Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Jürgen Fingerle"'
Autor:
Uwe Grether, Richard H. Foxton, Sabine Gruener, Claudia Korn, Atsushi Kimbara, Anja Osterwald, Elisabeth Zirwes, Sabine Uhles, Janina Thoele, Nadine Colé, Mark Rogers-Evans, Stephan Röver, Matthias Nettekoven, Rainer E. Martin, Jean-Michel Adam, Jürgen Fingerle, Caterina Bissantz, Wolfgang Guba, André Alker, Anna M. Szczesniak, Ross F. Porter, Tom J. Toguri, Franco Revelant, Agnès Poirier, Camille Perret, Lotte Winther, Antonello Caruso, Filomena Fezza, Mauro Maccarrone, Melanie E. M. Kelly, Sascha Fauser, Christoph Ullmer
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionPreclinical studies suggest that cannabinoid receptor type 2 (CB2R) activation has a therapeutic effect in animal models on chronic inflammation and vascular permeability, which are key pathological features of diabetic retinopathy (DR).
Externí odkaz:
https://doaj.org/article/91d1c3e1c6e44284b2f5d719fd280ff1
Autor:
Marjolein Soethoudt, Uwe Grether, Jürgen Fingerle, Travis W. Grim, Filomena Fezza, Luciano de Petrocellis, Christoph Ullmer, Benno Rothenhäusler, Camille Perret, Noortje van Gils, David Finlay, Christa MacDonald, Andrea Chicca, Marianela Dalghi Gens, Jordyn Stuart, Henk de Vries, Nicolina Mastrangelo, Lizi Xia, Georgios Alachouzos, Marc P. Baggelaar, Andrea Martella, Elliot D. Mock, Hui Deng, Laura H. Heitman, Mark Connor, Vincenzo Di Marzo, Jürg Gertsch, Aron H. Lichtman, Mauro Maccarrone, Pal Pacher, Michelle Glass, Mario van der Stelt
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
CB2 receptor agonists are developed as potential analgesics or immune-modulatory compounds. Here, the authors characterize the pharmacological properties of widely used CB2 receptor agonists and antagonists, recommending three that appear most suitab
Externí odkaz:
https://doaj.org/article/d8fb448abc4444e3a10089f8b36e11e6
Autor:
Federica Storti, Katrin Klee, Vyara Todorova, Regula Steiner, Alaa Othman, Saskia van der Velde-Visser, Marijana Samardzija, Isabelle Meneau, Maya Barben, Duygu Karademir, Valda Pauzuolyte, Sanford L Boye, Frank Blaser, Christoph Ullmer, Joshua L Dunaief, Thorsten Hornemann, Lucia Rohrer, Anneke den Hollander, Arnold von Eckardstein, Jürgen Fingerle, Cyrille Maugeais, Christian Grimm
Publikováno v:
eLife, Vol 8 (2019)
Age-related macular degeneration (AMD) is a progressive disease of the retinal pigment epithelium (RPE) and the retina leading to loss of central vision. Polymorphisms in genes involved in lipid metabolism, including the ATP-binding cassette transpor
Externí odkaz:
https://doaj.org/article/992b60ec1c9e471eb4c01c575ad91eb9
Autor:
Richard Frederick Porter, Anna-Maria Szczesniak, James Thomas Toguri, Simon Gebremeskel, Brent Johnston, Christian Lehmann, Jürgen Fingerle, Benno Rothenhäusler, Camille Perret, Mark Rogers-Evans, Atsushi Kimbara, Matthias Nettekoven, Wolfgang Guba, Uwe Grether, Christoph Ullmer, Melanie E. M. Kelly
Publikováno v:
Molecules, Vol 24, Iss 18, p 3338 (2019)
(1) Background: The cannabinoid 2 receptor (CB2R) is a promising anti-inflammatory drug target and development of selective CB2R ligands may be useful for treating sight-threatening ocular inflammation. (2) Methods: This study examined the pharmacolo
Externí odkaz:
https://doaj.org/article/ef31d0daf6414bf7b58b32c719590b99
Autor:
