Zobrazeno 1 - 10
of 233
pro vyhledávání: '"Jürgen, Borlak"'
Autor:
Jürgen Borlak, Yari Ciribilli, Alessandra Bisio, Saravanakumar Selvaraj, Alberto Inga, Jung-Hwa Oh, Reinhard Spanel
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-34 (2024)
Abstract Background Doxorubicin is an important anticancer drug, however, elicits dose-dependently cardiomyopathy. Given its mode of action, i.e. topoisomerase inhibition and DNA damage, we investigated genetic events associated with cardiomyopathy a
Externí odkaz:
https://doaj.org/article/e2adbab09e374e0287dee8c39f980553
Autor:
Xiaoyan Lu, Lingqi Yu, Jie Zheng, Anyao Li, Junying Li, He Lou, Wentao Zhang, Hui Guo, Yuzhen Wang, Xuemei Li, Yue Gao, Xiaohui Fan, Jürgen Borlak
Publikováno v:
MedComm, Vol 5, Iss 9, Pp n/a-n/a (2024)
Abstract Understanding the endogenous mechanism of adaptive response to drug‐induced liver injury (arDILI) may discover innovative strategies to manage DILI. To gain mechanistic insight into arDILI, we investigated exosomal miRNAs in the adaptive r
Externí odkaz:
https://doaj.org/article/82e3f1c2ac184f829c77dbd4b41f8a69
Autor:
Meng He, Jürgen Borlak
Publikováno v:
Immunity & Ageing, Vol 20, Iss 1, Pp 1-47 (2023)
Abstract Background The aging lung is a complex process and influenced by various stressors, especially airborne pathogens and xenobiotics. Additionally, a lifetime exposure to antigens results in structural and functional changes of the lung; yet an
Externí odkaz:
https://doaj.org/article/06cdf92b501d4e59a154ac4dbf2f13ce
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-33 (2023)
Abstract Background Targeting the epigenome of cancerous diseases represents an innovative approach, and the DNA methylation inhibitor decitabine is recommended for the treatment of hematological malignancies. Although epigenetic alterations are also
Externí odkaz:
https://doaj.org/article/77be43e9779a4f618ea8b92f09775757
Autor:
Shen Zhong, Jürgen Borlak
Publikováno v:
EBioMedicine, Vol 95, Iss , Pp 104763- (2023)
Summary: Background: Women are at greater risk of developing non-small cell lung cancer (NSCLC), yet the underlying causes remain unclear. Methods: We performed whole genome scans in lung tumours of cRaf transgenic mice and identified miRNA, transcri
Externí odkaz:
https://doaj.org/article/25513a74c75646a8b6457153dbd2b263
Autor:
Meng He, Jürgen Borlak
Publikováno v:
Immunity & Ageing, Vol 21, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/da2ac7adce3049aa9bf4570c62dd2fe5
Autor:
Mahmoud M. Elalfy, Jürgen Borlak
Publikováno v:
SciMedicine Journal, Vol 3, Iss 2, Pp 138-152 (2021)
Objectives: To identify the regulated genes or the spliced genes of diethylnitorsamine (NDEA) in ATT-myc mice versus control group. Methods: We analysed the 9 hybridizations on the MouseExon10ST array of NDEA treatments and control non- transgenic by
Externí odkaz:
https://doaj.org/article/a749417bd1ae44d795e2ac52e2672ed0
Autor:
Jürgen Borlak, Hans-Christoph Diener, Johanna Kleeberg-Hartmann, Karl Messlinger, Stephen Silberstein
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Petasins are the pharmacologically active ingredients of butterbur and of therapeutic benefit in the treatment of migraine and tension headaches. Here, we summarize the pharmacology, safety and clinical efficacy of butterbur in the prevention of migr
Externí odkaz:
https://doaj.org/article/500d65cdef8f4d2daba8fbccbcd5f335
Publikováno v:
BMC Medical Genomics, Vol 11, Iss 1, Pp 1-20 (2018)
Abstract Background Non-alcoholic fatty liver disease (NAFLD) is a major health burden in need for new medication. To identify potential drug targets a genomic study was performed in lipid-laden primary human hepatocyte (PHH) and human hepatoma cell
Externí odkaz:
https://doaj.org/article/73c7d279cc8540e5b1764f7945903e77
Autor:
Xiaoyan Lu, Lingqi Yu, Jie Zheng, Anyao Li, Junying Li, He Lou, Wentao Zhang, Hui Guo, Yuzhen Wang, Xuemei Li, Yue Gao, Xiaohui Fan, Jürgen Borlak
Background Adaptive response to drug-induced liver injury (arDILI) reflects the critical role of restorative tissue repair, and understanding the endogenous mechanism may discover innovative strategies to manage DILI. Methods To gain mechanistic insi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd44073fe28be083bce187f8ad18975b
https://doi.org/10.21203/rs.3.rs-2920061/v1
https://doi.org/10.21203/rs.3.rs-2920061/v1
