Zobrazeno 1 - 10
of 279
pro vyhledávání: '"Jürgen, Bernhagen"'
Autor:
Sebastian Huth, Laura Huth, Ruth Heise, Yvonne Marquardt, Linda Lopopolo, Marta Piecychna, Peter Boor, Günter Fingerle-Rowson, Aphrodite Kapurniotu, Amir S. Yazdi, Richard Bucala, Jürgen Bernhagen, Jens Malte Baron
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Non-melanoma skin cancer (NMSC) is the most common cancer in Caucasians worldwide. We investigated the pathophysiological role of MIF and its homolog D-DT in UVB- and chemically induced NMSC using Mif −/− , D-dt −/− and Mif −/− /
Externí odkaz:
https://doaj.org/article/8ebd7b8989b44e6894a89cef5e2ef620
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/2bd769f1ff8f479a84aa2c6fa26f8c3b
Autor:
Karin Taş, Beatrice Dalla Volta, Christina Lindner, Omar El Bounkari, Kathleen Hille, Yuan Tian, Xènia Puig-Bosch, Markus Ballmann, Simon Hornung, Martin Ortner, Sophia Prem, Laura Meier, Gerhard Rammes, Martin Haslbeck, Christian Weber, Remco T. A. Megens, Jürgen Bernhagen, Aphrodite Kapurniotu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Amyloid self-assembly is linked to type 2 diabetes and Alzheimer’s disease. Here the authors designed constrained peptides which are nanomolar amyloid inhibitors of the key polypeptides IAPP and Aβ42 and act via supramolecular nanofiber co-assembl
Externí odkaz:
https://doaj.org/article/3b23585f88cb4b29866249912e9885cc
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 2 (2023)
Macrophage migration inhibitory factor (MIF) and its homolog, D-dopachrome tautomerase (D-DT), are cytokines that play critical roles in the immune response to various infectious diseases. This review provides an overview of the complex involvement o
Externí odkaz:
https://doaj.org/article/436c2e376060469aa778085cf7698568
Autor:
Mauro Vasella, Stefan Wolf, Eamon C. Francis, Gerrit Grieb, Pablo Pfister, Gregory Reid, Jürgen Bernhagen, Nicole Lindenblatt, Epameinondas Gousopoulos, Bong-Sung Kim
Publikováno v:
Metabolites, Vol 13, Iss 10, p 1105 (2023)
Lipedema is a chronic disorder that mainly affects women. It is often misdiagnosed, and its etiology remains unknown. Recent research indicates an accumulation of macrophages and a shift in macrophage polarization in lipedema. One known protein super
Externí odkaz:
https://doaj.org/article/a3921d121828402e8a01cacc10c569e4
Autor:
Yaw Asare, Margarita Shnipova, Luka Živković, Christina Schlegl, Federica Tosato, Arailym Aronova, Markus Brandhofer, Laura Strohm, Nathalie Beaufort, Rainer Malik, Christian Weber, Jürgen Bernhagen, Martin Dichgans
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/f97a6c6e18084fe7ab7ef04989a79b44
Autor:
Simon Ebert, Lan Zang, Noor Ismail, Michael Otabil, Adrian Fröhlich, Virginia Egea, Susann Ács, Mikkel Hoeberg, Marie-Luise Berres, Christian Weber, José M. A. Moreira, Christian Ries, Jürgen Bernhagen, Omar El Bounkari
Publikováno v:
Cells, Vol 12, Iss 14, p 1899 (2023)
Tissue inhibitor of metalloproteinases-1 (TIMP-1), an important regulator of matrix metalloproteinases (MMPs), has recently been shown to interact with CD74, a receptor for macrophage migration inhibitory factor (MIF). However, the biological effects
Externí odkaz:
https://doaj.org/article/7f4b293c46944de99806238b9e505219
Autor:
Stephanie Dobersch, Karla Rubio, Indrabahadur Singh, Stefan Günther, Johannes Graumann, Julio Cordero, Rafael Castillo-Negrete, Minh Bao Huynh, Aditi Mehta, Peter Braubach, Hector Cabrera-Fuentes, Jürgen Bernhagen, Cho-Ming Chao, Saverio Bellusci, Andreas Günther, Klaus T. Preissner, Sita Kugel, Gergana Dobreva, Malgorzata Wygrecka, Thomas Braun, Dulce Papy-Garcia, Guillermo Barreto
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
The order of DNA methylation and histone modifications during transcription remained unclear. Here the authors show that HMGA2 induces DNA nicks at TGFB1-responsive genes, promoting nucleosome incorporation containing γ-H2AX, which is required for r
Externí odkaz:
https://doaj.org/article/c551a764a6c040d58f3cbdc0affd583b
Autor:
Christos Kontos, Omar El Bounkari, Christine Krammer, Dzmitry Sinitski, Kathleen Hille, Chunfang Zan, Guangyao Yan, Sijia Wang, Ying Gao, Markus Brandhofer, Remco T. A. Megens, Adrian Hoffmann, Jessica Pauli, Yaw Asare, Simona Gerra, Priscila Bourilhon, Lin Leng, Hans-Henning Eckstein, Wolfgang E. Kempf, Jaroslav Pelisek, Ozgun Gokce, Lars Maegdefessel, Richard Bucala, Martin Dichgans, Christian Weber, Aphrodite Kapurniotu, Jürgen Bernhagen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
The development of specific anti-cytokine/chemokine therapeutic strategies for atherosclerotic disease is challenging. Here, the authors have designed a peptide-based ectodomain mimic of the chemokine receptor CXCR4 that selectively targets MIF but n
Externí odkaz:
https://doaj.org/article/8d9c94b2adec4a06a56a819e022710e7
Autor:
Christian Liedtke, Yulia A. Nevzorova, Tom Luedde, Henning Zimmermann, Daniela Kroy, Pavel Strnad, Marie-Luise Berres, Jürgen Bernhagen, Frank Tacke, Jacob Nattermann, Ulrich Spengler, Tilman Sauerbruch, Alexander Wree, Zeinab Abdullah, René H. Tolba, Jonel Trebicka, Twan Lammers, Christian Trautwein, Ralf Weiskirchen
Publikováno v:
Frontiers in Medicine, Vol 8 (2022)
The Transregional Collaborative Research Center “Organ Fibrosis: From Mechanisms of Injury to Modulation of Disease” (referred to as SFB/TRR57) was funded for 13 years (2009–2021) by the German Research Council (DFG). This consortium was hosted
Externí odkaz:
https://doaj.org/article/854f4678a7ef45078def2dc8a24e231a