Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jørn Bech Laursen"'
Autor:
Margaret Tarpey, Tohru Fukai, David G. Harrison, S Kurz, Mark J. Somers, Jørn Bech Laursen, Bruce A. Freeman, Ascan Warnholtz, Louise McCann
Publikováno v:
Circulation. 103:1282-1288
Background —Altered endothelial cell nitric oxide (NO · ) production in atherosclerosis may be due to a reduction of intracellular tetrahydrobiopterin, which is a critical cofactor for NO synthase (NOS). In addition, previous literature suggests t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7850a455f79818e2f36d8be9519f2583
https://doi.org/10.1161/01.cir.103.9.1282
https://doi.org/10.1161/01.cir.103.9.1282
Autor:
Robert Alexander, C P Hammes, R M Medford, C L Sundell, David G. Harrison, Jørn Bech Laursen, Pradyumna E. Tummala, Xi-Lin Chen
Publikováno v:
Circulation. 100:1223-1229
Background —Cardiovascular ischemic events may occur more frequently in hypertensive patients with activated renin-angiotensin systems. We tested the hypothesis that angiotensin II (Ang II) may contribute to atherosclerosis by increasing expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee363796c1998a1b8608d1602eb07e64
https://doi.org/10.1161/01.cir.100.11.1223
https://doi.org/10.1161/01.cir.100.11.1223
Publikováno v:
The American Journal of Cardiology. 81:21A-29A
Organic nitrates like nitroglycerin are widely used in the treatment of ischemic heart disease. The magnitude and duration of their circulatory and anti-ischemic effects are, however, rapidly reduced during continuous treatment. Although the exact en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56282184a561db9e4ce3949a9bb2962d
https://doi.org/10.1016/s0002-9149(97)00994-6
https://doi.org/10.1016/s0002-9149(97)00994-6
Autor:
Jørn Bech Laursen, Hisashi Kai, Robert J. Lefkowitz, Toshiki Fukui, Martin Oppermann, R. Wayne Alexander, P. Reid Lyons, Nobukazu Ishizaka, Kathy K. Griendling
Publikováno v:
Journal of Biological Chemistry. 272:32482-32488
GRK5, a recently cloned member of the G protein-coupled receptor kinase family, has been shown to phosphorylate and participate in the desensitization of angiotensin II (Ang II) type 1A (AT1A) receptors. In this study, the effect of angiotensin II on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c83428cf65fb9dc7a6d9acaff1b2e4b4
https://doi.org/10.1074/jbc.272.51.32482
https://doi.org/10.1074/jbc.272.51.32482
Autor:
Sanjay Rajagopalan, Toshiki Fukui, Quinn Capers, David G. Harrison, William R. Berrington, Jørn Bech Laursen, Bruce A. Freeman, Pingping Lou, W. Robert Taylor, R. Wayne Alexander, Ichiro Mori, Kathy K. Griendling, Marschall S. Runge
Publikováno v:
Circulation Research. 80:838-844
Abstract Thrombin has been implicated as an important mediator of vascular lesion formation in atherosclerosis and restenosis. To investigate a potential role for thrombin signaling in the vascular response to hypertension, we have studied thrombin r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165db4f44ad0641d688f3ea958bc264f
https://doi.org/10.1161/01.res.80.6.838
https://doi.org/10.1161/01.res.80.6.838
Autor:
Margaret Tarpey, Bruce A. Freeman, Jørn Bech Laursen, Sanjay Rajagopalan, David G. Harrison, Zorina S. Galis
Publikováno v:
Circulation. 95:588-593
Background The major source of superoxide (·O 2 − ) in vascular tissues is an NADH/NADPH-dependent, membrane-bound oxidase. We have previously shown that this oxidase is activated in angiotensin II– but not norepinephrine-induced hypertension. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9cacfe5c99d02ccd74beb8aaaeadd4
https://doi.org/10.1161/01.cir.95.3.588
https://doi.org/10.1161/01.cir.95.3.588
Autor:
Peter Bie, Jacob Plange-RHULE, J. C. Atherton, Jørn Bech Laursen, Sten Christensen, Michael Shalmi
Publikováno v:
Clinical Science. 82:635-640
1. The influences of lithium dosage, urine flow rate and acute administration of amiloride on the renal handling of lithium in normal conscious dogs were investigated. 2. Lithium was administered in the diet at daily doses of 100 mg or 2 mg of lithiu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::105c420668494f1d2a896989bf6f6dcd
https://doi.org/10.1042/cs0820635
https://doi.org/10.1042/cs0820635
Publikováno v:
Heart. 79:93-95
A well known complication in the treatment of infectious endocarditis is development of neutropenia caused by treatment with antibiotics in high concentrations over long periods. Neutropenia often necessitates discontinuation of antibiotic treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac4abed536355eaea393675ad5cc362f
https://doi.org/10.1136/hrt.79.1.93
https://doi.org/10.1136/hrt.79.1.93
Autor:
Jørn Bech Laursen, David G. Harrison
Publikováno v:
Circulation. 95:14-16
In this issue of Circulation ,1 Zhang and coworkers provide convincing evidence that ACE inhibitors reduce myocardial oxygen consumption by preventing the degradation of bradykinin, which subsequently stimulates the release of nitric oxide (NO). They
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e6b9f95bc143dcffd000b4ca6ebe509
https://doi.org/10.1161/01.cir.95.1.14
https://doi.org/10.1161/01.cir.95.1.14
Autor:
Jan Aldershvile, Jørn Bech Laursen, Sioren Boesgaard, Henrik E. Poulsen, Simon Trautner, Inger Rubin
Publikováno v:
Free radical research. 35(4)
Thiols like glutathione may serve as reducing cofactors in the production of nitric oxide (NO) and protect NO from inactivation by radical oxygen species. Depletion of thiol compounds reduces NO-mediated vascular effects in vitro and in vivo. The mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaae7ba5521b5e905cb82cd13f0a2ec2
https://pubmed.ncbi.nlm.nih.gov/11697135
https://pubmed.ncbi.nlm.nih.gov/11697135