Neutralization of Macrophage Migration Inhibitory Factor (MIF) by Fully Human Antibodies Correlates with Their Specificity for the β-Sheet Structure of MIF

Autor: Jurate Garbaraviciene, Thierry Calandra, Gerhard Antoine, Didier Le Roy, Wolf-Henning Boehncke, Michael Thiele, Clive R. Wood, Hartmut J. Ehrlich, Randolf Kerschbaumer, Thierry Roger, Manfred Rieger, Dirk Völkel, Jürgen Müllberg, Rene Hoet, Michael Dockal, Friedrich Scheiflinger, Helga Savidis-Dacho

Publikováno v: The Journal of biological chemistry
JOURNAL OF BIOLOGICAL CHEMISTRY
Journal of Biological Chemistry, Vol. 287, No 10 (2012) pp. 7446-7455

The macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that recently emerged as an attractive therapeutic target for a variety of diseases. A diverse panel of fully human anti-MIF antibodies was generated by selection from a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd75e6ea654d84e80bd66d12ab78738a
https://doi.org/10.1074/jbc.m111.329664

Rapid generation of functional human IgG antibodies derived from Fab-on-phage display libraries

Autor: Thomas, Jostock, Marc, Vanhove, Eddy, Brepoels, Rein, Van Gool, Marc, Daukandt, Anita, Wehnert, Rob, Van Hegelsom, Dan, Dransfield, Dan, Sexton, Mary, Devlin, Art, Ley, Hennie, Hoogenboom, Jürgen, Müllberg

Publikováno v: Journal of Immunological Methods. 289:65-80

We introduce a procedure for the rapid generation of fully human antibodies derived from “Fab-on-phage” display libraries. The technology is based on the compatibility of display vectors and IgG expression constructs, and allows reformatting of i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7550eafcc6076c01506c04918b0108b6
https://doi.org/10.1016/j.jim.2004.03.014

ULBPs, Novel MHC Class I–Related Molecules, Bind to CMV Glycoprotein UL16 and Stimulate NK Cytotoxicity through the NKG2D Receptor

Autor: N. Jan Chalupny, David Cosman, William C. Fanslow, Jürgen Müllberg, Richard J. Armitage, Claire L. Sutherland, Wilson Chin, Marek Kubin

Publikováno v: Immunity. 14:123-133

The human cytomegalovirus glycoprotein, UL16, binds to two members of a novel family of molecules, the ULBPs, and to the MHC class I homolog, MICB. The ULBPs are GPI-linked glycoproteins belonging to the extended MHC class I family but are only dista

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f45cf28db603203e9d404f00e5d68f5
https://doi.org/10.1016/s1074-7613(01)00095-4

Human herpes virus 8 interleukin-6 homologue triggers gp130 on neuronal and hematopoietic cells

Autor: Thomas Jostock, Katharina Götze, Petra Vollmer, Stefan Rose-John, Pia März, Jürgen Müllberg, Martina Fischer, Sabine Mechtersheimer, Christian Peschel, Peter R. Galle, Joachim Grötzinger, Suat Özbek, Susanne H. Hoischen, Till Geib

Publikováno v: European Journal of Biochemistry. 267:3604-3612

Human herpes virus-8 (HHV8) encodes a cytokine named viral interleukin-6 (vIL-6) that shares 25% amino-acid identity with its human homologue. Human IL-6 is known to be a growth and differentiation factor of lymphatic cells and plays a potential role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e5a95611d40eb32ec91660598d5c479
https://doi.org/10.1046/j.1432-1327.2000.01389.x

Receptor Recognition Sites of Cytokines Are Organized as Exchangeable Modules

Autor: Hugues Gascan, Stefan Rose-John, Petra Vollmer, Karl-Josef Kallen, Dorthe Aasland, Karl-Hermann Meyer zum Büschenfelde, Eric Lelièvre, Joachim Grötzinger, Jürgen Müllberg, Christoph Renné

Publikováno v: Journal of Biological Chemistry. 274:11859-11867

Interleukin-6 (IL-6) and ciliary neurotrophic factor (CNTF) are "4-helical bundle" cytokines of the IL-6 type family of neuropoietic and hematopoietic cytokines. IL-6 signals by induction of a gp130 homodimer (e.g. IL-6), whereas CNTF and leukemia in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1c40972befb76de6e4eae59d02569e0
https://doi.org/10.1074/jbc.274.17.11859