Thais Gazzi, Benjamin Brennecke, Kenneth Atz, Claudia Korn, David Sykes, Gabriel Forn-Cuni, Patrick Pfaff, Roman C. Sarott, Matthias V. Westphal, Yelena Mostinski, Leonard Mach, Malgorzata Wasinska-Kalwa, Marie Weise, Bradley L. Hoare, Tamara Miljuš, Maira Mexi, Nicolas Roth, Eline J. Koers, Wolfgang Guba, André Alker, Arne C. Rufer, Eric A. Kusznir, Sylwia Huber, Catarina Raposo, Elisabeth A. Zirwes, Anja Osterwald, Anto Pavlovic, Svenja Moes, Jennifer Beck, Matthias Nettekoven, Irene Benito-Cuesta, Teresa Grande, Faye Drawnel, Gabriella Widmer, Daniela Holzer, Tom van der Wel, Harpreet Mandhair, Michael Honer, Jürgen Fingerle, Jörg Scheffel, Johannes Broichhagen, Klaus Gawrisch, Julián Romero, Cecilia J. Hillard, Zoltan V. Varga, Mario van der Stelt, Pal Pacher, Jürg Gertsch, Christoph Ullmer, Peter J. McCormick, Sergio Oddi, Herman P. Spaink, Mauro Maccarrone, Dmitry B. Veprintsev, Erick M. Carreira, Uwe Grether, Marc Nazaré
Publikováno v:
Gazzi, Thais; Brennecke, Benjamin; Atz, Kenneth; Korn, Claudia; Sykes, David; Forn-Cuni, Gabriel; Pfaff, Patrick; Sarott, Roman C; Westphal, Matthias V; Mostinski, Yelena; Mach, Leonard; Wasinska-Kalwa, Malgorzata; Weise, Marie; Hoare, Bradley L; Miljuš, Tamara; Mexi, Maira; Roth, Nicolas; Koers, Eline J; Guba, Wolfgang; Alker, André; ... (2022). Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe. Chemical Science, 13(19), pp. 5539-5545. The Royal Society of Chemistry 10.1039/d1sc06659e
Chemical Science, 13(19), 5539-5545
Chemical Science
Chemical Science, 13(19), 5539-5545
Chemical Science
Despite its essential role in the (patho)physiology of several diseases, CB2R tissue expression profiles and signaling mechanisms are not yet fully understood. We report the development of a highly potent, fluorescent CB2R agonist probe employing str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e61ac61b6e5b29da1ceeb545f2c056
http://hdl.handle.net/11697/192023
http://hdl.handle.net/11697/192023
Autor:
Torsten Schindler, Uwe Grether, Benjamin Brennecke, Marc Nazaré, Kenneth Atz, Jürgen Fingerle, Thais Gazzi, Pascal Kuner, Guy de Weck
Publikováno v:
Pharmaceutical patent analyst. 10(3)
The G-protein-coupled cannabinoid receptor type 2 (CB2R) is a key element of the endocannabinoid (EC) system. EC/CB2R signaling has significant therapeutic potential in major pathologies affecting humans such as allergies, neurodegenerative disorders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e04f913c83d4fa958e568f91f2e6364e
https://pubmed.ncbi.nlm.nih.gov/34111979
https://pubmed.ncbi.nlm.nih.gov/34111979
Autor:
Christian Bartelmus, Markus Bürkler, Uwe Grether, Christoph Ullmer, Julian Kretz, Irene Knuesel, Ahmed Haider, Roger Schibli, Luca Gobbi, Hazem Ahmed, Linjing Mu, Markus Weber, Adrienne Müller Herde, Kenneth Atz, Michael Honer, Wolfgang Guba, Claudia Keller, Simon M. Ametamey, Jürgen Fingerle, Andreas Brink
Publikováno v:
Journal of Medicinal Chemistry. 62:11165-11181
The cannabinoid type 2 (CB2) receptor has emerged as a valuable target for therapy and imaging of immune-mediated pathologies. With the aim to find a suitable radiofluorinated analogue of the previously reported CB2 positron emission tomography (PET)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afdeb6c2cf2905cd5704c6b236a756dd
https://doi.org/10.1021/acs.jmedchem.9b01280
https://doi.org/10.1021/acs.jmedchem.9b01280
Autor:
