Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jürgen Groet"'
Autor:
Hany Ariffin, Shirley Kow-Yin Kham, Jürgen Groet, Wee Joo Chng, David Koschut, Zhenhua Li, Emanuela Giarin, Ivan Alić, Debleena Ray, David M. Weinstock, Dean Nižetić, Giuseppe Basso, Allen Eng Juh Yeoh
Publikováno v:
Oncogene
Leukemias are routinely sub-typed for risk/outcome prediction and therapy choice using acquired mutations and chromosomal rearrangements. Down syndrome acute lymphoblastic leukemia (DS‐ALL) is characterized by high frequency of CRLF2‐rearrangemen
Autor:
Jia Nee Foo, Andre Strydom, Xiaowei Shao, David Koschut, Goran Šimić, Željka Krsnik, Sarah Hamburg, Ivan Alić, Steven Havlicek, Hlin Kvartsberg, Jürgen Groet, Paul T. Francis, Yee Jie Yeap, Pollyanna Goh, Hilkka Soininen, Rosalyn Hithersay, John Hardy, Niamh L. O'Brien, Margaret Phillips, David Laurence Becker, N. Ray Dunn, Gunnar Brinkmalm, David Wallon, Gillian Gough, Henrik Zetterberg, Erik Portelius, Mark Turmaine, Aoife Murray, Jorge Ghiso, Kaj Blennow, Eleni Gkanatsiou, Agueda Rostagno, Carla M. Startin, Ivica Kostović, Konstantin Pervushin, Emanuela V. Volpi, Dean Nižetić, Joanne E. Martin, Dinko Mitrečić, Reinhard Brunmeir, Kin Y. Mok, Anne Rovelet-Lecrux
Publikováno v:
Molecular Psychiatry
A population of more than six million people worldwide at high risk of Alzheimer’s disease (AD) are those with Down Syndrome (DS, caused by trisomy 21 (T21)), 70% of whom develop dementia during lifetime, caused by an extra copy of β-amyloid-(Aβ)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09de58af74b7f90b471059b4fee6daab
https://doi.org/10.1038/s41380-020-0806-5
https://doi.org/10.1038/s41380-020-0806-5
Autor:
Jürgen Groet, Hany Ariffin, Shirley Kow-Yin Kham, Wee Joo Chng, Zhenhua Li, David Koschut, Allen Eng Juh Yeoh, Emanuela Giarin, Debleena Ray, David M. Weinstock, Giuseppe Basso, Dean Nižetić, Ivan Alić
BackgroundDown syndrome acute lymphoblastic leukemia (DS-ALL) is characterized by the high frequency of CRLF2-rearrangements, JAK2-mutations, or RAS-pathway mutations. Intriguingly, JAK2 and RAS mutations are mutually exclusive in leukemic sub-clones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34338f0d08365249bfbaede364e2b9c
https://doi.org/10.1101/2020.02.03.931725
https://doi.org/10.1101/2020.02.03.931725
Autor:
Jorge Ghiso, Agueda Rostagno, Steven Havlicek, Sarah Hamburg, Ivan Alić, Carla M. Startin, Rosalyn Hithersay, Eleni Gkanatsiou, David Koschut, Hlin Kvartsberg, Hilkka Soininen, Emanuela V. Volpi, Xiaowei Shao, Goran Šimić, Željka Krsnik, Dean Nižetić, Mark Turmaine, Joanne E. Martin, Jürgen Groet, Aoife Murray, Erik Portelius, Pollyanna Goh, Jia Nee Foo, Niamh L. O'Brien, Henrik Zetterberg, Andre Strydom, Yee Jie Yeap, David Wallon, Gillian Gough, John Hardy, Margaret Phillips, N. Ray Dunn, Dinko Mitrečić, Gunnar Brinkmalm, Reinhard Brunmeir, Kin Y. Mok, Anne Rovelet-Lecrux, Kaj Blennow, Ivica Kostović, Konstantin Pervushin, Paul T. Francis, David Laurence Becker
A population of >6 million people worldwide at high risk of Alzheimer’s disease (AD) are those with Down Syndrome (DS, caused by trisomy 21 (T21)), 70% of whom develop dementia during lifetime, caused by an extra copy of β-amyloid-(Aβ)-precursor-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::111391dc58615029c3c88bcbe66e06ec
Autor:
Niamh L. O'Brien, Jürgen Groet, Pollyanna Goh, Gillian Gough, Aoife Murray, Ivan Alić, Yee Jie Yeap, Dean Nizetic
Down Syndrome (DS) is a complex chromosomal disorder, with neurological issues, featuring among the symptoms. Primary neuronal cells and tissues are extremely useful, but limited both in supply and experimental manipulability. To better understand th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c14b1690104b1e7420aceec76fc22e66
