Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Jürgen G, Okun"'
Autor:
Yuqin Wu, Ashish Foollee, Andrea Y. Chan, Susanne Hille, Jana Hauke, Matthew P. Challis, Jared L. Johnson, Tomer M. Yaron, Victoria Mynard, Okka H. Aung, Maria Almira S. Cleofe, Cheng Huang, Terry C. C. Lim Kam Sian, Mohammad Rahbari, Suchira Gallage, Mathias Heikenwalder, Lewis C. Cantley, Ralf B. Schittenhelm, Luke E. Formosa, Greg C. Smith, Jürgen G. Okun, Oliver J. Müller, Patricia M. Rusu, Adam J. Rose
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The peptide hormone glucagon is a fundamental metabolic regulator that is also being considered as a pharmacotherapeutic option for obesity and type 2 diabetes. Despite this, we know very little regarding how glucagon exerts its pleiotropic
Externí odkaz:
https://doaj.org/article/2996febe0d924ecca6c4254d1c0d96ef
Autor:
Salmina J. Guivala, Konrad A. Bode, Jürgen G. Okun, Ece Kartal, Edzard Schwedhelm, Luca V. Pohl, Sarah Werner, Sandra Erbs, Holger Thiele, Petra Büttner
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-16 (2024)
Abstract Background Heart failure with preserved ejection fraction (HFpEF) is associated with systemic inflammation, obesity, metabolic syndrome, and gut microbiome changes. Increased trimethylamine-N-oxide (TMAO) levels are predictive for mortality
Externí odkaz:
https://doaj.org/article/df99ae5302aa403c95b962f052eac7cd
Autor:
Yuqin Wu, Andrea Y. Chan, Jana Hauke, Okka Htin Aung, Ashish Foollee, Maria Almira S. Cleofe, Helen Stölting, Mei-Ling Han, Katherine J. Jeppe, Christopher K. Barlow, Jürgen G. Okun, Patricia M. Rusu, Adam J. Rose
Publikováno v:
Molecular Metabolism, Vol 90, Iss , Pp 102064- (2024)
Objective: The study aimed to investigate the effects of glucagon on metabolic pathways in mouse models of obesity, fatty liver disease, and type 2 diabetes (T2D) to determine the extent and variability of hepatic glucagon resistance in these conditi
Externí odkaz:
https://doaj.org/article/7b5d434a1f864e27ad18d8b1df2a4fc1
Autor:
Elena Schnabel-Besson, Ulrike Mütze, Nicola Dikow, Friederike Hörster, Marina A. Morath, Karla Alex, Heiko Brennenstuhl, Sascha Settegast, Jürgen G. Okun, Christian P. Schaaf, Eva C. Winkler, Stefan Kölker
Publikováno v:
International Journal of Neonatal Screening, Vol 10, Iss 3, p 62 (2024)
Driven by technological innovations, newborn screening (NBS) panels have been expanded and the development of genomic NBS pilot programs is rapidly progressing. Decisions on disease selection for NBS are still based on the Wilson and Jungner (WJ) cri
Externí odkaz:
https://doaj.org/article/2052af20549a4a61975bc6f6d9e871cc
Autor:
Svenja Scharre, Roland Posset, Sven F. Garbade, Florian Gleich, Marie J. Seidl, Ann‐Catrin Druck, Jürgen G. Okun, Andrea L. Gropman, Sandesh C. S. Nagamani, Georg F. Hoffmann, Stefan Kölker, Matthias Zielonka, for the Urea Cycle Disorders Consortium (UCDC) and the European registry and network for Intoxication type Metabolic Diseases (E‐IMD) Consortia Study Group
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 11, Pp 1715-1726 (2022)
Abstract Objective Ornithine transcarbamylase deficiency (OTC‐D) is an X‐linked metabolic disease and the most common urea cycle disorder. Due to high phenotypic heterogeneity, ranging from lethal neonatal hyperammonemic events to moderate sympto
