Uncovering the Relationship between Selenium Status, Age, Health, and Dietary Habits: Insights from a Large Population Study including Nonagenarian Offspring from the MARK-AGE Project

Autor: Robertina Giacconi, Francesco Piacenza, Valentina Aversano, Michele Zampieri, Alexander Bürkle, María Moreno Villanueva, Martijn E. T. Dollé, Eugène Jansen, Tilman Grune, Efstathios S. Gonos, Claudio Franceschi, Miriam Capri, Birgit Weinberger, Ewa Sikora, Olivier Toussaint, Florence Debacq-Chainiaux, Wolfgang Stuetz, Pieternella Eline Slagboom, Jürgen Bernhardt, Maria Luisa Fernández-Sánchez, Mauro Provinciali, Marco Malavolta

Publikováno v: Nutrients, Vol 15, Iss 9, p 2182 (2023)

An inadequate selenium (Se) status can accelerate the aging process, increasing the vulnerability to age-related diseases. The study aimed to investigate plasma Se and Se species in a large population, including 2200 older adults from the general pop

Externí odkaz: https://doaj.org/article/c38d65ce458c4d58be8523df5a67876b

Circulating cell-free DNA in health and disease - the relationship to health behaviours, ageing phenotypes and metabolomics

Autor: Laura Kananen, Mikko Hurme, Alexander Bürkle, Maria Moreno-Villanueva, Jürgen Bernhardt, Florence Debacq-Chainiaux, Beatrix Grubeck-Loebenstein, Marco Malavolta, Andrea Basso, Francesco Piacenza, Sebastiano Collino, Efstathios S. Gonos, Ewa Sikora, Daniela Gradinaru, Eugene H. J. M. Jansen, Martijn E. T. Dollé, Michel Salmon, Wolfgang Stuetz, Daniela Weber, Tilman Grune, Nicolle Breusing, Andreas Simm, Miriam Capri, Claudio Franceschi, Eline Slagboom, Duncan Talbot, Claude Libert, Jani Raitanen, Seppo Koskinen, Tommi Härkänen, Sari Stenholm, Mika Ala-Korpela, Terho Lehtimäki, Olli T. Raitakari, Olavi Ukkola, Mika Kähönen, Marja Jylhä, Juulia Jylhävä

Publikováno v: GEROSCIENCE
Kananen, L, Hurme, M, Bürkle, A, Moreno-Villanueva, M, Bernhardt, J, Debacq-Chainiaux, F, Grubeck-Loebenstein, B, Malavolta, M, Basso, A, Piacenza, F, Collino, S, Gonos, E S, Sikora, E, Gradinaru, D, Jansen, E H J M, Dollé, M E T, Salmon, M, Stuetz, W, Weber, D, Grune, T, Breusing, N, Simm, A, Capri, M, Franceschi, C, Slagboom, E, Talbot, D, Libert, C, Raitanen, J, Koskinen, S, Härkänen, T, Stenholm, S, Ala-Korpela, M, Lehtimäki, T, Raitakari, O T, Ukkola, O, Kähönen, M, Jylhä, M & Jylhävä, J 2022, ' Circulating cell-free DNA in health and disease — the relationship to health behaviours, ageing phenotypes and metabolomics ', GeroScience, vol. 45, no. 1, pp. 85-103 . https://doi.org/10.1007/s11357-022-00590-8

Circulating cell-free DNA (cf-DNA) has emerged as a promising biomarker of ageing, tissue damage and cellular stress. However, less is known about health behaviours, ageing phenotypes and metabolic processes that lead to elevated cf-DNA levels. We so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1937b684e94cf6fd814da6a2766df5
https://biblio.ugent.be/publication/01H3MEVG6Y0Y2FEYN73BRTMM0J/file/01H3MEYCVHDKPXJFS8FDX6YT26

Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE study

Autor: Martijn E.T. Dollé, Albert Wong, W M Monique Verschuren, Nicolle Breusing, Beatrix Grubeck-Loebenstein, Francesco Piacenza, Florence Debacq-Chainiaux, Efstathios S. Gonos, Andrea Basso, P. Eline Slagboom, Wolfgang Stuetz, Eugène H.J.M. Jansen, Maria Moreno-Villanueva, Tilman Grune, M. Liset Rietman, Alexander Bürkle, Jürgen Bernhardt, Annemieke M.W. Spijkerman, Harry van Steeg, Thilo Sindlinger, Claudio Franceschi, Marco Malavolta, Sebastiano Collino, Daniela Weber, Olivier Toussaint, Ewa Sikora

Publikováno v: Mechanisms of Ageing and Development, 177, 135. Elsevier Ireland Ltd

Frailty among elderly people leads to an increased risk for negative health outcomes. To prevent frailty, we need a better understanding of the underlying mechanisms and early detection of individuals at risk. Both may be served by identifying candid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed12b8c1e8e6baa496c7b0939055f31
https://doi.org/10.1016/j.mad.2018.04.007

Do low molecular weight antioxidants contribute to the Protection against oxidative damage? The interrelation between oxidative stress and low molecular weight antioxidants based on data from the MARK-AGE study

Autor: Ron Kohen, Ilya Pinchuk, Nicolle Breusing, Daniela Gradinaru, Martijn E.T. Dollé, Efstathios S. Gonos, Mikko Hurme, Maria Moreno-Villanueva, Wolfgang Stuetz, Claudio Franceschi, Dov Lichtenberg, Eugène H.J.M. Jansen, Miriam Capri, Florence Debacq-Chainiaux, Tilman Grune, Christiane Schön, Daniela Weber, Beatrix Grubeck-Loebenstein, Ewa Sikora, Jürgen Bernhardt, Alexander Bürkle

Publikováno v: Archives of biochemistry and biophysics. 713

A redox steady state is important in maintaining vital cellular functions and is therefore homeostatically controlled by a number of antioxidative agents, the most important of which are enzymes. Oxidative Stress (OS) is associated with (or/and cause

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696d6bfc8906ecf6b88bf2b25ae4655b
https://pubmed.ncbi.nlm.nih.gov/34662556

Prevalence and loads of torquetenovirus in the European MARK-AGE study population

Autor: Alexander Bürkle, Antti Hervonen, Martijn E.T. Dollé, Ewa Sikora, Claudio Franceschi, Efstathios S. Gonos, Wolfgang Stuetz, Eugenio Mocchegiani, Marco Malavolta, Miriam Capri, Eline Slagboom, Pietro Giorgio Spezia, Mauro Provinciali, Mikko Hurme, Magdalena Dudkowska, Christiane Schön, Mauro Pistello, Maria Moreno-Villanueva, Olivier Toussaint, Fabrizio Maggi, Nicolle Breusing, Jürgen Bernhardt, Eugène H.J.M. Jansen, Francesco Piacenza, Robertina Giacconi, Lisa Macera, Beatrix Grubeck-Loebenstein, Florence Debacq-Chainiaux, Dorota Janiszewska, Andrea Basso, Tilman Grune

Publikováno v: The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 75(10), 1838-1845. OXFORD UNIV PRESS INC

Torquetenovirus (TTV) viremia has been associated with increased mortality risk in the elderly population. This work aims to investigate TTV viremia as a potential biomarker of immunosenescence. We compared levels of circulating TTV in 1813 participa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceaa63878817e328cbce9a1be3995f15
https://hdl.handle.net/1887/3182200