Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Jürgen, Einsiedel"'
Autor:
Kim-Viktoria Bolik, Jan Hellmann, Simone Maschauer, Eduard Neu, Jürgen Einsiedel, Patrick Riss, Nora Vogg, Jörg König, Martin F. Fromm, Harald Hübner, Peter Gmeiner, Olaf Prante
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Background The orexin receptor (OXR) plays a role in drug addiction and is aberrantly expressed in colorectal tumors. Subtype-selective OXR PET ligands suitable for in vivo use have not yet been reported. This work reports the development of
Externí odkaz:
https://doaj.org/article/7220bee43e0941a9b4e53a8f1aa38dba
Autor:
Simone Maschauer, Tina Ruckdeschel, Philipp Tripal, Roland Haubner, Jürgen Einsiedel, Harald Hübner, Peter Gmeiner, Torsten Kuwert, Olaf Prante
Publikováno v:
Pharmaceuticals, Vol 7, Iss 4, Pp 464-481 (2014)
The neurotensin receptor (NTS1) has emerged as an interesting target for molecular imaging and radiotherapy of NTS-positive tumors due to the overexpression in a range of tumors. The aim of this study was to develop a 177Lu-labeled NTS1 radioligand,
Externí odkaz:
https://doaj.org/article/dd0a545755b14bdda5acc42681b1c929
Autor:
Simone Maschauer, Jürgen Einsiedel, Dominik Reich, Harald Hübner, Peter Gmeiner, Hans-Jürgen Wester, Olaf Prante, Johannes Notni
Publikováno v:
Pharmaceuticals, Vol 10, Iss 1, p 29 (2017)
Neurotensin receptor 1 (NTS1) is overexpressed on a variety of cancer entities; for example, prostate cancer, ductal pancreatic adenocarcinoma, and breast cancer. Therefore, it represents an interesting target for the diagnosis of these cancers types
Externí odkaz:
https://doaj.org/article/3988324a3d91412a9764abaf83612d08
Publikováno v:
Addiction biologyREFERENCES. 26(5)
Neurotensin is an endogenous neuropeptide that acts as a potent modulator of ventral tegmental area (VTA) neurotransmission. The present study was aimed at determining VTA cell population and neurotensin receptor subtype responsible for the initiatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f50cca22b232c38e6ce7d99c471d6e48
https://pubmed.ncbi.nlm.nih.gov/33491227
https://pubmed.ncbi.nlm.nih.gov/33491227
Publikováno v:
Bioorganic & Medicinal Chemistry. 61:116720
A broadly applicable synthesis of peptides incorporating mixed disulfides between cysteine and homocysteine and cysteamine was developed. The method was established using pharmacologically relevant G protein-coupled receptor (GPCR) ligands including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12eedde6af376046313c74dcb66f0235
https://doi.org/10.1016/j.bmc.2022.116720
https://doi.org/10.1016/j.bmc.2022.116720
Autor:
Harald Hübner, Manuel Bause, Peter Gmeiner, Jürgen Einsiedel, Michael Dobmeier, Daniel Lachmann, Burkhard König, Nadja A. Simeth, Ralf C. Kling
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:350-359
Stimulation of the NTS2 neurotensin receptor causes antipsychotic effects and leads to a promotion of the μ-opioid-independent antinociception, which is important in the modulation of tonic pain sensitivity. We report the synthesis and properties of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377ed5f81fa1fc5a215df12ab926b2e6
https://doi.org/10.1016/j.bmc.2016.10.039
https://doi.org/10.1016/j.bmc.2016.10.039
Publikováno v:
Journal of Molecular Modeling. 25
Crystal structures of neurotensin receptor subtype 1 (NTS1) allowed us to visualize the binding mode of the endogenous peptide hormone neurotensin and its pharmacologically active C-terminal fragment NT(8-13) within the orthosteric binding pocket of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d438b970368f0f4d02cd82d4dd7af0
https://doi.org/10.1007/s00894-019-4064-x
https://doi.org/10.1007/s00894-019-4064-x
Publikováno v:
Journal of Medicinal Chemistry. 59:6480-6492
The neurotensin (NT) receptor-1 (NTS1) is overexpressed in a variety of carcinomas and is therefore an interesting target for imaging with positron emission tomography (PET). The aim of this study was the development of new NT derivatives based on th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7017089e1d7854b54096421a1a467a6d
https://doi.org/10.1021/acs.jmedchem.6b00675
https://doi.org/10.1021/acs.jmedchem.6b00675
Autor:
Ralf Palmisano, Mette M. Rosenkilde, Regine Brox, Olav Larsen, Lampros Milanos, Theresa Frank, Jürgen Einsiedel, Gašper Poklukar, Maximilian Dürr, Nuska Tschammer, Reiner Waibel, Ivana Ivanović-Burmazović, Gertrud Malene Hjortø
Publikováno v:
Journal of Medicinal Chemistry. 59:2222-2243
In this work we report a design, synthesis, and detailed functional characterization of unique strongly biased allosteric agonists of CXCR3 that contain tetrahydroisoquinoline carboxamide cores. Compound 11 (FAUC1036) is the first strongly biased all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72de76ac677805829960228e9a484f6
https://doi.org/10.1021/acs.jmedchem.5b01965
https://doi.org/10.1021/acs.jmedchem.5b01965
Autor:
Peter Gmeiner, Philipp Tripal, Simone Maschauer, Harald Hübner, Cornelia Greff, Jürgen Einsiedel, Olaf Prante, Julian J. Ott
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:4026-4033
The neurotensin receptor 2 (NTS2) is an attractive target for cancer imaging, as it is overexpressed in a variety of tumor types including prostate, pancreas and breast carcinoma. The aim of this study was the development of the first NTS2 subtype se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f9bc2ebc8e137aa2add09f410b3de3
https://doi.org/10.1016/j.bmc.2015.01.053
https://doi.org/10.1016/j.bmc.2015.01.053