Externí odkaz:
https://doaj.org/article/80a717ca16474543b1d406f7323ea749
Autor:
Gwendolyn Gramer, Saskia B. Wortmann, Junmin Fang-Hoffmann, Dirk Kohlmüller, Jürgen G. Okun, Holger Prokisch, Thomas Meitinger, Georg F. Hoffmann
Publikováno v:
International Journal of Neonatal Screening, Vol 10, Iss 1, p 17 (2024)
Newborn screening (NBS) for hepatorenal tyrosinemia type I (HT1) based on a determination of succinylacetone is performed in countries worldwide. Recently, biallelic pathogenic variants in GSTZ1 underlying maleylacetoacetate isomerase (MAAI) deficien
Externí odkaz:
https://doaj.org/article/3fbaeff2f15a418bae817fb842064df4
Autor:
Pia Maier, Sumathy Jeyaweerasinkam, Janina Eberhard, Lina Soueidan, Susanne Hämmerling, Dirk Kohlmüller, Patrik Feyh, Gwendolyn Gramer, Sven F. Garbade, Georg F. Hoffmann, Jürgen G. Okun, Olaf Sommerburg
Publikováno v:
International Journal of Neonatal Screening, Vol 10, Iss 1, p 5 (2024)
Newborn screening (NBS) for cystic fibrosis (CF) based on pancreatitis-associated protein (PAP) has been performed for several years. While some influencing factors are known, there is currently a lack of information on the influence of seasonal temp
Externí odkaz:
https://doaj.org/article/e0c6ae699db647dfb9155aa3279b50db
Autor:
Maximiliano L. Cacicedo, Christine Weinl-Tenbruck, Daniel Frank, Sebastian Wirsching, Beate K. Straub, Jana Hauke, Jürgen G. Okun, Nigel Horscroft, Julia B. Hennermann, Fred Zepp, Frédéric Chevessier-Tünnesen, Stephan Gehring
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 294-308 (2022)
Hereditary tyrosinemia type 1 is an inborn error of amino acid metabolism characterized by deficiency of fumarylacetoacetate hydrolase (FAH). Only limited treatment options (e.g., oral nitisinone) are available. Patients must adhere to a strict diet
Externí odkaz:
https://doaj.org/article/c558916830de456c8e082c476d56542c
Autor:
Solomon A. Sowah, Alessio Milanese, Ruth Schübel, Jakob Wirbel, Ece Kartal, Theron S. Johnson, Frank Hirche, Mirja Grafetstätter, Tobias Nonnenmacher, Romy Kirsten, Marina López-Nogueroles, Agustín Lahoz, Kathrin V. Schwarz, Jürgen G. Okun, Cornelia M. Ulrich, Johanna Nattenmüller, Arnold von Eckardstein, Daniel Müller, Gabriele I. Stangl, Rudolf Kaaks, Tilman Kühn, Georg Zeller
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-21 (2022)
Abstract Background The gut microbiota has been suggested to play a significant role in the development of overweight and obesity. However, the effects of calorie restriction on gut microbiota of overweight and obese adults, especially over longer du
Externí odkaz:
https://doaj.org/article/b2a9d6f5ed5d4fb9a3a65f3eb76bef31
Autor:
Lucia Laugwitz, Laimdota Zizmare, Vidiyaah Santhanakumaran, Claire Cannet, Judith Böhringer, Jürgen G. Okun, Manfred Spraul, Ingeborg Krägeloh‐Mann, Samuel Groeschel, Christoph Trautwein
Publikováno v:
JIMD Reports, Vol 63, Iss 2, Pp 168-180 (2022)
Abstract Metachromatic leukodystrophy (MLD) is a lysosomal storage disease caused by a deficiency of the arylsulfatase A (ARSA). ARSA deficiency leads to an accumulation of sulfatides primarily in the nervous system ultimately causing demyelination.
Externí odkaz:
https://doaj.org/article/0f1efdd0ccc549398ca53844ee8f0043