Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jürgen Boer"'
Autor:
Dorothea Piecha, Frank Richter, Bert Nolte, Darrell Nix, Gallagher Brian, Arthur G. Taveras, Gabriel Becher, Matthias Hochgürtel, Michael Essers, Xinyuan Wu, Tim Feuerstein, Ralf Biesinger, Alison M. Bendele, Hongbo Deng, Rory Dodd, Christian Gege, Lixia Jin, Andreas Timmermann, Brian Korniski, Harald Bluhm, Michael Hofmann, Bing Xia, Juergen Weik, Andrew Kiely, Matthias F. Schneider, Jürgen Boer, Heiko Kroth, Andreas Jaworski, Timothy Powers, Vijaykumar M. Baragi, Christoph Steeneck, Irving Sucholeiki, Joshua Van Veldhuizen
Publikováno v:
Arthritis & Rheumatism. 60:2008-2018
Objective Matrix metalloproteinases (MMPs) have long been considered excellent targets for osteoarthritis (OA) treatment. However, clinical utility of broad-spectrum MMP inhibitors developed for this purpose has been restricted by dose-limiting muscu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55c77f7395ffca241b3ca3322d33b21
https://doi.org/10.1002/art.24629
https://doi.org/10.1002/art.24629
Publikováno v:
Angewandte Chemie International Edition. 44:927-932
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108a262d894a8f319c725989edf541b8
https://doi.org/10.1002/anie.200461182
https://doi.org/10.1002/anie.200461182
Publikováno v:
Journal of Medicinal Chemistry. 46:5752-5762
As part of our ongoing research in the development of alpha4beta7 integrin antagonists, we are interested in peptidomimetics based on a rigid scaffold to allow the display of essential side chains in a suitable binding conformation while eliminating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c13502e803a52f087e0f6e2b92d33cf
https://doi.org/10.1021/jm020487h
https://doi.org/10.1021/jm020487h
Publikováno v:
Angewandte Chemie. 113:3988-3991
A cyclic peptide role model was used for the design and synthesis of a new class of biologically active and α4 -selective integrin antagonists (e.g. 1) based on β-D-mannose. These carbohydrate-based peptidomimetics were synthesized to include the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2d02bb30aa0bed4061a3eab609651b
https://doi.org/10.1002/1521-3757(20011015)113:20<3988::aid-ange3988>3.0.co
https://doi.org/10.1002/1521-3757(20011015)113:20<3988::aid-ange3988>3.0.co
Autor:
Brian Korniski, Taveras Arthur G, Jürgen Boer, Christian Gege, Gallagher Brian, Harald Bluhm, Vijaykumar M. Baragi, Christoph Steeneck, Bagna Bao, Timothy Powers
Publikováno v:
Journal of medicinal chemistry. 55(2)
Osteoarthritis (OA) is a nonsystemic disease for which no oral or parenteral disease-modifying osteoarthritic drug (DMOAD) is currently available. Matrix metalloproteinase 13 (MMP-13) has attracted attention as a target with disease-modifying potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d4248500b2bcb7f74f3317bee4ab01
https://pubmed.ncbi.nlm.nih.gov/22175799
https://pubmed.ncbi.nlm.nih.gov/22175799
Autor:
Dirk, Gottschling, Jürgen, Boer, Luciana, Marinelli, Georg, Voll, Melina, Haupt, Anja, Schuster, Bernhard, Holzmann, Horst, Kessler
Publikováno v:
Chembiochem : a European journal of chemical biology. 3(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ad7b75dd9239cca631409d123da04cbb
https://pubmed.ncbi.nlm.nih.gov/12325015
https://pubmed.ncbi.nlm.nih.gov/12325015
Publikováno v:
Angewandte Chemie (International ed. in English). 41(16)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::108911c0c2bfb3b5a8f460bace33252f
https://pubmed.ncbi.nlm.nih.gov/12203440
https://pubmed.ncbi.nlm.nih.gov/12203440
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(23)
A qualitative cellular solid-phase binding assay for screening α4β7 integrin antagonists attached via photolinker to TentaGel® Macrobeads has been developed. An activation of the integrins with Mn 2+ was necessary to achieve binding to the bead bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::182c588d0c282ea772f1c1b10089c1fd
https://pubmed.ncbi.nlm.nih.gov/11714596
https://pubmed.ncbi.nlm.nih.gov/11714596
Publikováno v:
Angewandte Chemie (International ed. in English). 40(20)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::936522778461c7f3d63e251fd4389194
https://pubmed.ncbi.nlm.nih.gov/11668559
https://pubmed.ncbi.nlm.nih.gov/11668559
Autor:
Bernhard Holzmann, Jürgen Boer, Anja Schuster, Monika Semmrich, Dirk Gottschling, Horst Kessler
Publikováno v:
Journal of medicinal chemistry. 44(16)
Interactions of the integrins alpha(4)beta(7) with its cognate ligand mucosal addressin cell adhesion molecule-1 (MAdCAM-1) play a crucial role in the development of mucosa-associated lymphoid organs, in the generation of mucosal immune responses, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::713bd3e19a08b99f2a04926f3883eb01
https://pubmed.ncbi.nlm.nih.gov/11472212
https://pubmed.ncbi.nlm.nih.gov/11472212