Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Jörn Dietrich"'
Autor:
Damian J. Ralser, Emmanuelle Herr, Luka de Vos, Zsófi Kulcsár, Romina Zarbl, Niklas Klümper, Gerrit H. Gielen, Alexander Philippe Maas, Friederike Hoffmann, Jörn Dietrich, Pia Kuster, Alexander Mustea, Nicole Glodde, Glen Kristiansen, Sebastian Strieth, Jennifer Landsberg, Dimo Dietrich
Publikováno v:
Biomarker Research, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Background Inducible T cell costimulator ICOS is an emerging target in immuno-oncology. The aim of this study was to investigate the epigenetic regulation of ICOS in melanoma by DNA methylation. Methods We comprehensively investigate ICOS DN
Externí odkaz:
https://doaj.org/article/e3bb36e51ff44e6f9b8d700fc99a8755
Autor:
Luka de Vos, Ingela Grünwald, Emma Grace Bawden, Jörn Dietrich, Kathrin Scheckenbach, Constanze Wiek, Romina Zarbl, Friedrich Bootz, Jennifer Landsberg, Dimo Dietrich
Publikováno v:
Epigenetics, Vol 15, Iss 11, Pp 1195-1212 (2020)
CTLA-4 blocking therapeutic antibodies are currently under investigation in head and neck squamous cell carcinoma (HNSCC). A better understanding of the epigenetic regulation of the CD28 superfamily members CD28, CTLA-4, and ICOS and their B7 ligands
Externí odkaz:
https://doaj.org/article/57166499a8bc49da998576e00116f167
Autor:
Anne Fröhlich, Judith Sirokay, Simon Fietz, Timo J. Vogt, Jörn Dietrich, Romina Zarbl, Mike Florin, Pia Kuster, Gonzalo Saavedra, Susana Ramírez Valladolid, Friederike Hoffmann, Lukas Flatz, Sandra S. Ring, Carsten Golletz, Torsten Pietsch, Sebastian Strieth, Peter Brossart, Gerrit H. Gielen, Glen Kristiansen, Friedrich Bootz, Jennifer Landsberg, Dimo Dietrich
Publikováno v:
EBioMedicine, Vol 59, Iss , Pp 102962- (2020)
Background: The co-receptor lymphocyte-activation gene-3 (LAG3, LAG-3, CD223) is a potential target for immune checkpoint inhibition immunotherapies. However, little is known about the biological and clinical significance of LAG3 DNA methylation in m
Externí odkaz:
https://doaj.org/article/e0df1f7dff7f4d3890cfd8c1b6d74e95
Autor:
Anne Fröhlich, Sophia Loick, Emma Grace Bawden, Simon Fietz, Jörn Dietrich, Eric Diekmann, Gonzalo Saavedra, Holger Fröhlich, Dennis Niebel, Judith Sirokay, Romina Zarbl, Gerrit H. Gielen, Glen Kristiansen, Friedrich Bootz, Jennifer Landsberg, Dimo Dietrich
Publikováno v:
EBioMedicine, Vol 52, Iss , Pp - (2020)
Background: Immunotherapy, including checkpoint inhibition, has remarkably improved prognosis in advanced melanoma. Despite this success, acquired resistance is still a major challenge. The T cell costimulatory receptor TNFRSF9 (also known as 4-1BB a
Externí odkaz:
https://doaj.org/article/6d94cbfe2baa48b3be285fced529a34c
Autor:
Lea Kristin Röver, Heidrun Gevensleben, Jörn Dietrich, Friedrich Bootz, Jennifer Landsberg, Diane Goltz, Dimo Dietrich
Publikováno v:
EBioMedicine, Vol 28, Iss C, Pp 97-104 (2018)
Immune checkpoints are important targets for immunotherapies. However, knowledge on the epigenetic modification of immune checkpoint genes is sparse. In the present study, we investigated promoter methylation of CTLA4, PD-L1, PD-L2, and PD-1 in diffu
Externí odkaz:
https://doaj.org/article/8a5f7b6745cf41e593c1bbc287880c4a
Autor:
Timo J. Vogt, Heidrun Gevensleben, Jörn Dietrich, Glen Kristiansen, Friedrich Bootz, Jennifer Landsberg, Diane Goltz, Dimo Dietrich
Publikováno v:
OncoImmunology, Vol 7, Iss 8 (2018)
Background: The adenosine A2a receptor (A2aR) and the adenosine synthesizing enzyme CD73 have recently evolved as a novel immunotherapeutic target. However, little is known about epigenetic modification of the encoding genes ADORA2A and NT5E. Methods
Externí odkaz:
https://doaj.org/article/7e07fc2c59654d6b85acb481496e086a
Publikováno v:
Journal of Systemics, Cybernetics and Informatics, Vol 10, Iss 4, Pp 5-10 (2012)
In order to identify new ways to prevent, diagnose and treat diseases, biobanks systematically collect samples of human tissues and population-wide data on health and lifestyle. Efficient access to population biobank data and to biomaterial is crucia
Externí odkaz:
https://doaj.org/article/646bb86617e447648c3f58dd618d5cab
Autor:
Christina Grimm, Lukas Chavez, Mireia Vilardell, Alexandra L Farrall, Sascha Tierling, Julia W Böhm, Phillip Grote, Matthias Lienhard, Jörn Dietrich, Bernd Timmermann, Jörn Walter, Michal R Schweiger, Hans Lehrach, Ralf Herwig, Bernhard G Herrmann, Markus Morkel
Publikováno v:
PLoS Genetics, Vol 9, Iss 2, p e1003250 (2013)
Aberrant CpG methylation is a universal epigenetic trait of cancer cell genomes. However, human cancer samples or cell lines preclude the investigation of epigenetic changes occurring early during tumour development. Here, we have used MeDIP-seq to a
Externí odkaz:
https://doaj.org/article/f1689bb6ce554651818e5958827f19fb
Autor:
Friederike Hoffmann, Anne Fröhlich, Judith Sirokay, Luka de Vos, Romina Zarbl, Jörn Dietrich, Sebastian Strieth, Jennifer Landsberg, Dimo Dietrich
Publikováno v:
Melanoma Research. 33:116-125
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5400316b9cba2a590b78fbd019199d7c
https://doi.org/10.1097/cmr.0000000000000879
https://doi.org/10.1097/cmr.0000000000000879
Autor:
Luka, de Vos, Tzaitel Maria, Carrillo Cano, Romina, Zarbl, Niklas, Klümper, Damian Johannes, Ralser, Alina, Franzen, Emmanuelle, Herr, Jennis, Gabrielpillai, Timo Jakob, Vogt, Jörn, Dietrich, Sebastian, Strieth, Jennifer, Landsberg, Dimo, Dietrich
Publikováno v:
Journal of Immunotherapy. 45:324-334
Uveal melanoma (UM) is an aggressive disease with poor response to oncological treatment, including immunotherapy. Loss of the epigenetic modifier BRCA1-associated protein 1 (BAP1) function drives UM oncogenesis and is associated with an immune-suppr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4631cd7e7aa1c88e727a0b6f5efa9611
https://doi.org/10.1097/cji.0000000000000429
https://doi.org/10.1097/cji.0000000000000429