Toxicity of spike fragments SARS-CoV-2 S protein for zebrafish: A tool to study its hazardous for human health?

Autor: Ventura Fernandes BH; Laboratório de Controle Genético e Sanitário, Diretoria Técnica de Apoio ao Ensino e Pesquisa, Faculdade de Medicina da Universidade de São Paulo, Brazil., Feitosa NM; Laboratório Integrado de Biociências Translacionais (LIBT), Instituto de Biodiversidade e Sustentabilidade (NUPEM), Universidade Federal do Rio de Janeiro (UFRJ), Macaé, RJ, Brazil., Barbosa AP; Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil., Bomfim CG; Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil., Garnique AMB; Department of Cell Biology, Institute of Biomedical Sciences, University of São Paulo, Brazil., Rosa IF; Reproductive and Molecular Biology Group, Department of Morphology, Institute of Biosciences, Sao Paulo State University, Botucatu, São Paulo, Brazil., Rodrigues MS; Reproductive and Molecular Biology Group, Department of Morphology, Institute of Biosciences, Sao Paulo State University, Botucatu, São Paulo, Brazil., Doretto LB; Reproductive and Molecular Biology Group, Department of Morphology, Institute of Biosciences, Sao Paulo State University, Botucatu, São Paulo, Brazil., Costa DF; Reproductive and Molecular Biology Group, Department of Morphology, Institute of Biosciences, Sao Paulo State University, Botucatu, São Paulo, Brazil., Camargo-Dos-Santos B; Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, São Paulo State University, SP, Brazil., Franco GA; Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, São Paulo State University, SP, Brazil., Neto JF; Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, São Paulo State University, SP, Brazil., Lunardi JS; Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, São Paulo State University, SP, Brazil., Bellot MS; Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, São Paulo State University, SP, Brazil., Alves NPC; Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, São Paulo State University, SP, Brazil., Costa CC; Department of Preventive Veterinary Medicine, São Paulo State University (UNESP), Jaboticabal, Brazil., Aracati MF; Department of Preventive Veterinary Medicine, São Paulo State University (UNESP), Jaboticabal, Brazil., Rodrigues LF; Department of Preventive Veterinary Medicine, São Paulo State University (UNESP), Jaboticabal, Brazil., Costa CC; Department of Preventive Veterinary Medicine, São Paulo State University (UNESP), Jaboticabal, Brazil., Cirilo RH; Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, São Paulo State University, SP, Brazil., Colagrande RM; Department of Structural and Functional Biology, Institute of Biosciences of Botucatu, São Paulo State University, SP, Brazil., Gomes FIF; Department of Pharmacology, Center of Research in Inflammatory Diseases, Ribeirao Preto Medical School, University of São Paulo, Brazil., Nakajima RT; Reproductive and Molecular Biology Group, Department of Morphology, Institute of Biosciences, Sao Paulo State University, Botucatu, São Paulo, Brazil., Belo MAA; Brasil University, Descalvado, São Paulo, Brazil., Giaquinto PC; Universidade Estadual Paulista Júlio de Mesquita Filho, Instituto de Biociências - Departamento de Fisiologia, São Paulo, Brazil., de Oliveira SL; Universidade Estadual Paulista Júlio de Mesquita Filho, São Paulo, Brazil., Eto SF; Postgraduate Program in Health Sciences, PROCISA, Federal University of Roraima, Brazil., Fernandes DC; Immunochemistry Laboratory, Butantan Institute, São Paulo, Brazil., Manrique WG; Aquaculture Health Research and Extension Group, GRUPESA, Aquaculture Health Laboratory, LABSA, Department of Veterinary Medicine, Federal University of Rondônia, Rolim de Moura campus, Rondônia, Brazil., Conde G; Department of Preventive Veterinary Medicine, São Paulo State University, Jaboticabal, Brazil., Rosales RRC; Department of Cell and Molecular Biology, Ribeirao Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Todeschini I; Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Brazil., Rivero I; Pontifícia Universidade Católica de Minas Gerais, Brazil., Llontop E; Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Brazil., Sgro GG; Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Brazil; Departamento de Ciências Biomoleculares, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil., Oka GU; Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Brazil., Bueno NF; Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Brazil., Ferraris FK; Department of Pharmacology and Toxicology, Oswaldo Cruz Foundation, FIOCRUZ, Rio de Janeiro, Brazil., de Magalhães MTQ; Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., Medeiros RJ; Laboratory of Physiology, INCQS/Fiocruz Zebrafish Facility, Departament of Pharmacology and Toxicology, National Institute for Quality Control in Health, Brasil., Mendonça-Gomes JM; Transplantation Immunobiology Lab, Department of Immunology, Institute of Biomedical Sciences, Universidade de Sao Paulo, Brazil., Junqueira MS; Center for Translational Research in Oncology, Cancer Institute of the State of Sao Paulo, Faculty of Medicine, University of São Paulo, Sao Paulo, Brazil., Conceição K; Laboratory of Peptide Biochemistry, Federal University of São Paulo, Brazil., Pontes LG; Laboratory of Human Immunology, Department Immunology, Institute Biomedical Sciences, University São Paulo, Sao Paulo, Brazil., Condino-Neto A; Laboratory of Human Immunology, Department Immunology, Institute Biomedical Sciences, University São Paulo, Sao Paulo, Brazil., Perez AC; Department of Pharmacology, Universidade Federal de Minas Gerais, Brazil., Barcellos LJG; Graduate Program of Pharmacology, Federal University of Santa Maria, Brazil; Laboratory of Fish Physiology, Graduate Program of Bioexperimentation and of Environmental Sciences, University of Passo Fundo, Brazil., Júnior JDC; Laboratório do Estudo da Interação Químico Biológica e da Reprodução Animal, LIQBRA, Bloco O3,174, Brazil; Departamento de Morfologia Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil., Dorlass EG; Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Brazil., Camara NOS; Transplantation Immunobiology Lab, Department of Immunology, Institute of Biomedical Sciences, Universidade de Sao Paulo, Brazil., Durigon EL; Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil., Cunha FQ; Department of Pharmacology, Center of Research in Inflammatory Diseases, Ribeirao Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Nóbrega RH; Reproductive and Molecular Biology Group, Department of Morphology, Institute of Biosciences, Sao Paulo State University, Botucatu, São Paulo, Brazil., Machado-Santelli GM; Department of Cell Biology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Farah CS; Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Brazil., Veras FP; Center of Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of Sao Paulo, Ribeirão Preto, Sao Paulo, Brazil; Department of Pharmacology, Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, São Paulo, Brazil., Galindo-Villegas J; Faculty of Biosciences and Aquaculture, Nord University, 8049 Bodo, Norway., Costa-Lotufo LV; Department of Pharmacology, Institute of Biomedical Sciences, Universidade de São Paulo, Brazil., Cunha TM; Center of Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of Sao Paulo, Ribeirão Preto, Sao Paulo, Brazil; Department of Pharmacology, Ribeirao Preto Medical School, University of São Paulo, Ribeirao Preto, São Paulo, Brazil., Chammas R; Centro de Investigação Translacional em Oncologia, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo, Brazil., Carvalho LR; Disciplina de Endocrinologia do Departamento de Clinica Medica e Laboratório de Hormônios e Genética Molecular, LIM 42, Brazil., Guzzo CR; Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil., Malafaia G; Biological Research Laboratory, Goiano Federal Institute, Urutaí Campus, Brazil. Electronic address: guilhermeifgoiano@gmail.com., Charlie-Silva I; Department of Pharmacology, Institute of Biomedical Sciences, Universidade de São Paulo, Brazil. Electronic address: charliesilva4@hotmail.com.

