Výsledky vyhledávání - "Jürgen Leser"

Correction: Cyclic AMP induces transactivation of the receptors for epidermal growth factor and nerve growth factor, thereby modulating activation of MAP kinase, Akt, and neurite outgrowth in PC12 cells

Autor: Albrecht Piiper, Ivan Dikic, Manfred P. Lutz, Jürgen Leser, Bernd Kronenberger, Robert Elez, Henning Cramer, Werner Müller-Esterl, Stefan Zeuzem

Publikováno v: The Journal of biological chemistry. 295(43)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c83a0ea82b04763a429ade2c31d3c630
https://pubmed.ncbi.nlm.nih.gov/12218049

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Caspase 8-mediated cleavage of plectin precedes F-actin breakdown in acinar cells during pancreatitis

Autor: Anna S. Gukovskaya, Grit Lynch, Jürgen Leser, Michael Beil, Thomas Seufferlein, Manfred P. Lutz, Stephen J. Pandol, Guido Adler

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 282:G450-G460

Pancreatic acinar cells depend on the integrity of the cytoskeleton for regulated secretion. Stimulation of isolated rat pancreatic acini with the secretagogue CCK serves as a model for human acute edematous pancreatitis. It induces the breakdown of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52957152f7b448eee8fbefd761034f47
https://doi.org/10.1152/ajpgi.00042.2001

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Cholecystokinin-Induced Redistribution of Paxillin in Rat Pancreatic Acinar Cells

Autor: Guido Adler, Manfred P. Lutz, Hardi Lührs, Jürgen Leser, Michael Beil

Publikováno v: Biochemical and Biophysical Research Communications. 254:400-405

Cholecystokinin (CCK) dose-dependently stimulates enzyme secretion or loss of cell integrity in the exocrine pancreas. Signaling mechanims include tyrosine phosphorylation of p125 FAK and paxillin. Here, we examine their potential function. Maximum p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5de81a9fddd6be50abd27d3fb0f0f0
https://doi.org/10.1006/bbrc.1998.9413

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Dissociation and reassembly of adherens junctions during experimental acute pancreatitis

Autor: Jürgen Leser, Manfred P. Lutz, Markus M. Lerch, Hans Weidenbach, F. Müller-Pillasch, Thomas M. Gress, Gail K. Adler

Publikováno v: Europe PubMed Central

BACKGROUND & AIMS: The initial pathophysiological events that characterize acute pancreatitis include the formation of pancreatic edema. An interstitial accumulation of fluid, however, is incompatible with the presence of intact intercellular junctio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ddcdc1dfbbb32ad6bce16c459e020a
https://doi.org/10.1053/gast.1997.v113.pm9322531

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Cyclic AMP induces transactivation of the receptors for epidermal growth factor and nerve growth factor, thereby modulating activation of MAP kinase, Akt, and neurite outgrowth in PC12 cells

Autor: Stefan Zeuzem, Werner Müller-Esterl, Jürgen Leser, Albrecht Piiper, Bernd Kronenberger, Robert Elez, Henning Cramer, Ivan Dikic, Manfred P. Lutz

Publikováno v: J Biol Chem

In PC12 cells, a well studied model for neuronal differentiation, an elevation in the intracellular cAMP level increases cell survival, stimulates neurite outgrowth, and causes activation of extracellular signal-regulated protein kinase 1 and 2 (ERK1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7094d380bc6dbca7d4b1d7b82f2391
https://pubmed.ncbi.nlm.nih.gov/33097650

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Subcellular distribution and function of Rab3A-D in pancreatic acinar AR42J cells

Autor: Albrecht Piiper, Jürgen Leser, Manfred P. Lutz, Michael Beil, Stefan Zeuzem

Publikováno v: Biochemical and biophysical research communications. 287(3)

Members of the Rab3 subfamily have been linked to the regulation of exocytosis in secretory cells. We have recently shown by Northern blot analysis that pancreatic acinar-like AR42J cells express all four Rab3 isoforms (Rab3A-D). In the present study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5d4002058ce5bfa6d53cae7fd17843
https://pubmed.ncbi.nlm.nih.gov/11563859

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4-Hydroxy-2-pyrone formation by chalcone and stilbene synthase with nonphysiological substrates

Autor: Jürgen Leser, Gudrun Schröder, Joachim Schröder, Robert Verpoorte, Thorsten Berger, Karin W.M. Zuurbier, Albertus J.P Hofte

Publikováno v: Phytochemistry. 49(7)

Valerophenone synthase (VPS) is a polyketide synthase that catalyzes the formation of the phloroglucinol derivatives in the synthesis of the bitter acids in hop (Humulus lupulus). The reaction uses isovaleryl-CoA or isobutyryl-CoA, but otherwise it i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21165b9e3feb1441928b41f063948904
https://pubmed.ncbi.nlm.nih.gov/9883590

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Cadherin/catenin complexes do not mediate the CCK-induced actin filament breakdown in rat pancreatic acini

Autor: Omran A.H. Musa, Gail K. Adler, Jürgen Leser, Manfred P. Lutz

Publikováno v: Gastroenterology. 114:A477

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95d27699f6744bed78dacf0bf6d1639f
https://doi.org/10.1016/s0016-5085(98)81933-1

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Regulation of adherens junction protein p120(ctn) by 10 nM CCK precedes actin breakdown in rat pancreatic acini

Autor: Omran A.H. Musa, Gail K. Adler, Michael Beil, Jürgen Leser, Manfred P. Lutz

Publikováno v: Europe PubMed Central

The initial pathophysiological events that characterize CCK-hyperstimulation pancreatitis include the breakdown of the actin filament system and disruption of cadherin-catenin protein complexes. Cadherins and catenins are part of adherens junctions,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af132bfbc10e80dd8887cb7af01cafe
http://europepmc.org/abstract/med/10712269

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