Molecular identification of falciparum malaria and human tuberculosis co-infections in mummies from the Fayum depression (Lower Egypt).

Autor: Albert Lalremruata, Markus Ball, Raffaella Bianucci, Beatrix Welte, Andreas G Nerlich, Jürgen F J Kun, Carsten M Pusch

Publikováno v: PLoS ONE, Vol 8, Iss 4, p e60307 (2013)

Due to the presence of the lake Quarun and to the particular nature of its irrigation system, it has been speculated that the Fayum, a large depression 80 kilometers south-west of modern Cairo, was exposed to the hazards of malaria in historic times.

Externí odkaz: https://doaj.org/article/1515afa126154ca585521a0a5f81e373

Plasmodium falciparum-infected erythrocytes induce granzyme B by NK cells through expression of host-Hsp70.

Autor: Evelyn Böttger, Gabriele Multhoff, Jürgen F J Kun, Meral Esen

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e33774 (2012)

In the early immune response to Plasmodium falciparum-infected erythrocytes (iRBC), Natural Killer (NK) cells are activated, which suggests an important role in innate anti-parasitic immunity. However, it is not well understood whether NK cells direc

Externí odkaz: https://doaj.org/article/d6efbceb987d4ce2ac84d91b46d0616b

Ficolin-2 levels and FCN2 haplotypes influence hepatitis B infection outcome in Vietnamese patients.

Autor: Tong V Hoang, Nguyen L Toan, Le H Song, Eman Abou Ouf, C-Thomas Bock, Peter G Kremsner, Jürgen F J Kun, T P Velavan

Publikováno v: PLoS ONE, Vol 6, Iss 11, p e28113 (2011)

Human Ficolin-2 (L-ficolins) encoded by FCN2 gene is a soluble serum protein that plays an important role in innate immunity and is mainly expressed in the liver. Ficolin-2 serum levels and FCN2 single nucleotide polymorphisms were associated to seve

Externí odkaz: https://doaj.org/article/f32a91fc437b4bee9b82e34c33dd0ab1

Susceptibility to Leprosy is Associated with M-ficolin Polymorphisms

Autor: Ewalda von Rosen Seeling Stahlke, Jürgen F. J. Kun, Maria Iolanda N Sanchez, Steffen Thiel, Iara J.T. Messias-Reason, Jens C. Jensenius, Angelica Beate Winter Boldt, Marcelo Távora Mira, Flávia Costa Prevedello, Rudi Steffensen

Publikováno v: Boldt, A B W, Sanchez, M I N, Stahlke, E R S, Steffensen, R, Thiel, S, Jensenius, J C, Prevedello, F C, Mira, M T, Kun, J F J & Messias-Reason, I J T 2013, ' Susceptibility to leprosy is associated with M-ficolin polymorphisms ', Journal of Clinical Immunology, vol. 33, no. 1, pp. 210-9 . https://doi.org/10.1007/s10875-012-9770-4
Boldt, A B W, Sanchez, M I N, Stahlke, E R S, Steffensen, R, Thiel, S, Jensenius, J C, Prevedello, F C, Mira, M T, Kun, J F J & Messias-Reason, I J T 2013, ' Susceptibility to Leprosy is Associated with M-ficolin Polymorphisms ', Journal of Clinical Immunology, vol. 33, no. 1, pp. 210-9 . https://doi.org/10.1007/s10875-012-9770-4

PURPOSE: Mycobacterium leprae exploits complement activation and opsonophagocytosis to infect phagocytes. M-ficolin is encoded by the FCN1 gene and initiates the lectin pathway on monocyte surfaces. We investigated FCN1 promoter polymorphisms that co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a5949b3deed1936c788a7be83208b2
https://doi.org/10.1007/s10875-012-9770-4

Multiplex sequence-specific polymerase chain reaction reveals new MASP2 haplotypes associated with MASP-2 and MAp19 serum levels

Autor: Rudi Steffensen, Iara J.T. Messias-Reason, C. Grisbach, Jürgen F. J. Kun, Angelica Beate Winter Boldt, Jens C. Jensenius, Steffen Thiel

Publikováno v: Boldt, A B W, Grisbach, C, Steffensen, R N, Thiel, S, Kun, J F J, Jensenius, J C & Messias-Reason, I J T 2011, ' Multiplex sequence-specific polymerase chain reaction reveals new MASP2 haplotypes associated with MASP-2 and MAp19 serum levels ', Human Immunology, vol. 72, no. 9, pp. 753-60 . https://doi.org/10.1016/j.humimm.2011.05.015

Deficiency of mannan-binding lectin-associated serine protease 2 (MASP-2) has been associated with infections, whereas high levels appear to increase the risk of inflammatory disorders. Nevertheless, MASP2 haplotypes have been poorly investigated. To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711f8bfa1f3989eb8c27edbb7a0dc614
https://doi.org/10.1016/j.humimm.2011.05.015