Zobrazeno 1 - 10
of 244
pro vyhledávání: '"Jürg, Bähler"'
Autor:
Matthias Weith, Jan Großbach, Mathieu Clement‐Ziza, Ludovic Gillet, María Rodríguez‐López, Samuel Marguerat, Christopher T Workman, Paola Picotti, Jürg Bähler, Ruedi Aebersold, Andreas Beyer
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 8, Pp 1-21 (2023)
Abstract The complexity of many cellular and organismal traits results from the integration of genetic and environmental factors via molecular networks. Network structure and effect propagation are best understood at the level of functional modules,
Externí odkaz:
https://doaj.org/article/4f972d70022840c5813a7645a1b8d926
Autor:
Carina C. Kern, Shivangi Srivastava, Marina Ezcurra, Kuei Ching Hsiung, Nancy Hui, StJohn Townsend, Dominik Maczik, Bruce Zhang, Victoria Tse, Viktoras Konstantellos, Jürg Bähler, David Gems
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract In post-reproductive C. elegans, destructive somatic biomass repurposing supports production of yolk which, it was recently shown, is vented and can serve as a foodstuff for larval progeny. This is reminiscent of the suicidal reproductive ef
Externí odkaz:
https://doaj.org/article/04171472277441768359127462819334
Autor:
María Rodríguez-López, Nicola Bordin, Jon Lees, Harry Scholes, Shaimaa Hassan, Quentin Saintain, Stephan Kamrad, Christine Orengo, Jürg Bähler
Publikováno v:
eLife, Vol 12 (2023)
Many proteins remain poorly characterized even in well-studied organisms, presenting a bottleneck for research. We applied phenomics and machine-learning approaches with Schizosaccharomyces pombe for broad cues on protein functions. We assayed colony
Externí odkaz:
https://doaj.org/article/1e2e0ac5bcd64e5a95d52821d8b5c76a
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0285576 (2023)
Messenger RNA uridylation is pervasive and conserved among eukaryotes, but the consequences of this modification for mRNA fate are still under debate. Utilising a simple model organism to study uridylation may facilitate efforts to understand the cel
Externí odkaz:
https://doaj.org/article/77a47fd206794dbebe4c70b7a4eb5ce8
Autor:
Jarmila Princová, Clàudia Salat-Canela, Petr Daněk, Anna Marešová, Laura de Cubas, Jürg Bähler, José Ayté, Elena Hidalgo, Martin Převorovský
Publikováno v:
PLoS Genetics, Vol 19, Iss 1, p e1010582 (2023)
Oxidative stress is associated with cardiovascular and neurodegenerative diseases, diabetes, cancer, psychiatric disorders and aging. In order to counteract, eliminate and/or adapt to the sources of stress, cells possess elaborate stress-response mec
Externí odkaz:
https://doaj.org/article/6b3f0849a4714c1bbcf92b9f304769a0
Autor:
Carina C. Kern, StJohn Townsend, Antoine Salzmann, Nigel B. Rendell, Graham W. Taylor, Ruxandra M. Comisel, Lazaros C. Foukas, Jürg Bähler, David Gems
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
It is unclear why C. elegans continues to produce large quantities of yolk after reproduction. Here the authors show that post-reproductive C. elegans mothers vent yolk which supports their offspring’s growth, serving as a form of primitive lactati
Externí odkaz:
https://doaj.org/article/055664668cb24b469c3a15be409762ad
Autor:
Catalina A. Romila, StJohn Townsend, Michal Malecki, Stephan Kamrad, María Rodríguez-López, Olivia Hillson, Cristina Cotobal, Markus Ralser, Jürg Bähler
Publikováno v:
Microbial Cell, Vol 8, Iss 7, Pp 146-160 (2021)
Ageing-related processes are largely conserved, with simple organisms remaining the main platform to discover and dissect new ageing-associated genes. Yeasts provide potent model systems to study cellular ageing owing their amenability to systematic
Externí odkaz:
https://doaj.org/article/792d2d11245640b28c2403ad1eef10fa
Autor:
Christopher J. Minnis, StJohn Townsend, Julia Petschnigg, Elisa Tinelli, Jürg Bähler, Claire Russell, Sara E. Mole
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Juvenile CLN3 disease is a recessively inherited paediatric neurodegenerative disorder, with most patients homozygous for a 1-kb intragenic deletion in CLN3. The btn1 gene is the Schizosaccharomyces pombe orthologue of CLN3. Here, we have ex
Externí odkaz:
https://doaj.org/article/6527e4bac2b54420a484033fbe621105
Autor:
Christopher J. Minnis, StJohn Townsend, Julia Petschnigg, Elisa Tinelli, Jürg Bähler, Claire Russell, Sara E. Mole
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/96da108b24f34e5ca18dd0cb24c426b5
Autor:
Stephan Kamrad, Jan Grossbach, Maria Rodríguez‐López, Michael Mülleder, StJohn Townsend, Valentina Cappelletti, Gorjan Stojanovski, Clara Correia‐Melo, Paola Picotti, Andreas Beyer, Markus Ralser, Jürg Bähler
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 4, Pp 1-19 (2020)
Abstract Cells balance glycolysis with respiration to support their metabolic needs in different environmental or physiological contexts. With abundant glucose, many cells prefer to grow by aerobic glycolysis or fermentation. Using 161 natural isolat
Externí odkaz:
https://doaj.org/article/75c014a6c6ba42eaac2a2c6e6001b4d4