https://doi.org/10.1016/bs.pbr.2019.10.003
https://doi.org/10.1016/bs.pbr.2019.10.003
Autor:
Aoife Murray, Gillian Gough, Ana Cindrić, Frano Vučković, David Koschut, Vincenzo Borelli, Dražen J. Petrović, Ana Bekavac, Ante Plećaš, Valentina Hribljan, Reinhard Brunmeir, Julija Jurić, Maja Pučić-Baković, Anita Slana, Helena Deriš, Azra Frkatović, Jűrgen Groet, Niamh L. O’Brien, Hong Yu Chen, Yee Jie Yeap, Frederic Delom, Steven Havlicek, Luke Gammon, Sarah Hamburg, Carla Startin, Hana D’Souza, Dinko Mitrečić, Mijana Kero, Ljubica Odak, Božo Krušlin, Željka Krsnik, Ivica Kostović, Jia Nee Foo, Yuin-Han Loh, Norris Ray Dunn, Susana de la Luna, Tim Spector, Ingeborg Barišić, Michael S.C. Thomas, Andre Strydom, Claudio Franceschi, Gordan Lauc, Jasminka Krištić, Ivan Alić, Dean Nižetić
Publikováno v:
EBioMedicine, Vol 94, Iss , Pp 104692- (2023)
Summary: Background: People with Down syndrome (DS) show clinical signs of accelerated ageing. Causative mechanisms remain unknown and hypotheses range from the (essentially untreatable) amplified-chromosomal-instability explanation, to potential act
Externí odkaz:
https://doaj.org/article/fccbd6f8ccf04865a74224623e30be79
Autor:
Elizabeth M. C. Fisher, Rosalyn Hithersay, Andre Strydom, David Wallon, Jürgen Groet, Frances K. Wiseman, Sarah Hamburg, Hana D'Souza, Yee-Jie Yeap, Annette Karmiloff-Smith, Pollyanna Goh, Kin Y. Mok, John Hardy, Aoife Murray, Anne Rovelet-Lecrux, Alexandra Botté, Carla M. Startin, Dean Nizetic, Victor L. J. Tybulewicz, Jerry Chan, Marie-Claude Potier, George Augustine, Mahesh Choolani
Publikováno v:
Alzheimer's & Dementia. 13
Autor:
Dean Nizetic, Carla M. Startin, Annette Karmiloff-Smith, Kin Y. Mok, Elizabeth M. C. Fisher, Andre Strydom, Hana D'Souza, Victor L. J. Tybulewicz, Tamara Al-Janabi, John Hardy, Jürgen Groet, Esha Massand
Publikováno v:
Karmiloff-Smith, A, Al-Janabi, T, D'Souza, H, Groet, J, Massand, E, Mok, K, Startin, C, Fisher, E, Hardy, J, Nizetic, D, Tybulewicz, V & Strydom, A 2016, ' The importance of understanding individual differences in Down syndrome ', F1000Research, vol. 5 . https://doi.org/10.12688/f1000research.7506.1
F1000Research
F1000Research
In this article, we first present a summary of the general assumptions about Down syndrome (DS) still to be found in the literature. We go on to show how new research has modified these assumptions, pointing to a wide range of individual differences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e85176f99e0cb354a6b24f27eea0c30
http://hdl.handle.net/10044/1/32745
http://hdl.handle.net/10044/1/32745
Autor:
Jürgen Groet, Elizabeth M. C. Fisher, John Hardy, Dean Nizetic, Andre Strydom, Lewis F Buss, Laura J. Pulford
Publikováno v:
F1000Research
Down syndrome (DS), which arises from trisomy of chromosome 21, is associated with deposition of large amounts of amyloid within the central nervous system. Amyloid accumulates in two compartments: as plaques within the brain parenchyma and in vessel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee5a14d1a598d0142aa5bc183c63a236
https://hdl.handle.net/10356/89657
https://hdl.handle.net/10356/89657
Autor:
Dean Nižetić, Jürgen Groet
Publikováno v:
Nature Reviews Cancer. 12:721-732
If assessed by a number of criteria for cancer predisposition, Down's syndrome (DS) should be an overwhelmingly cancer-prone condition. Although childhood leukaemias occur more frequently in DS, paradoxically, individuals with DS have a markedly lowe