Zobrazeno 1 - 10
of 327
pro vyhledávání: '"Jürgen, Götz"'
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-5 (2024)
Abstract Tau is a microtubule-associated protein that is regulated by post-translational modifications. The most studied of these modifications is phosphorylation, which affects Tau’s aggregation and loss- and gain-of-functions, including the inter
Externí odkaz:
https://doaj.org/article/5740702fac0f4501aea30acf98b8a9d9
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102418- (2023)
Summary: Bioorthogonal labeling and click chemistry techniques allow the detailed examination of cellular physiology through tagging and visualizing newly synthesized proteins. Here, we describe three methods applying bioorthogonal non-canonical amin
Externí odkaz:
https://doaj.org/article/ee6d62337e0e4c569509813152def57a
Publikováno v:
Molecular Brain, Vol 16, Iss 1, Pp 1-5 (2023)
Abstract Synaptic degeneration is a precursor of synaptic and neuronal loss in neurodegenerative diseases such as Alzheimer’s disease (AD) and frontotemporal dementia with tau pathology (FTD-tau), a group of primary tauopathies. A critical role in
Externí odkaz:
https://doaj.org/article/373093bdf15547e2980ab7ec67eb4114
Autor:
Gerhard Leinenga, Liviu‐Gabriel Bodea, Jan Schröder, Giuzhi Sun, Yichen Zhou, Jae Song, Alexandra Grubman, Jose M. Polo, Jürgen Götz
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 1, Pp n/a-n/a (2023)
Abstract Transcranial scanning ultrasound combined with intravenously injected microbubbles (SUS+MB) has been shown to transiently open the blood–brain barrier and reduce the amyloid‐β (Aβ) pathology in the APP23 mouse model of Alzheimer's dise
Externí odkaz:
https://doaj.org/article/4eada074200a42d6b53a82eee438c48a
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-14 (2021)
Abstract The synthesis of new proteins is a fundamental aspect of cellular life and is required for many neurological processes, including the formation, updating and extinction of long-term memories. Protein synthesis is impaired in neurodegenerativ
Externí odkaz:
https://doaj.org/article/4127815f43ac4aa0bd01fb124c002f62
Autor:
Mark T. Milner, Grace MEP. Lawrence, Caroline L. Holley, Liviu-Gabriel Bodea, Jürgen Götz, Sabrina S. Burgener, Kate Schroder
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101295- (2022)
Summary: Microglia and astrocytes are implicated in aging and age-related diseases. Here, we present a protocol to isolate and culture these glia cells from the murine brain. The protocol consists of two parts: magnetic sorting of adult microglia and
Externí odkaz:
https://doaj.org/article/873a1670daff428f9d2deca6f621e12f
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-14 (2021)
Abstract Background Aducanumab is an anti-amyloid-β (Aβ) antibody that achieved reduced amyloid pathology in Alzheimer’s disease (AD) trials; however, it is controversial whether it also improved cognition, which has been suggested would require
Externí odkaz:
https://doaj.org/article/23b445421c0247a5b2997387a4595865
Autor:
Rinie Bajracharya, David Brici, Liviu-Gabriel Bodea, Phillip W. Janowicz, Jürgen Götz, Rebecca M. Nisbet
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-13 (2021)
Abstract One of the main pathological hallmarks of Alzheimer’s disease (AD) is the intraneuronal accumulation of hyperphosphorylated tau. Passive immunotherapy is a promising strategy for the treatment of AD and there are currently a number of tau-
Externí odkaz:
https://doaj.org/article/4286f9b494104bcda22c0c56c8102b26
Publikováno v:
Brain Sciences, Vol 12, Iss 6, p 775 (2022)
Ultrasound is routinely used for a wide range of diagnostic imaging applications. However, given that ultrasound can operate over a wide range of parameters that can all be modulated, its applicability extends far beyond the bioimaging field. In fact
Externí odkaz:
https://doaj.org/article/21ae65720b9d45c9b29b209d70a29125
Autor:
Pranesh Padmanabhan, Jürgen Götz
Publikováno v:
Nature Aging. 3:481-493
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c824661d4b80c28536d1709574f9ea5
https://doi.org/10.1038/s43587-023-00402-4
https://doi.org/10.1038/s43587-023-00402-4