Publikováno v: The Science of the total environment [Sci Total Environ] 2022 Mar 20; Vol. 813, pp. 152345. Date of Electronic Publication: 2021 Dec 21.

Anti-inflammatory and immune properties of the peltatoside, isolated from the leaves of Annona crassiflora Mart., in a new experimental model zebrafish.

Autor: Prata MNL; Department of Pharmacology, Federal University of Minas Gerais (UFMG), Brazil., Charlie-Silva I; Department of Pharmacology, Federal University of Minas Gerais (UFMG), Brazil., Gomes JMM; Department of Morphology, Federal University of Minas Gerais (UFMG), Brazil., Barra A; Department of Pharmacology, Federal University of Minas Gerais (UFMG), Brazil., Berg BB; Department of Pharmacology, Federal University of Minas Gerais (UFMG), Brazil., Paiva IR; Department of Pharmacology, Federal University of Minas Gerais (UFMG), Brazil., Melo DC; Department of Zootechnics- Federal University of Minas Gerais (UFMG), Brazil., Klein A; Department of Pharmacology, Federal University of Minas Gerais (UFMG), Brazil., Romero MGMC; Department of Pharmacology, Federal University of Minas Gerais (UFMG), Brazil., Oliveira CC; Department of Pharmacology, Federal University of Minas Gerais (UFMG), Brazil., Pimenta LPS; Department of Chemistry, Federal University of Minas Gerais (UFMG), Brazil., Júnior JDC; Department of Morphology, Federal University of Minas Gerais (UFMG), Brazil., Perez AC; Department of Pharmacology, Federal University of Minas Gerais (UFMG), Brazil. Electronic address: acp@ufmg.br.

Publikováno v: Fish & shellfish immunology [Fish Shellfish Immunol] 2020 Jun; Vol. 101, pp. 234-243. Date of Electronic Publication: 2020 Mar 30.