Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jürgen Hemberger"'
Publikováno v:
Drug Discovery Today. 28:103495
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c7d418773865c7d49bc2356f0a37ed1
https://doi.org/10.1016/j.drudis.2023.103495
https://doi.org/10.1016/j.drudis.2023.103495
Proteomics of Galápagos Marine Iguanas Links Function of Femoral Gland Proteins to the Immune System
Autor:
Franziska Lang, Franz Cemic, Marcus Krüger, Alejandro Ibáñez, Lena Abraham, Mario Looso, Galo Quezada, Jürgen Hemberger, Frederik Tellkamp, Daniela Müller, Sebastian Steinfartz, Fabian Jannik Tann, Stefan Günther
Publikováno v:
Molecular & Cellular Proteomics : MCP
Femoral glands secrete a wax-like substance on the inner side of lizard hind legs, which is thought to function as a mode of chemical communication. Though the minor volatile fraction is well studied, the major protein fraction remains enigmatic. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0477147f4c2f5f0146330c4b05e99294
https://doi.org/10.1074/mcp.ra120.001947
https://doi.org/10.1074/mcp.ra120.001947
Autor:
David Brühlmann, Jürgen Hemberger, Zeynep Manco, Alessandra D'Angelo, Eugenio Galano, Jonathan Souquet, Thomas Vuillemin, Abhijeet Satwekar, Markus Sauer, Angelo Palmese, Martin Jordan, Hervé Broly
Publikováno v:
Biotechnology and Bioengineering. 116:1017-1028
Glycosylation, a critical product quality attribute, may affect the efficacy and safety of therapeutic proteins in vivo. Chinese hamster ovary fed-batch cell culture batches yielded consistent glycoprofiles of a Fc-fusion antibody comprizing three di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acce949db3e51d8af6de126a0d3e8e20
https://doi.org/10.1002/bit.26930
https://doi.org/10.1002/bit.26930
Autor:
Michael Sokolov, Markus Sauer, Jonathan Souquet, Alessandro Butté, Martin Jordan, David Brühlmann, Jürgen Hemberger, Hervé Broly
Publikováno v:
Biotechnology and Bioengineering. 114:1448-1458
Rational and high-throughput optimization of mammalian cell culture media has a great potential to modulate recombinant protein product quality. We present a process design method based on parallel design-of-experiment (DoE) of CHO fed-batch cultures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4613a47e9e876767acc8f3400b0d12e7
https://doi.org/10.1002/bit.26269
https://doi.org/10.1002/bit.26269
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 145
Hydrogels from Halomonas levan polysaccharide were prepared at different crosslinking densities. Swelling results demonstrated pH dependent rather than temperature dependent swelling of the hydrogel and the highest swelling value was achieved at basi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7797407852c42b81d47842a6a487ad89
https://pubmed.ncbi.nlm.nih.gov/32032777
https://pubmed.ncbi.nlm.nih.gov/32032777
Autor:
Markus Sauer, Martin Jordan, Hervé Broly, Jürgen Hemberger, David Brühlmann, Matthieu Stettler
Publikováno v:
Biotechnology Progress. 31:615-629
Clinical efficacy and safety of recombinant proteins are closely associated with their structural characteristics. The major quality attributes comprise glycosylation, charge variants (oxidation, deamidation, and C- & N-terminal modifications), aggre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d98c30389586483cff1ac554309fa01c
https://doi.org/10.1002/btpr.2089
https://doi.org/10.1002/btpr.2089
Autor:
Rebecca Parker, David Brühlmann, Jonathan Souquet, Tobias Haas, Thomas Vuillemin, Anaïs Muhr, Martin Jordan, Hervé Broly, Serena Torre, Markus Sauer, Fabio La Neve, Blanka Bucsella, Antonio Lembo, Franka Kalman, Jürgen Hemberger
Publikováno v:
Journal of biotechnology. 252
Glycosylation plays a pivotal role in pharmacokinetics and protein physiochemical characteristics. In particular, effector functions including antibody-dependent cell-mediated cytotoxicity (ADCC) can be desired, and it has been described that high-ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f30bfa2c2536997f1f4f66a9e39c1ed
https://pubmed.ncbi.nlm.nih.gov/28465212
https://pubmed.ncbi.nlm.nih.gov/28465212
Autor:
David, Brühlmann, Michael, Sokolov, Alessandro, Butté, Markus, Sauer, Jürgen, Hemberger, Jonathan, Souquet, Hervé, Broly, Martin, Jordan
Publikováno v:
Biotechnology and bioengineering. 114(7)
Rational and high-throughput optimization of mammalian cell culture media has a great potential to modulate recombinant protein product quality. We present a process design method based on parallel design-of-experiment (DoE) of CHO fed-batch cultures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4189b2eadb0e09d637be6db8e39ba1d7
https://pubmed.ncbi.nlm.nih.gov/28197999
https://pubmed.ncbi.nlm.nih.gov/28197999
Autor:
Franz Cemic, Mobarak Abu Mraheil, Daniela Müller, Trinad Chakraborty, Jürgen Hemberger, Andreas Vilcinskas, Krishnendu Mukherjee, Silke Silva, Torsten Hain
Publikováno v:
Applied and Environmental Microbiology. 77:4237-4240
We report the use of antimicrobial hemolymph proteins from the model host Galleria mellonella as an inhibitor for various Listeria strains, providing a novel source for antilisterial therapeutics. We also have shown that specific virulence-associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adae191a8906dd95dbca2c8f8007e8da
https://doi.org/10.1128/aem.02435-10
https://doi.org/10.1128/aem.02435-10
Autor:
Mobarak Abu Mraheil, Sonja Vorwerk, Jean-Christophe Giard, Bernd Kreikemeyer, Trinad Chakraborty, Anette Jacob, Jürgen Hemberger, Axel Hartke, Susanne Engelmann, Franz Cemic, Markus Beier, André Billion, Maja Rupnik, Jordan Pischimarov, Carsten Kuenne, Julia Retey, Thomas Hartsch, Torsten Hain
Publikováno v:
Microbial Biotechnology. 3:658-676
In the recent years, the number of drug- and multi-drug-resistant microbial strains has increased rapidly. Therefore, the need to identify innovative approaches for development of novel anti-infectives and new therapeutic targets is of high priority
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7c0324c018081a617f2b53c82c7b671
https://doi.org/10.1111/j.1751-7915.2010.00171.x
https://doi.org/10.1111/j.1751-7915.2010.00171.x