Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Jörgen Ådén"'
Autor:
Ameeq Ul Mushtaq, Jörgen Ådén, Luke A. Clifton, Hanna Wacklin-Knecht, Mario Campana, Artur P. G. Dingeldein, Cecilia Persson, Tobias Sparrman, Gerhard Gröbner
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Through neutron reflectometry and NMR spectroscopy studies, Mushtaq et al study the full-length Bcl-2 protein reconstituted in lipid bilayers. They find that, in contrast to previously studied truncated, soluble protein versions, intact Bcl-2 is main
Externí odkaz:
https://doaj.org/article/04e38e0553dd4095833d3e485d2fc850
Autor:
Aftab Nadeem, Alexandra Berg, Hudson Pace, Athar Alam, Eric Toh, Jörgen Ådén, Nikola Zlatkov, Si Lhyam Myint, Karina Persson, Gerhard Gröbner, Anders Sjöstedt, Marta Bally, Jonas Barandun, Bernt Eric Uhlin, Sun Nyunt Wai
Publikováno v:
eLife, Vol 11 (2022)
The α-pore-forming toxins (α-PFTs) from pathogenic bacteria damage host cell membranes by pore formation. We demonstrate a remarkable, hitherto unknown mechanism by an α-PFT protein from Vibrio cholerae. As part of the MakA/B/E tripartite toxin, M
Externí odkaz:
https://doaj.org/article/0a8dd6b4c732412e88ada5ed73ee8d45
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008466 (2020)
Francisella tularensis, a highly infectious, intracellular bacterium possesses an atypical type VI secretion system (T6SS), which is essential for its virulence. The chaperone ClpB, a member of the Hsp100/Clp family, is involved in Francisella T6SS d
Externí odkaz:
https://doaj.org/article/3acc5d92aab74d2c8d1bb627b8d31343
Autor:
Rachel Kelly, Andrew G. Cairns, Jörgen Ådén, Fredrik Almqvist, Alexis-Pierre Bemelmans, Emmanuel Brouillet, Tommy Patton, Declan P. McKernan, Eilís Dowd
Publikováno v:
Biomolecules, Vol 11, Iss 11, p 1685 (2021)
Animal models of Parkinson’s disease, in which the human α-synuclein transgene is overexpressed in the nigrostriatal pathway using viral vectors, are widely considered to be the most relevant models of the human condition. However, although highly
Externí odkaz:
https://doaj.org/article/c447a4e33b7344ddb7f816064af2a6e0
Publikováno v:
Molecules, Vol 26, Iss 5, p 1467 (2021)
Evasion from programmed cell death (apoptosis) is the main hallmark of cancer and a major cause of resistance to therapy. Many tumors simply ensure survival by over-expressing the cell-protecting (anti-apoptotic) Bcl-2 membrane protein involved in ap
Externí odkaz:
https://doaj.org/article/50073a62cf95478b9bef02fb0a75a9af
Autor:
Santiago Esteban-Martín, Robert Bryn Fenwick, Jörgen Ådén, Benjamin Cossins, Carlos W Bertoncini, Victor Guallar, Magnus Wolf-Watz, Xavier Salvatella
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 7, p e1003721 (2014)
Correlated inter-domain motions in proteins can mediate fundamental biochemical processes such as signal transduction and allostery. Here we characterize at structural level the inter-domain coupling in a multidomain enzyme, Adenylate Kinase (AK), us
Externí odkaz:
https://doaj.org/article/2f49603ff3f7441abbf15bf33c58276a
Publikováno v:
Journal of Chemical Information and Modeling. 63:1556-1569
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a46dc1c327866492325da1735a77dde
https://doi.org/10.1021/acs.jcim.2c01629
https://doi.org/10.1021/acs.jcim.2c01629
Autor:
Fredrik Almqvist, Souvik Sarkar, Anders Olofsson, Mohit Tyagi, Pardeep Singh, Jaideep B. Bharate, Jörgen Ådén, Dan E. Adolfsson, Anna L. Gharibyan, Sanduni Wasana Jayaweera, Anita Kiss
Publikováno v:
The Journal of Organic Chemistry
Reaction of thiazoline fused 2-pyridones with alkyl halides in the presence of cesium carbonate opens the thiazoline ring via S-alkylation and generates N-alkenyl functionalized 2-pyridones. In the reaction with propargyl bromide, the thiazoline ring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2067b1552fb6c2e0fef22c5f8d64dc10
http://europepmc.org/articles/PMC8650012
http://europepmc.org/articles/PMC8650012
Autor:
Luke A. Clifton, Hanna P. Wacklin-Knecht, Jörgen Ådén, Ameeq Ul Mushtaq, Tobias Sparrman, Gerhard Gröbner
Cellular clearance by apoptosis is essential in life. In its intrinsic (mitochondrial) pathway apoptotic members of the Bcl-2 (B cell CLL/lymphoma-2) protein family, such as Bax (Bcl-2-associated X) protein, perforate the mitochondrial outer membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edf19a2fcb241b54956520fa93aaf5be
https://doi.org/10.1101/2022.11.01.514672
https://doi.org/10.1101/2022.11.01.514672
Autor:
Jörgen Ådén, Pardeep Singh, Mohit Tyagi, Sanduni Wasana Jayaweera, Anders Olofsson, Adrian Deuschmann, Fredrik Almqvist, Anna L. Gharibyan, Anders E. G. Lindgren, Dan E. Adolfsson
Publikováno v:
The Journal of Organic Chemistry
A BF3×OEt2 catalyzed intramolecular Povarov reaction was used to synthesize a library of 15 chromenopyridine fused thiazolino-2-pyridone peptidomimetics. The reaction works with a range of O-alkylated salicylaldehydes and amino functionalized thiazo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc585e0880abcb5117ac3b4539093182
https://doi.org/10.1021/acs.joc.0c01699
https://doi.org/10.1021/acs.joc.0c01699