Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis

Autor: Stefan Steidl, Stéphanie Lavazais, Maté Ongenaert, Maarten Van Balen, Catherine Jagerschmidt, Kilian Eyerich, M. Auberval, Nick Vandeghinste, Jan D. Haas, L. Lepescheux, F. Marsais, Reginald Brys, Teresa Garcia, Jürgen Klattig, Stefan Härtle, Sonia Dupont, F. Lauffer, Padraic G. Fallon, Tara Moran

Publikováno v: Journal of Investigative Dermatology

IL-17C is a functionally distinct member of the IL-17 family that was believed to play a role in the pathogenesis of psoriasis. Here we confirmed that IL-17C is involved in psoriasis and explored potential roles for IL-17C in atopic dermatitis (AD).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ccf4284964d33d9eab7523236662f7
https://pubmed.ncbi.nlm.nih.gov/29941097

WT1-Mediated Gene Regulation in Early Urogenital Ridge Development

Autor: Dagmar Kruspe, Ralph Sierig, M S Makki, Jürgen Klattig, Christoph Englert

Publikováno v: Sexual Development. 1:238-254

The Wilms tumor protein WT1 is involved in the development of several organs, including the gonads. WT1 mutations in humans lead to syndromes associated with impaired sexual development and Wt1 knockout mice show regression of gonad anlagen. As a tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924e83cbfbf79b8785a8c659447f9b0a
https://doi.org/10.1159/000104774

Teratogen-Induced, Dietary and Genetic Models of Congenital Diaphragmatic Hernia Share a Common Mechanism of Pathogenesis

Autor: John J. Greer, Robin D. Clugston, Alexandra Benachi, Margaret Clagett-Dame, Chistoph Englert, Jelena Martinovic, Jürgen Klattig

Publikováno v: The American Journal of Pathology. 169:1541-1549

Congenital diaphragmatic hernia (CDH) is a frequently occurring, major congenital abnormality that has high mortality and significant morbidity in survivors. Currently, the pathogenesis of CDH is poorly understood. In this study, we have compared the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230ea9077427b31bf640f1a75a36e9cb
https://doi.org/10.2353/ajpath.2006.060445

Homozygous Inactivation of Sox9 Causes Complete XY Sex Reversal in Mice1

Autor: Francisco J. Barrionuevo, Christoph Englert, Makoto Mark Taketo, Gerd Scherer, Stefan Bagheri-Fam, Ralf Kist, Jürgen Klattig

Publikováno v: Biology of Reproduction. 74:195-201

In the presence of the Y-chromosomal gene Sry, the bipotential mouse gonads develop as testes rather than as ovaries. The autosomal gene Sox9, a likely and possibly direct Sry target, can induce testis development in the absence of Sry. Sox9 is thus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3170bdba0c43ea7ab992fc8b47b89621
https://doi.org/10.1095/biolreprod.105.045930

The PGD2 pathway, independently of FGF9, amplifies SOX9activity in Sertoli cells during male sexual differentiation

Autor: Laetitia Marzi, Brigitte Moniot, Anne Cohen-Solal, Brigitte Boizet-Bonhoure, Blanche Capel, Faustine Declosmenil, Francis Poulat, Ina Georg, Kosuke Aritake, Francisco J. Barrionuevo, Naomi Eguchi, Jürgen Klattig, Gerd Scherer, Yuna Kim, Safia Malki, Christoph Englert, Yoshihiro Urade

Publikováno v: Development (Cambridge, England)
Development (Cambridge, England), Company of Biologists, 2009, 136 (11), pp.1813-1821. ⟨10.1242/dev.032631⟩

International audience; Activation by the Y-encoded testis determining factor SRY and maintenance of expression of the Sox9 gene encoding the central transcription factor of Sertoli cell differentiation are key events in the mammalian sexual differen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ec904b18e5f5bfc860d05d0b1dc46f
https://hal.archives-ouvertes.fr/hal-00399074