Výsledky vyhledávání - "Jürgen Christoph Von Kleist-Retzow"

Akademický článek

Bezafibrate Reduces Elevated Hepatic Fumarate in Insulin-Deficient Mice

Autor: Andras Franko, Martin Irmler, Cornelia Prehn, Silke S. Heinzmann, Philippe Schmitt-Kopplin, Jerzy Adamski, Johannes Beckers, Jürgen-Christoph von Kleist-Retzow, Rudolf Wiesner, Hans-Ulrich Häring, Martin Heni, Andreas L. Birkenfeld, Martin Hrabě de Angelis

Publikováno v: Biomedicines, Vol 10, Iss 3, p 616 (2022)

Glucotoxic metabolites and pathways play a crucial role in diabetic complications, and new treatment options which improve glucotoxicity are highly warranted. In this study, we analyzed bezafibrate (BEZ) treated, streptozotocin (STZ) injected mice, w

Externí odkaz: https://doaj.org/article/b41a9e1a191b4428813e24dc91366f22

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Bezafibrate Reduces Elevated Hepatic Fumarate in Insulin-Deficient Mice

Publikováno v: Biomedicines 10:616 (2022)
Biomedicines; Volume 10; Issue 3; Pages: 616

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4778f0e6bd866c68c810c3ce0355be69
https://mediatum.ub.tum.de/doc/1657636/document.pdf

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Akademický článek

Impaired Insulin Signaling is Associated with Hepatic Mitochondrial Dysfunction in IR+/−-IRS-1+/− Double Heterozygous (IR-IRS1dh) Mice

Autor: Andras Franko, Alexander Kunze, Marlen Böse, Jürgen-Christoph von Kleist-Retzow, Mats Paulsson, Ursula Hartmann, Rudolf J. Wiesner

Publikováno v: International Journal of Molecular Sciences, Vol 18, Iss 6, p 1156 (2017)

Mitochondria play a pivotal role in energy metabolism, but whether insulin signaling per se could regulate mitochondrial function has not been identified yet. To investigate whether mitochondrial function is regulated by insulin signaling, we analyze

Externí odkaz: https://doaj.org/article/0ccb52277b664d86b7a986eb19c53d22

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Alice im digitalen Wunderland: pädiatrische Lehre in der COVID-19-Pandemie : Eine Umfrage und Stellungnahme der AG Lehre der Deutschen Gesellschaft für Kinder- und Jugendmedizin (DGKJ)

Autor: Joachim Kreuder, Norbert Graf, Hans Martin Bosse, Thomas Fischbach, Martin Häusler, Jürgen-Christoph von Kleist-Retzow

Publikováno v: Monatsschrift Kinderheilkunde 169(2), 151-158 (2021). doi:10.1007/s00112-020-01076-7 special issue: "Pädiatrische Dermatologie"

Monatsschrift Kinderheilkunde 169(2), 151-158 (2021). doi:10.1007/s00112-020-01076-7 special issue: "Pädiatrische Dermatologie"
Published by Springer, Berlin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f428a029c128e5c50309ff941a76a5d

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Clinical trial of L-Carnitine and valproic acid in spinal muscular atrophy type I

Publikováno v: Muscle & Nerve. 57:193-199

Introduction:To explore safety and therapeutic potential of L-carnitine and valproic acid (VPA) in infants with spinal muscular atrophy (SMA). Methods: Open-label phase 2 multicenter trial of L-carnitine and VPA in infants with SMA type I with retros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d836022c9ca6aee9eb592cd2cf9ae2ae
https://doi.org/10.1002/mus.25776

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Clinical trial of L-Carnitine and valproic acid in spinal muscular atrophy type I

Publikováno v: Musclenerve. 57(2)

The aim of this study was to determine the safety and therapeutic potential of L-carnitine and valproic acid (VPA) in infants with spinal muscular atrophy (SMA).Our investigation was an open-label phase 2 multicenter trial of L-carnitine and VPA in i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::75c293ab2903738e7c50b6f54f5912b2
https://pubmed.ncbi.nlm.nih.gov/28833236

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Negative regulation of mitochondrial transcription by mitochondrial topoisomerase I

Autor: Christian Mielke, Heiner Schaal, Frank Hillebrand, Rudolf J. Wiesner, Ilaria Dalla Rosa, Fritz Boege, Morten O. Christensen, Stefan Sobek, Hongliang Zhang, Faiza Kalfalah, Beatrice Bornholz, Yves Pommier, Jürgen-Christoph von Kleist-Retzow

Publikováno v: Nucleic Acids Research

Mitochondrial topoisomerase I is a genetically distinct mitochondria-dedicated enzyme with a crucial but so far unknown role in the homeostasis of mitochondrial DNA metabolism. Here, we present data suggesting a negative regulatory function in mitoch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ee8cf32a9791936540e52bda1c1a2b
https://doi.org/10.1093/nar/gkt768

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Clinical pattern, mutations and in vitro residual activity in 33 patients with severe 5, 10 methylenetetrahydrofolate reductase (MTHFR) deficiency

Publikováno v: JOURNAL OF INHERITED METABOLIC DISEASE
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
Journal of inherited metabolic disease
Journal of Inherited Metabolic Disease, 39(1), 115-124. SPRINGER

BACKGROUND: Severe methylenetetrahydrofolate reductase (MTHFR) deficiency is a rare (1.5% control) in vitro residual enzyme activity had mainly psychiatric symptoms, mental retardation, myelopathy, ataxia and spasticity. Treatment with various combin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde7d103e5d38e4744894aa67edb4b54
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13399

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Autor: Georgia Vlahou, Jürgen-Christoph von Kleist-Retzow, Rudolf J. Wiesner, Marek Eliáš, Francisco Rivero

Publikováno v: European Journal of Cell Biology. 90:342-355

Ras-related GTPases of the Miro family have been implicated in mitochondrial homeostasis and microtubule-dependent transport. They consist of two GTP-binding domains separated by calcium-binding motifs and of a C-terminal transmembrane domain that ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed95889275ce0d057805fb054af0c042
https://doi.org/10.1016/j.ejcb.2010.10.012

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