Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jürgen, Hellmann"'
Autor:
Lena Kasper, Frederic Pipp, Bettina Hanschke, Michael Schmitt, Stephanie Czasch, Enrico Vigna, Anindya Siddharta, Stefan Weigt, Barbara Emde, Jürgen Hellmann, Sven Jäckel
Publikováno v:
Journal of pharmacological and toxicological methods. 110
Introduction Gastrointestinal (GI) toxicity is still an issue within drug development, especially for novel oncology drugs. The identification of GI mucosal damage at an early stage with high sensitivity and specificity across preclinical species and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b67dc0c89dde1c19302a7c9b1cd2b7fd
https://pubmed.ncbi.nlm.nih.gov/33940165
https://pubmed.ncbi.nlm.nih.gov/33940165
Autor:
Anja Knippel, Jürgen Hellmann, Stefan Weigt, Stephanie Czasch, Anindya Siddharta, Michael Schmitt, Bettina Hanschke, Barbara Emde, Lena Kasper, Valentina Lai, Sven Jäckel
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 105:106863
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebb683caaf9b04a5ecaf1af47f3cfb4a
https://doi.org/10.1016/j.vascn.2020.106863
https://doi.org/10.1016/j.vascn.2020.106863
Autor:
Kerstin Fella, Michael Karas, Dietmar Waidelich, Matthias Glückmann, Michaela Kröger, Dietrich Merkel, Volker Kruft, Peter-Jürgen Kramer, Yvonne Walter, Jürgen Hellmann
Publikováno v:
PROTEOMICS. 7:1564-1574
Today, toxicoproteomics still relies mainly on 2-DE followed by MS for detection and identification of proteins, which might characterize a certain state of disease, indicate toxicity or even predict carcinogenicity. We utilized the classical 2-DE/MS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494011066889be0d624d28cca1e5f15e
https://doi.org/10.1002/pmic.200600836
https://doi.org/10.1002/pmic.200600836
Autor:
Kerstin Fella, Jürgen Hellmann, Michael Karas, Michaela Kröger, Matthias Glückmann, P.-J. Kramer
Publikováno v:
PROTEOMICS. 5:1914-1927
Our current approach focused on the identification of potential early protein biomarker signatures which are indicative of the carcinogenic processes in rats exposed to 20 mg/kg of the liver carcinogen N-nitrosomorpholine (NNM). Treated liver was inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9df6007701497867c782acb5ca8198
https://doi.org/10.1002/pmic.200401067
https://doi.org/10.1002/pmic.200401067
Autor:
U. Gundert-Remy, M. Kröger, A. Oberemm, Jürgen Hellmann, Matthias Glückmann, H.-B. Richter-Reichhelm, Eberhard Krause, Annette Kopp-Schneider, K. Kalenberg, K. Fella, Carina Ittrich, P.-J. Kramer, A. Herzig
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 369:131-135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3250a240135266aebdb155b94e3665c
https://doi.org/10.1007/s00210-004-0912-y
https://doi.org/10.1007/s00210-004-0912-y
Autor:
Kevin Keane, Christine Ruehl-Fehlert, Birgit Kittel, Sabine Halm, Anke Heuser, Axel Bube, Jürgen Hellmann, Gerd Morawietz
Publikováno v:
Experimental and Toxicologic Pathology. 55:433-449
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adf03f8f74bec34718ff2a62a6dbc3d4
https://doi.org/10.1078/0940-2993-00350
https://doi.org/10.1078/0940-2993-00350
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 81:390
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e33fbeaee183a3352a83b283a1fead8d
https://doi.org/10.1016/j.vascn.2016.02.179
https://doi.org/10.1016/j.vascn.2016.02.179
Autor:
Annette Kopp-Schneider, G. Scholz, Eberhard Krause, E. Kiss, Peter Bannasch, Carina Ittrich, K. Seemann, M. Kröger, Hans-Jürgen Ahr, Marc Weimer, Axel Oberemm, Jürgen Hellmann, Ursula Gundert-Remy, Heidrun Ellinger-Ziegelbauer, Matthias Glückmann, H.-B. Richter-Reichhelm, P.-J. Kramer
Publikováno v:
Toxicology and applied pharmacology. 241(2)
A common animal model of chemical hepatocarcinogenesis was used to examine the utility of transcriptomic and proteomic data to identify early biomarkers related to chemically induced carcinogenesis. N-nitrosomorpholine, a frequently used genotoxic mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31dcba02984c20fee6e98aafb5346d9d
https://pubmed.ncbi.nlm.nih.gov/19716841
https://pubmed.ncbi.nlm.nih.gov/19716841
Autor:
Gerd, Morawietz, Christine, Ruehl-Fehlert, Birgit, Kittel, Axel, Bube, Kevin, Keane, Sabine, Halm, Anke, Heuser, Jürgen, Hellmann
Publikováno v:
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 55(6)
This is the third part of a series of three articles on trimming instructions of rat and mouse protocol organs and tissues in regulatory type toxicity studies, covering the urinary, nervous, musculoskeletal, cardiovascular, and lymphoreticular system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e72b410500b6135666de8c1700c84a64
https://pubmed.ncbi.nlm.nih.gov/15384249
https://pubmed.ncbi.nlm.nih.gov/15384249
Autor:
Michaela, Kröger, Jürgen, Hellmann, Luca, Toldo, Matthias, Glückmann, Bettina, von Eiff, Kerstin, Fella, Peter-Jürgen, Kramer
Publikováno v:
ALTEX. 21
The rapid development of molecular toxicology is providing innovative approaches to an improved investigation and recognition of toxic substances. Proteome analysis offers, with 2DE/MS (two-dimensional gel electrophoresis and mass spectrometry) and S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::472a4aad32816b1cc638e53bd9c90680
https://pubmed.ncbi.nlm.nih.gov/15057406
https://pubmed.ncbi.nlm.nih.gov/15057406