Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Júlia Aguadé-Gorgorió"'
Autor:
Lena Behrmann, Scott McComb, Júlia Aguadé-Gorgorió, Yun Huang, Mario Hermann, Pawel Pelczar, Adriano Aguzzi, Jean Bourquin, Beat Bornhauser
Publikováno v:
Bio-Protocol, Vol 7, Iss 7 (2017)
CRISPR-Cas9 based knockout strategies are increasingly used to analyze gene function. However, redundancies and overlapping functions in biological signaling pathways can call for generating multi-gene knockout cells, which remains a relatively labor
Externí odkaz:
https://doaj.org/article/1b47fe1a935c45e28f8717171c989e5f
Autor:
Vincenzo Calvanese, Sandra Capellera-Garcia, Feiyang Ma, Iman Fares, Simone Liebscher, Elizabeth S. Ng, Sophia Ekstrand, Júlia Aguadé-Gorgorió, Anastasia Vavilina, Diane Lefaudeux, Brian Nadel, Jacky Y. Li, Yanling Wang, Lydia K. Lee, Reza Ardehali, M. Luisa Iruela-Arispe, Matteo Pellegrini, Ed G. Stanley, Andrew G. Elefanty, Katja Schenke-Layland, Hanna K. A. Mikkola
Publikováno v:
Nature
Nature, vol 604, iss 7906
Nature, vol 604, iss 7906
The ontogeny of human haematopoietic stem cells (HSCs) is poorly defined owing to the inability to identify HSCs as they emerge and mature at different haematopoietic sites1. Here we created a single-cell transcriptome map of human haematopoietic tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9b6be55ed181f136e439364fa423d8
https://pubmed.ncbi.nlm.nih.gov/35418685
https://pubmed.ncbi.nlm.nih.gov/35418685
Autor:
Caterina Mezzatesta, Martin Schrappe, Marketa Zaliova, Arend von Stackelberg, Cornelia Eckert, Yi Chien Tsai, Beat Bornhauser, Anna Guinot, Gunnar Cario, Denis M. Schewe, Luciana Vinti, Blerim Marovca, Franco Locatelli, Martin Stanulla, Jean-Pierre Bourquin, Silvia Jenni, Júlia Aguadé-Gorgorió, Liridon Abduli
Publikováno v:
Blood Cancer Journal
Blood Cancer Journal, Vol 10, Iss 6, Pp 1-11 (2020)
Blood Cancer Journal, Vol 10, Iss 6, Pp 1-11 (2020)
Despite rapid progress in genomic profiling in acute lymphoblastic leukemia (ALL), identification of actionable targets and prediction of response to drugs remains challenging. To identify specific vulnerabilities in ALL, we performed a drug screen u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf59fe2fc1f48e1f62c82e86c28466e
https://pubmed.ncbi.nlm.nih.gov/32591499
https://pubmed.ncbi.nlm.nih.gov/32591499
Autor:
Beat Bornhauser, Scott McComb, Caterina Mezzatesta, Silvia Jenni, Jean-Pierre Bourquin, Maria Pamela Dobay, Anna Guinot, Júlia Aguadé-Gorgorió, Martin Stanulla, Arend von Stackelberg, Liridon Abduli, Martin Schrappe, Gunnar Cario, Blerim Marovca, Cornelia Eckert
Publikováno v:
Blood Adv
Despite major advances in the treatment of patients with acute lymphoblastic leukemia in the last decades, refractory and/or relapsed disease remains a clinical challenge, and relapsed leukemia patients have an exceedingly dismal prognosis. Dysregula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a01b8c95089a4ba74af21b7cd81260d
Autor:
Florian Nigsch, Júlia Aguadé-Gorgorió, J Gräsel, H Méreau, B Schacher Engstler, Beat Bornhauser, Louise Barys, William R. Sellers, J-P Bourquin, Gregory R. Hoffman, C Stork-Fux, Ralph Tiedt, Caroline Dafflon, Francesco Hofmann, Juerg Schwaller, Swann Gaulis, A Proske, Masato Murakami, V J Craig, Moriko Ito
Publikováno v:
Leukemia
Chromosomal rearrangements of the mixed lineage leukemia (MLL/KMT2A) gene leading to oncogenic MLL-fusion proteins occur in ~10% of acute leukemias and are associated with poor clinical outcomes, emphasizing the need for new treatment modalities. Inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e46228ead23212fd3eb0117f0575ce65
https://doi.org/10.1038/leu.2016.327
https://doi.org/10.1038/leu.2016.327
Autor:
G Cario, Júlia Aguadé-Gorgorió, Scott McComb, Martin Schrappe, Martin Stanulla, C Eckert, Beat Bornhauser, Maria Pamela Dobay, Caterina Mezzatesta, A von Stackelberg, J-P Bourquin
Publikováno v:
Klinische Pädiatrie.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50eca068223d2ac30d98f60ed25399cb
https://doi.org/10.1055/s-0037-1602216
https://doi.org/10.1055/s-0037-1602216
Autor:
Beat Bornhauser, Júlia Aguadé-Gorgorió
Publikováno v:
Receptors & Clinical Investigation.
The understanding of cell death mechanisms is crucial for the development and application of novel anti-cancer therapies to avoid or circumvent drug-resistance in refractory malignancies. Impairment of apoptotic cell death plays a major role in thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce989bdc4780141552def45764caa0d3
https://doi.org/10.14800/rci.1440
https://doi.org/10.14800/rci.1440
Autor:
Cornelia Eckert, Jean-Pierre Bourquin, Lena Harder, Martin Stanulla, Gunnar Cario, Beat Bornhauser, Martin Schrappe, Scott McComb, Blerim Marovca, Júlia Aguadé-Gorgorió, Arend von Stackelberg
Publikováno v:
Science Translational Medicine. 8
More precise treatment strategies are urgently needed to decrease toxicity and improve outcomes for treatment-refractory leukemia. We used ex vivo drug response profiling of high-risk, relapsed, or refractory acute lymphoblastic leukemia (ALL) cases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f173ce487b054249d3f06f27645433
https://doi.org/10.1126/scitranslmed.aad2986
https://doi.org/10.1126/scitranslmed.aad2986
Autor:
Júlia Aguadé-Gorgorió, Maria Pamela Dobay, Arend von Stackelberg, Beat Bornhauser, Scott McComb, Caterina Mezzatesta, Jean-Pierre Bourquin, Schrappe Martin, Martin Stanulla, Cornelia Eckert, Gunnar Cario
Publikováno v:
Cancer Research. 77:4321-4321
The identification of molecular determinants that regulate sensitivity to specific agents is essential for the development of new therapeutic approaches in cancer. We have earlier shown that a subset of refractory acute lymphoblastic leukaemia (ALL)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6dbb59721ed9a0f546d22360b2b10aa
https://doi.org/10.1158/1538-7445.am2017-4321
https://doi.org/10.1158/1538-7445.am2017-4321
Autor:
Jean-Pierre Bourquin, Scott McComb, Martin Stanulla, Cornelia Eckert, Júlia Aguadé-Gorgorió, Beat Bornhauser, Gunnar Cario
Publikováno v:
Cancer Research. 76:3548-3548
Dysregulation of apoptosis constitutes a general mechanism for refractory acute lymphoblastic leukemia (ALL) to escape cell death during chemotherapy. We have assessed the potential of SMAC mimetic compounds (SM) to eradicate drug resistant ALL by bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec7de4d49adf5d86c783de389e112e14
https://doi.org/10.1158/1538-7445.am2016-3548
https://doi.org/10.1158/1538-7445.am2016-3548