Zobrazeno 1 - 10
of 182
pro vyhledávání: '"Jürgen B, Bulitta"'
Autor:
Jan Naseer Kaur, Navaldeep Singh, Nicholas M. Smith, Jack F. Klem, Raymond Cha, Yinzhi Lang, Liang Chen, Barry Kreiswirth, Patricia N. Holden, Jürgen B. Bulitta, Brian T. Tsuji
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Antimicrobial resistance has emerged as one of the leading public health threats of the twenty-first century. Gram-negative pathogens have been a major contributor to the declining efficacy of antibiotics through both acquired resistance and
Externí odkaz:
https://doaj.org/article/7f6679478e6646e4b2715cd7705e81b5
Publikováno v:
Molecules, Vol 27, Iss 5, p 1518 (2022)
Infections due to Gram-negative bacteria are increasingly dangerous due to the spread of multi-drug resistant strains, emphasizing the urgent need for new antibiotics with alternative modes of action. We have previously identified a novel class of an
Externí odkaz:
https://doaj.org/article/e98d0e06ad034f5f815f652b5442de18
Autor:
Tae Hwan Kim, Xun Tao, Bartolome Moya, Yuanyuan Jiao, Kari B. Basso, Jieqiang Zhou, Yinzhi Lang, Dhruvitkumar S. Sutaria, Alexandre P. Zavascki, Afonso L. Barth, Stephanie M. Reeve, Herbert P. Schweizer, Deanna Deveson Lucas, John D. Boyce, Robert A. Bonomo, Richard E. Lee, Beom Soo Shin, Arnold Louie, George L. Drusano, Jürgen B. Bulitta
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT Poor penetration through the outer membrane (OM) of Gram-negative bacteria is a major barrier of antibiotic development. While β-lactam antibiotics are commonly used against Klebsiella pneumoniae and Enterobacter cloacae, there are limited
Externí odkaz:
https://doaj.org/article/15920c889cbe439dba2992e6e5cf4623
Autor:
Jessica R. Tait, Hajira Bilal, Kate E. Rogers, Yinzhi Lang, Tae-Hwan Kim, Jieqiang Zhou, Steven C. Wallis, Jürgen B. Bulitta, Carl M. J. Kirkpatrick, David L. Paterson, Jeffrey Lipman, Phillip J. Bergen, Jason A. Roberts, Roger L. Nation, Cornelia B. Landersdorfer
Publikováno v:
Antibiotics, Vol 11, Iss 1, p 101 (2022)
We evaluated piperacillin-tazobactam and tobramycin regimens against Pseudomonas aeruginosa isolates from critically ill patients. Static-concentration time-kill studies (SCTK) assessed piperacillin-tazobactam and tobramycin monotherapies and combina
Externí odkaz:
https://doaj.org/article/2c239a05246f49388e27fd8db173a442
Autor:
Silvia López-Argüello, Maria Montaner, Alaa RM. Sayed, Antonio Oliver, Jürgen B. Bulitta, Bartolome Moya
Publikováno v:
Antimicrobial Agents and Chemotherapy.
The β-lactam antibiotics have been successfully used for decades to combat susceptible Pseudomonas aeruginosa , which has a notoriously difficult to penetrate outer membrane (OM). However, there is a dearth of data on target site penetration and cov
Autor:
Yuanyuan Jiao, Jun Yan, Michael Vicchiarelli, Dhruvitkumar S. Sutaria, Peggy Lu, Zeferino Reyna, Brad Spellberg, Robert A. Bonomo, George L. Drusano, Arnold Louie, Brian M. Luna, Jürgen B. Bulitta
Publikováno v:
Antimicrobial Agents and Chemotherapy. 67
Polymyxin B is a “last-line-of-defense” antibiotic approved in the 1960s. However, the population pharmacokinetics (PK) of its four main components has not been reported in infected mice. We aimed to determine the PK of polymyxin B1, B1-Ile, B2,
Autor:
Stefanie K. Drescher, Yuanyuan Jiao, Mong-Jen Chen, Abhinav Kurumaddali, Jie Shao, Elham Amini, Günther Hochhaus, Jürgen B. Bulitta
Publikováno v:
Pharmaceutical Research.
Autor:
Nicholas M. Smith, Katie Rose Boissonneault, Liang Chen, Vidmantas Petraitis, Ruta Petraitiene, Xun Tao, Jieqiang Zhou, Yinzhi Lang, Povilas Kavaliauskas, Zackery P. Bulman, Patricia N. Holden, Raymond Cha, Jürgen B. Bulitta, Barry N. Kreiswirth, Thomas J. Walsh, Brian T. Tsuji
Publikováno v:
Antimicrob Agents Chemother
Metallo-β-lactamase (MBL)-producing Gram-negative bacteria cause infections associated with high rates of morbidity and mortality. Currently, a leading regimen to treat infections caused by MBL-producing bacteria is aztreonam combined with ceftazidi
Autor:
Evelyn J. Franco, Xun Tao, Kaley C. Hanrahan, Jieqiang Zhou, Jürgen B. Bulitta, Ashley N. Brown
Publikováno v:
Microorganisms, Vol 9, Iss 2, p 307 (2021)
Chikungunya virus (CHIKV) is an alphavirus associated with a broad tissue tropism for which no antivirals or vaccines are approved. This study evaluated the antiviral potential of favipiravir (FAV), interferon-alpha (IFN), and ribavirin (RBV) against
Externí odkaz:
https://doaj.org/article/2f415b893df044c8a85e0b0c29312966
Autor:
Jordan L Kennedy, Jürgen B Bulitta, Kevin Chatham-Stephens, Marissa K Person, Rachel Cook, Thitipong Mongkolrattanothai, Eunjeong Shin, Patricia Yu, Maria E Negron, William A Bower, Katherine Hendricks
Publikováno v:
Clin Infect Dis
Background Anthrax is endemic to many countries, including the United States. The causative agent, Bacillus anthracis, poses a global bioterrorism threat. Without effective antimicrobial postexposure prophylaxis (PEPAbx) and treatment, the mortality