:
Reinhold Tacke, Jürgen O. Daiss, Richard Paradigm Therapeutics Ltd. Conroy, Etsuo Kotani, Miller David, Ryo Mizojiri, Louise Marie Walsh, Tetsuji Kawamoto
Publikováno v:
Tetrahedron. 66:7738-7742
1,1,3,3,6-Pentamethyl-1,3-disilaindan-5-ol (2) is a key intermediate in the synthesis of new sila-substituted gonadotropin releasing hormone receptor antagonists, such as 1. In order to produce sufficient quantities of 1 for pharmacological and toxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec5e2ee61b376c9d5e4105924256bdba
https://doi.org/10.1016/j.tet.2010.07.068
https://doi.org/10.1016/j.tet.2010.07.068
Autor:
John A. Rudd, Matt Barnes, Jürgen O. Daiss, John G Montana, Julie Belinda Hazel Warneck, Man-P. Ngan, Man-K. Wai, John S Mills, Reinhold Tacke, Robert J. Naylor, Frankie H.M. Cheng
Publikováno v:
Toxicology and Applied Pharmacology. 232:369-375
The chemotherapeutic drug cisplatin is associated with severe gastrointestinal toxicity that can last for several days. A recent strategy to treat the nausea and emesis includes the combination of a 5-HT3 receptor antagonist, a glucocorticoid, and an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e226d8361e6ee4a277ba9d5e64ec6b1
https://doi.org/10.1016/j.taap.2008.07.003
https://doi.org/10.1016/j.taap.2008.07.003
Autor:
Jennifer B. Nätscher, Friedrich Popp, Jürgen O. Daiss, Reinhold Tacke, and Christian Burschka
Publikováno v:
Organometallics. 26:6014-6028
A series of triorganyl(2,4,6-trimethoxyphenyl)silanes containing various combinations of acid-labile protecting groups for silicon, including allyl, 2,6-dimethoxyphenyl, mesityl, 4-methoxyphenyl, 1-naphthyl, and phenyl, were synthesized and character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a9dc4e2d1ca5cf85626cc6c79d051bd
https://doi.org/10.1021/om700805p
https://doi.org/10.1021/om700805p
Autor:
John S. Mills, Jürgen O. Daiß, John Gary Montana, Reinhold Tacke, Graham A. Showell, Julie B. H. Warneck, Christian Burschka
Publikováno v:
Journal of Organometallic Chemistry. 691:3589-3595
rac-Desmethoxy-sila-venlafaxine (rac-3) is a derivative of the noradrenaline-selective serotonin/noradrenaline reuptake inhibitor rac-sila-venlafaxine (rac-1b), a silicon analogue of the serotonin-selective serotonin/noradrenaline reuptake inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddcbaa4d70d57eb1708f94ae24a41187
https://doi.org/10.1016/j.jorganchem.2006.04.015
https://doi.org/10.1016/j.jorganchem.2006.04.015
Autor:
Ian N. Fleming, Graham Andrew Showell, Claudine Gaudon, Christian Burschka, Jürgen O. Daiss, Diana Ivanova, Hinrich Gronemeyer, John S. Mills, Reinhold Tacke, John Gary Montana
Publikováno v:
Organometallics. 24:3192-3199
Twofold sila-substitution (C/Si exchange) in the saturated ring of the tetrahydronaphthalene skeleton of the RXR-selective retinoid agonist bexarotene (1a) leads to disila-bexarotene (1b). Compound 1b was synthesized in a multistep synthesis, startin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f3efe4b00ed5c32caed44fc0e147191
https://doi.org/10.1021/om040143k
https://doi.org/10.1021/om040143k
Publikováno v:
Journal of Organometallic Chemistry. 690:678-684
A series of novel β-carbonylsilanes, with a silacyclohexane skeleton and additional C-functionalized organyl groups at the silicon atom, were synthesized, their reactivity was explored, and they were structurally characterized by multinuclear NMR sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96d4156f633196e9e5d663f7aca5f16b
https://doi.org/10.1016/j.jorganchem.2004.08.048
https://doi.org/10.1016/j.jorganchem.2004.08.048
Publikováno v:
Organometallics. 23:6052-6057
N,N,N‘,N‘-Tetramethyl-N,N‘-bis(3-phthalimidopropyl)hexane-1,6-diaminium bromide (W84, 1) is an allosteric agent for the “common allosteric site” of muscarinic M2 receptors that slows the dissociation of the orthosteric ligand [3H]N-methylsc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bb7e344d515dfd15f591224d34a36ba
https://doi.org/10.1021/om040088f
https://doi.org/10.1021/om040088f
Publikováno v:
Organometallics. 23:4987-4994
The Si-2,4,6-trimethoxyphenyl (Si-2,4,6-TMOP) moiety is claimed to be an effective protecting group for synthetic organosilicon chemistry. To demonstrate its high synthetic potential, the Si-2,4,6-TMOP protecting group has been used for a novel multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3884644140b5e22f9ff7a0074639efd5
https://doi.org/10.1021/om040087n
https://doi.org/10.1021/om040087n
Publikováno v:
Journal of Organometallic Chemistry. 686:75-83
The silicon-based allosteric modulators of ligand binding to muscarinic acetylcholine receptors [R1(CH2)3SiMe2(CH2)5NMe2(CH2)3R1]Br (3), [R2(CH2)3SiMe2(CH2)5NMe2(CH2)3R2]Br (4), [R1(CH2)3SiMe2(CH2)5NMe2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f50e1e3498d60addd991c5ee113bd0a
https://doi.org/10.1016/s0022-328x(03)00553-9
https://doi.org/10.1016/s0022-328x(03)00553-9