Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jürgen Besemer"'
Autor:
Berndt Oberhauser, Hanna Harant, Christiane Dascher-Nadel, Katharina Marquardt, Erwin P. Schreiner, Ivan J. D. Lindley, Shirley Wang, Jan E. de Vries, Carolyn A. Foster, Jürgen Besemer
Publikováno v:
Nature. 436:290-293
Increased expression of vascular cell adhesion molecule 1 (VCAM1) is associated with a variety of chronic inflammatory conditions, making its expression and function a target for therapeutic intervention1,2,3. We have recently identified CAM741, a de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eef67ae52898311a9f1915d7e063b68
https://doi.org/10.1038/nature03670
https://doi.org/10.1038/nature03670
Publikováno v:
Cytokine. 10:1-12
Interleukin 8 (IL-8) is a member of the CXC subfamily of chemokines which attracts and activates preferentially neutrophilic granulocytes. At nanomolar concentrations monomeric and dimeric forms of the molecule are in equilibrium, with the monomer be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21bc1de580d9f8cc887428f4141ad2c0
https://doi.org/10.1006/cyto.1997.0251
https://doi.org/10.1006/cyto.1997.0251
Autor:
Thomas Kirsch, Paul Rösch, Bettina Schmitt, Ivan J. D. Lindley, Markus Horcher, Heinrich Sticht, Jürgen Besemer, Manfred Auer
Publikováno v:
Scopus-Elsevier
A 72-amino-acid chimeric protein, Chi1, was constructed from the N-terminal part of interleukin 8, IL-8-(1-53), and the C-terminal part of melanoma growth stimulatory activity, MGSA-(54-72). Chi1 protein showed receptor-binding specificity and biolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4875ce205e6259d9fcb2f6e23f445f
https://doi.org/10.1111/j.1432-1033.1996.00026.x
https://doi.org/10.1111/j.1432-1033.1996.00026.x
Publikováno v:
Journal of Leukocyte Biology. 55:763-770
By chemical cross-linking experiments we show that at physiologically relevant concentrations IL-8 and NAP-2 monomers are in an equilibrium with dimers and even oligomers (Kd 300–800 nM). Oligomerization seems to be more prevalent for IL-8 than for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b713dc1f32e31e878cacb802565f5d
https://doi.org/10.1002/jlb.55.6.763
https://doi.org/10.1002/jlb.55.6.763
Publikováno v:
Cytokine. 5:512-519
The human neutrophil activating peptides-1 and -2 (NAP-1/IL-8, NAP-2) are two structurally and functionally related members of the chemokine cytokine family. They are chemoattractants and activators of neutrophils and exert their effects by binding t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4422a25a410305589a217fbe219329c3
https://doi.org/10.1016/1043-4666(93)90043-5
https://doi.org/10.1016/1043-4666(93)90043-5
Publikováno v:
Leukemia Research. 16:1181-1186
The majority of patients suffering from myelodysplastic syndromes (MDS) die of complications due to cytopenia. Clinical trials have demonstrated that in an essential number of MDS patients cytopenia can be ameliorated by exogenously supplied growth f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4543d9353b1c71bf831faee783ac5cab
https://doi.org/10.1016/0145-2126(92)90116-o
https://doi.org/10.1016/0145-2126(92)90116-o
Publikováno v:
Biochemical and Biophysical Research Communications. 180:301-307
Summary Neutrophil receptor(s) for neutrophil activating peptides 1 and 2 were studied by competition binding experiments with radiolabeled NAP-1 and NAP-2 preparations. NAP-1 bound with one affinity, NAP-2 with two quite different affinities, to com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8dd856108106c815a5319df96caaf87
https://doi.org/10.1016/s0006-291x(05)81292-6
https://doi.org/10.1016/s0006-291x(05)81292-6
Autor:
Joerg Kallen, Charles Lam, Ivan J. D. Lindley, Susan R. Owens, Sabine Pfeffer, Antal Rot, Manfred Auer, Gerald Ehn, Jürgen Besemer, Heinz Aschauer, Erich Wasserbauer
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461362838
After its identification in 1987 as a novel neutrophil-activating cytokine, interleukin-8 (IL-8) was the center of interest of a large variety of interdisciplinary scientists for study of its action in vitro and in vivo (1,2,3,4). Soon it became clea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0642a577bdcc3d95786f03c3ed435668
https://doi.org/10.1007/978-1-4615-2952-1_18
https://doi.org/10.1007/978-1-4615-2952-1_18
Publikováno v:
Nucleic Acids Research. 8:5825-5833
Three derivatives of mutant ga10P-308::IS2-I of Escherichia coli were characterized by DNA sequence analysis. Deletions and DNA sequence rearrangements were observed which apparently were initiated at short A-T rich inverted repeats within IS2. Two o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::705252ea1fc01557a30ca5d8694dd927
https://doi.org/10.1093/nar/8.23.5825
https://doi.org/10.1093/nar/8.23.5825
Autor:
Maria Herpers, Jürgen Besemer
Publikováno v:
Molecular and General Genetics MGG. 151:295-304
Phenotypic revertants of galOP::IS1 and galOP::IS2 mutations have been isolated after mutagenesis with nitrosoguanidine, they are probably caused by mutations in gene suA. The polarity suppressor mutations described in this study and a known mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de5bd6c5c8269c8944d1fa204d85c8ff
https://doi.org/10.1007/bf00268793
https://doi.org/10.1007/bf00268793