Mark Rogers-Evans, Matthias Nettekoven, Michel Bouvier, Uwe Grether, Franziska M. Heydenreich, Thais Gazzi, Anja Osterwald, Marc Nazaré, Atsushi Kimbara, Tamara Miljuš, Christoph Ullmer, Christian Le Gouill, Dmitry B. Veprintsev, Arne C. Rufer, Elisabeth A. Zirwes, Wolfgang Guba, Jürgen Fingerle
Cannabinoid CB1 and CB2 receptors are members of the G protein-coupled receptor family, which is the largest class of membrane proteins in the human genome. As part of the endocannabinoid system, they have many regulatory functions in the human body.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5b2aa7bcf5fc2433f62078972394e5
https://doi.org/10.1101/2020.11.09.375162
https://doi.org/10.1101/2020.11.09.375162
Autor:
Natasha L. Grimsey, Dmitry B. Veprintsev, Roman C. Sarott, Teresa Grande, Patrick Pfaff, Jürg Gertsch, Pal Pacher, Erick M. Carreira, Christoph Ullmer, Hermon Asmelash, Pattarin Hompluem, Svenja Moes, Daniela Holzer, Catarina Raposo, William R. Drobyski, Sylwia Huber, Jennifer Beck, Uwe Grether, Marc Nazaré, Claudia Korn, Zoltán Varga, Eline J. Koers, Jacopo Piovesan, Irene Benito-Cuesta, Klaus Gawrisch, Matthias Westphal, Benjamin Brennecke, Gabriella Widmer, Yurii Saroz, Eric Kusznir, Tom van der Wel, Anto Pavlovic, Kenneth Atz, Man C Vong, Tamara Miljuš, Peter J. McCormick, Mauro Maccarrone, Harpreet Mandhair, Samuel Ruiz de Martín Esteban, Sergio Oddi, Yelena Mostinski, Julián Romero, Elisabeth A. Zirwes, Anja Osterwald, Jürgen Fingerle, Cecilia J. Hillard, David A. Sykes, Alexei Yeliseev, Faye M. Drawnel, Mario van der Stelt, Marie Weise, Arne C. Rufer, Cheng-Yin Yuan, Thais Gazzi, Nicolas J. Roth, Michael Honer, Wolfgang Guba
Publikováno v:
Journal of the American Chemical Society
Journal of the American Chemical Society, 142(40), 16953-16964
Journal of the American Chemical Society, 142(40), 16953-16964
Pharmacological modulation of cannabinoid type 2 receptor (CB2R) holds promise for the treatment of numerous conditions, including inflammatory diseases, autoimmune disorders, pain, and cancer. Despite the significance of this receptor, researchers l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1774cb215365081fabff5fd4b151b22f
http://hdl.handle.net/11697/158602
http://hdl.handle.net/11697/158602
Autor:
Faye M. Drawnel, Jürgen Fingerle, Cecilia J. Hillard, David A. Sykes, Erick M. Carreira, Yurii Saroz, Christoph Ullmer, Natasha L. Grimsey, Daniela Holzer, Maira Mexi, Anja Osterwald, Dmitry B. Veprintsev, Patrick Pfaff, André Anker, Irene Benito-Cuesta, Matthias Westphal, Klaus Gawrisch, Benjamin Brennecke, Marie Weise, Julián Romero, Jennifer Beck, Anto Pavlovic, Gabriella Widmer, Kenneth Atz, Peter J. McCormick, Harpreet Mandhair, Michael Honer, Uwe Grether, Wolfgang Guba, Pal Pacher, Svenja Moes, Sylwia Huber, Bradley L. Hoare, Arne C. Rufer, Yelena Mostinski, Mario van der Stelt, Jürg Gertsch, Mauro Maccarrone, Claudia Korn, Roman C. Sarott, Elisabeth A. Zirwes, Catarina Raposo, Zoltán Varga, Tamara Miljuš, Thais Gazzi, Tom van der Wel, Teresa Grande, Eric Kusznir, Sergio Oddi, Marc Nazaré
Cannabinoid type 2 receptor (CB2R) is a fundamental part of the endocannabinoid signaling system (eCB system), and is known to play an important role in tissue injury, inflammation, cancer and pain. In stark contrast to its significance, the underlyi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3cac06b852c3e7933e52745f95a639
https://doi.org/10.26434/chemrxiv.10283027.v1
https://doi.org/10.26434/chemrxiv.10283027.v1