Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jørgen de Jonge"'
Autor:
Josien Lanfermeijer, Koen van de Ven, Harry van Dijken, Marion Hendriks, Cami M. P. Talavera Ormeño, Femke de Heij, Paul Roholl, José A. M. Borghans, Debbie van Baarle, Jørgen de Jonge
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract CD8 + T cells are promising targets for vaccination against influenza A virus (IAV) infection. Their induction via peptide vaccination is not trivial, because peptides are weakly immunogenic. One strategy to overcome this is by vaccination w
Externí odkaz:
https://doaj.org/article/dcf333a662a7405bb9eb73687aa9e066
Autor:
Josien Lanfermeijer, Koen van de Ven, Marion Hendriks, Harry van Dijken, Stefanie Lenz, Martijn Vos, José A. M. Borghans, Debbie van Baarle, Jørgen de Jonge
Publikováno v:
Vaccines, Vol 12, Iss 4, p 419 (2024)
To protect older adults against influenza A virus (IAV) infection, innovative strategies are imperative to overcome the decrease in protective immune response with age. One approach involves the boosting of CD8+ T cells at middle age that were previo
Externí odkaz:
https://doaj.org/article/1443c322a32b4f41befdae381878c67b
Autor:
Caroline Vilas Boas de Melo, Florence Peters, Harry van Dijken, Stefanie Lenz, Koen van de Ven, Lisa Wijsman, Angéla Gomersbach, Tanja Schouten, Puck B. van Kasteren, Judith van den Brand, Jørgen de Jonge
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT Nonpharmaceutical interventions (NPIs) to contain the SARS-CoV-2 pandemic drastically reduced human-to-human interactions, decreasing the circulation of other respiratory viruses, as well. Consequently, influenza virus circulation, which is
Externí odkaz:
https://doaj.org/article/22e21bb8bac04c818a7db006dfc07c8c
Autor:
Koen van de Ven, Harry van Dijken, Lisa Wijsman, Angéla Gomersbach, Tanja Schouten, Jolanda Kool, Stefanie Lenz, Paul Roholl, Adam Meijer, Puck B. van Kasteren, Jørgen de Jonge
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Improving COVID-19 intervention strategies partly relies on animal models to study SARS-CoV-2 disease and immunity. In our pursuit to establish a model for severe COVID-19, we inoculated young and adult male ferrets intranasally or intratracheally wi
Externí odkaz:
https://doaj.org/article/9892f515abb54410a4c2f9e7c4e1de17
Autor:
Peter C. Soema, Sietske K. Rosendahl Huber, Geert-Jan Willems, Ronald Jacobi, Marion Hendriks, Ernst Soethout, Wim Jiskoot, Jørgen de Jonge, Josine van Beek, Gideon F. A. Kersten, Jean-Pierre Amorij
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Influenza peptide antigens coding for conserved T cell epitopes have the capacity to induce cross-protective influenza-specific immunity. Short peptide antigens used as a vaccine, however, often show poor immunogenicity. In this study, we demonstrate
Externí odkaz:
https://doaj.org/article/688c54d00d8745a7ae75b0cdd6a09d4a
Autor:
Sietske K Rosendahl Huber, Jolien J Luimstra, Josine van Beek, Rieuwert Hoppes, Ronald H J Jacobi, Marion Hendriks, Kim Kapteijn, Casper Ouwerkerk, Boris Rodenko, Huib Ovaa, Jørgen de Jonge
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156462 (2016)
T cells are essential players in the defense against infection. By targeting the MHC class I antigen-presenting pathway with peptide-based vaccines, antigen-specific T cells can be induced. However, low immunogenicity of peptides poses a challenge. H
Externí odkaz:
https://doaj.org/article/932165a9574145e3b1a7b4fb759dfbc2
Autor:
Irina Isakova-Sivak, Jørgen de Jonge, Tatiana Smolonogina, Andrey Rekstin, Geert van Amerongen, Harry van Dijken, Justin Mouthaan, Paul Roholl, Victoria Kuznetsova, Elena Doroshenko, Vadim Tsvetnitsky, Larisa Rudenko
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102339 (2014)
H2N2 Influenza A caused the Asian flu pandemic in 1957, circulated for more than 10 years and disappeared from the human population after 1968. Given that people born after 1968 are naïve to H2N2, that the virus still circulates in wild birds and th
Externí odkaz:
https://doaj.org/article/8bf254488d9e4ae3bd4006388b2ae3d6
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
Communications Biology
Communications Biology
Traditional influenza vaccines primarily induce a narrow antibody response that offers no protection against heterosubtypic infections. Murine studies have shown that T cells can protect against a broad range of influenza strains. However, ferrets ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe8d8c40b0b181faaddb2942cfa95de
http://link.springer.com/article/10.1038/s42003-020-01278-5
http://link.springer.com/article/10.1038/s42003-020-01278-5
Autor:
Paul J.M. Roholl, Nicolas Collin, Harry van Dijken, Martin Friede, Paulo Lee Ho, José A Ferreira, Femke de Heij, Rineke de Jong, Eduardo Alfredo Adami, Sanne Spijkers, Milena Apetito Akamatsu, Justin Mouthaan, Willem Luytjes, Livia Brunner, Jørgen de Jonge
Publikováno v:
npj Vaccines, Vol 5, Iss 1, Pp 1-14 (2020)
npj Vaccines 5 (2020) 1
NPJ Vaccines
npj Vaccines, 5(1)
npj Vaccines 5 (2020) 1
NPJ Vaccines
npj Vaccines, 5(1)
Until universal influenza vaccines become available, pandemic preparedness should include developing classical vaccines against potential pandemic influenza subtypes. We here show that addition of SWE adjuvant, a squalene-in-water emulsion, to H7N9 s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67acd758cf33cc35254355ca43f18b8f
http://link.springer.com/article/10.1038/s41541-020-0187-4
http://link.springer.com/article/10.1038/s41541-020-0187-4
Autor:
Taha Azad, Alexander Dömling, Jørgen de Jonge, Harry van Goor, Marco A. Velasco-Velázquez, Angel J Ruiz-Moreno, Matthew Groves, John C. Bell, Alessandra Monti, Afsaneh Sadremomtaz, Zayana M Al-Dahmani, Jolanda M. Smit, Nunzianna Doti, Chao Wang, Debora de Jong
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 65(4), 2836-2847. AMER CHEMICAL SOC
Journal of Medicinal Chemistry, 65(4), 2836-2847. AMER CHEMICAL SOC
The SARS-CoV-2 viral spike protein S receptor-binding domain (S-RBD) binds ACE2 on host cells to initiate molecular events, resulting in intracellular release of the viral genome. Therefore, antagonists of this interaction could allow a modality for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7341ff3c356e30ffc5e8342429e449c
http://europepmc.org/articles/PMC8353989
http://europepmc.org/articles/PMC8353989