Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jørn M. Sonnergaard"'
Autor:
Jørn M. Sonnergaard
Publikováno v:
Journal of pharmaceutical sciences. 110(3)
This investigation contains a critical survey of a collection of five well-known and often used standard models in pharmaceutical technology. The basic idea is to use the recognised Ockham's razor as a tool in search for simpler methods or explanatio
Autor:
P. Olsen, Milad Khorasani, José Manuel Amigo, Jukka Rantanen, Jørn M. Sonnergaard, Poul Bertelsen
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 109:11-17
The porosity of roller compacted ribbon is recognized as an important critical quality attribute which has a huge impact on the final product quality. The purpose of this study was to investigate the use of near-infrared chemical imaging (NIR-CI) for
Publikováno v:
Powder Technology. 183:213-219
The source of variation in the full scale processability of 131 batches of the active pharmaceutical ingredient 5-aminosalicylic acid was investigated. The variation in processability, seen in the amount of granulation liquid needed for extrusion, wa
Publikováno v:
International Journal of Pharmaceutics. 342:115-123
The effects of roller compaction process parameters, morphological forms of calcium carbonate and particle size of sorbitol on flow, compaction and compression properties were investigated. The morphology of the calcium carbonate and the sorbitol par
Autor:
Jørn M. Sonnergaard
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 63:270-277
The purpose of this study is to investigate and to quantify the compactibility of pharmaceutical powders by a simple linear relationship between the diametral compressive strength of tablets and the applied compaction pressure. The mechanical strengt
Publikováno v:
European Journal of Pharmaceutical Sciences. 18:191-196
A digital image analysis method for the estimation of mean pellet size and coating thickness employing optical microscopy was evaluated. The coating thickness was expressed as the difference in mean projected area radius of the uncoated and the coate
Autor:
Jørn M. Sonnergaard
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 53:353-359
The distribution of a given set of data is important since most parametric statistical tests are based on the assumption that the studied data are normal distributed. In analysis of fracture mechanics the Weibull distribution is widely used and the d
Autor:
Jørn M. Sonnergaard, Anette Müllertz, Dhara Raijada, Claus Cornett, Jukka Rantanen, Tommy Munk
Publikováno v:
Journal of pharmaceutical sciences. 103(3)
The present study introduces a miniaturized high-throughput platform to understand the influence of excipients on the performance of oral solid dosage forms during early drug development. Wet massing of binary mixtures of the model drug (sodium napro
Autor:
Jørn M. Sonnergaard
Publikováno v:
Journal of pharmaceutical sciences. 102(12)
A dimensionless index that quantifies the brittle or ductile character of tablets is presented. The work of failure (WOF) of crushed or broken flat tablets is calculated by numerical integration of the force–displacement measurement in a flexure te
Autor:
Joergen Garnaes, Johannes Khinast, Jukka Rantanen, Jørn M. Sonnergaard, Georg Scharrer, Søren Soegaard, Johan Boetker
Publikováno v:
Proceedings of The 2nd Electronic Conference on Pharmaceutical Sciences.
Tablet compaction consists of several stages and is thus challenging to describe in simple mathematical equations.1 Various numerical approaches have been applied to try and derive a more thorough understanding of the multiple interactions that occur