Zobrazeno 1 - 10
of 248
pro vyhledávání: '"Jürg Gertsch"'
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-23 (2024)
Abstract Multiple sclerosis (MS) is a complex chronic neuroinflammatory disease characterized by demyelination leading to neuronal dysfunction and neurodegeneration manifested by various neurological impairments. The endocannabinoid system (ECS) is a
Externí odkaz:
https://doaj.org/article/70ef30f046d84a22a347e1e78698a250
Autor:
Stephan Hirschi, Thomas Lemmin, Nooraldeen Ayoub, David Kalbermatter, Daniele Pellegata, Zöhre Ucurum, Jürg Gertsch, Dimitrios Fotiadis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Microbial ion-pumping rhodopsins (MRs) are extensively studied retinal-binding membrane proteins. However, their biogenesis, including oligomerisation and retinal incorporation, remains poorly understood. The bacterial green-light absorbing
Externí odkaz:
https://doaj.org/article/a108a1ee9b9d4375998fcce708237c39
Autor:
Daniel Bátora, Ágnes Dienes-Nagy, Liming Zeng, Christian E. Gerber, Jérôme P. Fischer, Martin Lochner, Jürg Gertsch
Publikováno v:
Food Chemistry: X, Vol 23, Iss , Pp 101592- (2024)
Tannins are chemically diverse polyphenols in plant-derived products that not only show diverse biological activities but also play a crucial role in determining the sensory attributes of food and beverages. Therefore, their accurate and cost-effecti
Externí odkaz:
https://doaj.org/article/d5fcab5656db494b9c7ac8e066ac4186
Autor:
Liad Hinden, Majdoleen Ahmad, Sharleen Hamad, Alina Nemirovski, Gergő Szanda, Sandra Glasmacher, Aviram Kogot-Levin, Rinat Abramovitch, Bernard Thorens, Jürg Gertsch, Gil Leibowitz, Joseph Tam
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Renal proximal tubules modulate whole-body homeostasis by sensing various nutrients. Here the authors describe the existence and importance of a unique CB1/mTORC1/GLUT2 signaling axis in regulating nutrient homeostasis in healthy and diseased kidney.
Externí odkaz:
https://doaj.org/article/fa78e76598394da191ce9a6dc515b56c
Autor:
Joanna Kowalczyk, Barbara Budzyńska, Łukasz Kurach, Daniele Pellegata, Nesrine S. El Sayed, Jürg Gertsch, Krystyna Skalicka-Woźniak
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Scoparone (6,7-dimethoxycoumarin) is a simple coumarin from botanical drugs of Artemisia species used in Traditional Chinese Medicine and Génépi liquor. However, its bioavailability to the brain and potential central effects remain unexplo
Externí odkaz:
https://doaj.org/article/94186d10ee4b46908e20e819a998a71c
Autor:
Jean-Marc Jeckelmann, Jonas Zaugg, Veronika Morozova, Jennifer Müller, Satish Kantipudi, Mariana Schroeder, Julien Graff, Christiane Albrecht, Karl-Heinz Altmann, Jürg Gertsch, Dimitrios Fotiadis
Publikováno v:
CHIMIA, Vol 76, Iss 12 (2022)
Amino acids are essential components of all living cells serving as building blocks of proteins, as energy source, and as precursors of metabolites and signaling molecules. Amino acid transporters are membrane proteins that mediate the transfer of am
Externí odkaz:
https://doaj.org/article/eced44bd17e44a3f86e4513d38f6789c
Autor:
Adrianna Skiba, Daniele Pellegata, Veronika Morozova, Ewelina Kozioł, Barbara Budzyńska, Simon Ming-Yuen Lee, Jürg Gertsch, Krystyna Skalicka-Woźniak
Publikováno v:
Cells, Vol 12, Iss 11, p 1540 (2023)
Zebrafish (Danio rerio) assays provide a versatile pharmacological platform to test compounds on a wide range of behaviors in a whole organism. A major challenge lies in the lack of knowledge about the bioavailability and pharmacodynamic effects of b
Externí odkaz:
https://doaj.org/article/54c9053e75814ac5bd2bfd79806650c1
Autor:
Renhong Yan, Yaning Li, Jennifer Müller, Yuanyuan Zhang, Simon Singer, Lu Xia, Xinyue Zhong, Jürg Gertsch, Karl-Heinz Altmann, Qiang Zhou
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-8 (2021)
Abstract LAT1 (SLC7A5) is one of the representative light chain proteins of heteromeric amino acid transporters, forming a heterodimer with its heavy chain partner 4F2hc (SLC3A2). LAT1 is overexpressed in many types of tumors and mediates the transfe
Externí odkaz:
https://doaj.org/article/5519880d1f784d94a4c45a0208921b2a
Autor:
Andrea Salm, Jürg Gertsch
Publikováno v:
Parasites & Vectors, Vol 12, Iss 1, Pp 1-19 (2019)
Abstract Background Chagas disease remains a major public health risk in Bolivia, particularly among rural indigenous communities. Here we studied the cultural perception of the triatomine vectors and Chagas disease among selected rural and urban eth
Externí odkaz:
https://doaj.org/article/8d821edcc2574282873f61431add7237
Autor:
Silvia Marino, Daniëlle de Ridder, Ryan T. Bishop, Nathalie Renema, Marco Ponzetti, Antonia Sophocleous, Mattia Capulli, Abdullah Aljeffery, Giovana Carrasco, Marianela Dalghi Gens, Asim Khogeer, Stuart H. Ralston, Jürg Gertsch, Francois Lamoureux, Dominique Heymann, Nadia Rucci, Aymen I. Idris
Publikováno v:
EBioMedicine, Vol 44, Iss , Pp 452-466 (2019)
Background: Cancer-associated bone disease is a serious complication in bone sarcomas and metastatic carcinomas of breast and prostate origin. Monoacylglycerol lipase (MAGL) is an enzyme of the endocannabinoid system, and is responsible for the degra
Externí odkaz:
https://doaj.org/article/ebe9f63efbf641769fb4ae082d43376f