Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jörg-Robert Leheste"'
Autor:
Thomas E. Willnow, Erik Ilsø Christensen, John C. Fyfe, Morten Nielsen, Søren K. Moestrup, Pierre J. Verroust, Renata Kozyraki, Rahul Ray, Albert de la Chapelle, Christian Jacobsen, Jörg Robert Leheste, Anders Nykjaer, Maria Aminoff, Jørgen Gliemann
Publikováno v:
Proceedings of the National Academy of Sciences. 98:13895-13900
Steroid hormones are central regulators of a variety of biological processes. According to the free hormone hypothesis, steroids enter target cells by passive diffusion. However, recently we demonstrated that 25(OH) vitamin D 3 complexed to its plasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb17bde720e1765d19d7438f2787688c
https://doi.org/10.1073/pnas.241516998
https://doi.org/10.1073/pnas.241516998
Autor:
E. I. Christensen, Jörg-Robert Leheste, I Schousboe, Christian Jacobsen, S K Moestrup, Thomas E. Willnow
Publikováno v:
Journal of Clinical Investigation. 102:902-909
Screening of serum by using a surface plasmon resonance analysis assay identified beta2-glycoprotein-I/apolipoprotein H as a plasma component binding to the renal epithelial endocytic receptor megalin. A calcium-dependent megalin-mediated beta2-glyco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c31dc1fe042aea2a39d42715e84859ba
https://doi.org/10.1172/jci3772
https://doi.org/10.1172/jci3772
Autor:
Uwe Schlichting, Anders Nykjaer, Maren Wellner, Eckehard Wolf, Jörg Robert Leheste, Ingrid Renner-Müller, Flemming Melsen, Pernille Jansen, Thomas E. Willnow, Sebastian Bachmann, Troels T. Andreassen
Publikováno v:
The FASEB Journal. 17:247-249
Megalin is an endocytic receptor highly expressed in the proximal tubules of the kidney. Recently, we demonstrated that this receptor is essential for the renal uptake and conversion of 25-OH vitamin D3 to 1,25-(OH)2 vitamin D3, a central step in vit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::820474db6c89e7a550064af328c4c7fe
https://doi.org/10.1096/fj.02-0578fje
https://doi.org/10.1096/fj.02-0578fje
Autor:
Jörg-Robert Leheste, Michael Gotthardt, Saori Takahashi, Erik Ilsø Christensen, Christian Schmitz, Volkmar Gross, Friedrich C. Luft, Thomas E. Willnow, Stephan Hinderlich, Henrik Vorum
Publikováno v:
Schmitz, C, Gotthardt, M, Hinderlich, S, Leheste, J-R, Gross, V, Vorum, H, Christensen, E I, Luft, F C, Takahashi, S & Willnow, T E 2000, ' Normal blood pressure and plasma renin activity in mice lacking the renin-binding protein, a cellular renin inhibitor ' Journal of Biological Chemistry, vol. 275, pp. 15357-15362 .
In renal extracts, some renin is present as “high molecular weight renin,” a heterodimeric complex of renin with the 46-kDa renin-binding protein (RnBP), also known asN-acyl-d-glucosamine 2-epimerase. Because RnBP specifically inhibits renin acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638a67fc9db8a432d5095ac820ff2b19
https://pure.au.dk/portal/da/publications/normal-blood-pressure-and-plasma-renin-activity-in-mice-lacking-the-reninbinding-protein-a-cellular-renin-inhibitor(dbd48660-084b-11dc-bee9-02004c4f4f50).html
https://pure.au.dk/portal/da/publications/normal-blood-pressure-and-plasma-renin-activity-in-mice-lacking-the-reninbinding-protein-a-cellular-renin-inhibitor(dbd48660-084b-11dc-bee9-02004c4f4f50).html
Autor:
Jörg-Robert Leheste, Christian Jacobsen, Pierre Aucouturier, Jan Hilpert, Boris Rolinski, Erik Ilsø Christensen, Anders Nykjaer, Henrik Vorum, Jan Øivind Moskaug, Thomas E. Willnow, Albrecht Otto
Publikováno v:
Leheste, J F, Rolinski, B, Vorum, H, Hilpert, J, Nykjær, A, Jacobsen, C, Aucouturier, P, Moskaug, J O, Otto, A, Christensen, E I & Willnow, T E 1999, ' Megalin knockout mice as an animal model of low molecular weight proteinuria ' American Journal of Pathology, bind 155, s. 1361-1370 .
Leheste, J-R, Rolinski, B, Vorum, H, Hilpert, J, Nykjær, A, Jacobsen, C, Aucouturier, P, Moskaug, J Ø, Otto, A, Christensen, E I & Willnow, T E 1999, ' Megalin knockout mice as an animal model of low molecular weight proteinuria ' American Journal of Pathology, vol. 155, pp. 1361-1370 .
Leheste, J-R, Rolinski, B, Vorum, H, Hilpert, J, Nykjær, A, Jacobsen, C, Aucouturier, P, Moskaug, J Ø, Otto, A, Christensen, E I & Willnow, T E 1999, ' Megalin knockout mice as an animal model of low molecular weight proteinuria ' American Journal of Pathology, vol. 155, pp. 1361-1370 .
Megalin is an endocytic receptor expressed on the luminal surface of the renal proximal tubules. The receptor is believed to play an important role in the tubular uptake of macromolecules filtered through the glomerulus. To elucidate the role of mega
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89695c6f4c9180dacaed97d80f444e31
https://pure.au.dk/portal/da/publications/megalin-knockout-mice-as-an-animal-model-of-low-molecular-weight-proteinuria(335e82e0-955d-11da-bee9-02004c4f4f50).html
https://pure.au.dk/portal/da/publications/megalin-knockout-mice-as-an-animal-model-of-low-molecular-weight-proteinuria(335e82e0-955d-11da-bee9-02004c4f4f50).html