Výsledky vyhledávání - "Jørgen Søøøøøberg Petersen"

The Antiarrhythmic Peptide Analog Rotigaptide (ZP123) Stimulates Gap Junction Intercellular Communication in Human Osteoblasts and Prevents Decrease in Femoral Trabecular Bone Strength in Ovariectomized Rats

Autor: Zanne Henriksen, Jens-Erik Beck Jensen, Jørgen Søøøøøberg Petersen, Ole Helmer Sørensen, Susanne Syberg Hansen, Eddi Meier, Niklas Rye Jørgensen, Stefan Cuoni Teilmann

Publikováno v: Endocrinology. 146:4745-4754

Gap junctions play an important role in bone development and function, but the lack of pharmacological tools has hampered the gap junction research. The antiarrhythmic peptides stimulate gap junction communication between cardiomyocytes, but effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367767764455102658dfafdabd653b2f
https://doi.org/10.1210/en.2004-1414

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Discovery of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride (GAP-134)13, an orally active small molecule gap-junction modifier for the treatment of atrial fibrillation

Autor: Edward H. Kerns, Eric I. Rossman, Leonard McDonald, James K. Hennan, Qiang Wang, Bjarne Due Larsen, Christine Huselton, Li Di, John A. Butera, Kun Liu, Jørgen Søøøøøberg Petersen, Asaf Alimardanov, Gwen A. Morgan, Rayomand Unwalla, Robert E. Swillo

Publikováno v: Journal of medicinal chemistry. 52(4)

Rotigaptide (3) is an antiarrhythmic peptide that improves cardiac conduction by modifying gap-junction communication. Small molecule gap-junction modifiers with improved physical properties were identified from a Zealand Pharma peptide library using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566ea6a7cc1a58626de0e37de647e136
https://pubmed.ncbi.nlm.nih.gov/19175320

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Treatment with the gap junction modifier rotigaptide (ZP123) reduces infarct size in rats with chronic myocardial infarction

Autor: Ketil Haugan, James K. Hennan, Morten Schak Nielsen, Jørgen Søøøøøberg Petersen, Anne Louise Kjølbye, Niels Marcussen

Publikováno v: Journal of cardiovascular pharmacology. 47(2)

Treatment with non-selective drugs (eg, long-chain alcohols, halothane) that reduce gap junction intercellular communication (GJIC) is associated with reduced infarct size after myocardial infarction (MI). Therefore, it has been suggested that gap ju

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e48162ae5b47f86b3f64f2c5042c934
https://pubmed.ncbi.nlm.nih.gov/16495761

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