Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Jürgen, Behrens"'
Autor:
Cezanne Miete, Gonzalo P. Solis, Alexey Koval, Martina Brückner, Vladimir L. Katanaev, Jürgen Behrens, Dominic B. Bernkopf
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Wnt/β-catenin signalling is frequently hyperactivated in colorectal carcinoma (CRC). Here the authors show that Gαi2 inhibits this signalling pathway by promoting the condensation of conductin/axin2 and β-catenin degradation, and consequently supp
Externí odkaz:
https://doaj.org/article/022e76d7e8894ba1aba6ff13a89518c1
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Polymerization of axin proteins is essential to suppress Wnt/β-catenin signaling. Here, the authors identify an aggregation site in the conductin/axin2 RGS domain that prevents its polymerization and show that a short peptide masking this aggregon p
Externí odkaz:
https://doaj.org/article/7ee0b10cbec64fbaa950ca92c1c59c9c
Autor:
Thomas Brabletz, Jürgen Behrens, Thomas Kirchner, Andreas Eger, Dennis Strand, Andreas Jung, Falk Hlubek, Aneesa Sultan, Katja Bauer, Arno Dimmler, Mandy Wahlbuhl, Otto Schmalhofer, Simone Spaderna
Supplementary Figure Legends 1-3 from The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe0f08a8d76a7c0c3f5f7e0b8e2eabb
https://doi.org/10.1158/0008-5472.22374965
https://doi.org/10.1158/0008-5472.22374965
Autor:
Thomas Brabletz, Jürgen Behrens, Thomas Kirchner, Andreas Eger, Dennis Strand, Andreas Jung, Falk Hlubek, Aneesa Sultan, Katja Bauer, Arno Dimmler, Mandy Wahlbuhl, Otto Schmalhofer, Simone Spaderna
Supplementary Figure 3 from The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3fd466c931cd86253d67098ab9f654
https://doi.org/10.1158/0008-5472.22374968
https://doi.org/10.1158/0008-5472.22374968
Autor:
Thomas Brabletz, Jürgen Behrens, Thomas Kirchner, Andreas Eger, Dennis Strand, Andreas Jung, Falk Hlubek, Aneesa Sultan, Katja Bauer, Arno Dimmler, Mandy Wahlbuhl, Otto Schmalhofer, Simone Spaderna
Supplementary Figure 1 from The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73041f98c82bb06a9c148755c8bc1b74
https://doi.org/10.1158/0008-5472.22374974.v1
https://doi.org/10.1158/0008-5472.22374974.v1
Autor:
Dominic B. Bernkopf, Jürgen Behrens
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 3 (2018)
Cellular abundance of mitochondria is dynamically regulated. We could recently show that dysfunctional mitochondria release the phosphatase PGAM family member 5 (PGAM5) into the cytosol, where it interacts with the Wnt signaling-component AXIN1 and d
Externí odkaz:
https://doaj.org/article/6d90ac6abdde44b49e0fe80e937e09ec
Autor:
Ingrid Wacker, Jürgen Behrens
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111276 (2014)
Activin B belongs to the TGFβ family of growth factors and is upregulated in clear cell renal cell carcinoma cells by hypoxia inducible factors. Expression of Activin B is required for tumor growth in vivo and tumor cell invasion in vitro. Here we s
Externí odkaz:
https://doaj.org/article/7018382405974ff0b518ff977614ef68
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94413 (2014)
Wnt signalling is prevented by the proteosomal degradation of β-catenin, which occurs in a destruction complex containing adenomatous polyposis coli (APC), APC-like (APCL), Axin and Axin2. Truncating mutations of the APC gene result in the constitut
Externí odkaz:
https://doaj.org/article/35c2d57e45854da5a8b410e28d3ca138
Autor:
Cezanne Miete, Gonzalo P. Solis, Alexey Koval, Martina Brückner, Vladimir L. Katanaev, Jürgen Behrens, Dominic B. Bernkopf
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Nature communications, Vol. 13, No 1 (2022) P. 674
Nature communications, Vol. 13, No 1 (2022) P. 674
Conductin/axin2 is a scaffold protein negatively regulating the pro-proliferative Wnt/β-catenin signaling pathway. Accumulation of scaffold proteins in condensates frequently increases their activity, but whether condensation contributes to Wnt path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe885a2c8672e90aca452bf1e54608d6
https://pubmed.ncbi.nlm.nih.gov/35115535
https://pubmed.ncbi.nlm.nih.gov/35115535