Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jörg-Christian Heinrich"'
Autor:
Melissa F Adasme, Daniele Parisi, Kristien Van Belle, Sebastian Salentin, V Joachim Haupt, Gary S Jennings, Jörg-Christian Heinrich, Jean Herman, Ben Sprangers, Thierry Louat, Yves Moreau, Michael Schroeder
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233089 (2020)
Many drugs are promiscuous and bind to multiple targets. On the one hand, these targets may be linked to unwanted side effects, but on the other, they may achieve a combined desired effect (polypharmacology) or represent multiple diseases (drug repos
Externí odkaz:
https://doaj.org/article/682c47392a2d44ffb4edd44602bd8f10
Autor:
Daniele Parisi, Jörg-Christian Heinrich, V. Joachim Haupt, Melissa F. Adasme, Michael Schroeder, Kristien Van Belle, Thierry Louat, Gary Jennings, Yves Moreau, Jean Herman, Ben Sprangers, Sebastian Salentin
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 5, p e0233089 (2020)
PLoS ONE, Vol 15, Iss 5, p e0233089 (2020)
Many drugs are promiscuous and bind to multiple targets. On the one hand, these targets may be linked to unwanted side effects, but on the other, they may achieve a combined desired effect (polypharmacology) or represent multiple diseases (drug repos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65599f42f8b22eca2d778b555662a38
http://europepmc.org/articles/PMC7252619
http://europepmc.org/articles/PMC7252619
Autor:
Jörg-Christian Heinrich, Rudolf Fahrig
Publikováno v:
Biomed Data Journal. 1:7-9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::154a62f33da84c1d707fa6684aabc3ea
https://doi.org/10.11610/bmdj.01201
https://doi.org/10.11610/bmdj.01201
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 137:1349-1361
Several reports describe the importance of the chaperone HSP27 (HSPB1) in cancer progression, and the demand for drugs that modulate HSPB1-activity is increasing rapidly. We reported earlier that RP101 (Bromovinyldeoxyuridine, BVDU, Brivudine) improv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5dad848f36fee84acc2641fbc71b373
https://doi.org/10.1007/s00432-011-1005-1
https://doi.org/10.1007/s00432-011-1005-1
Autor:
Gihan Dawelbait, Christian Pilarsky, Yanju Zhang, Jörg-Christian Heinrich, Michael Schroeder, Christof Winter, Robert Grützmann
Publikováno v:
ISMB/ECCB (Supplement of Bioinformatics)
Motivation: Pancreatic ductal adenocarcinoma (PDAC) eludes early detection and is characterized by its aggressiveness and resistance to current therapies. A number of gene expression screens have been carried out to identify genes differentially expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc93b9646ac71a4673f5ae9870dd3f6
https://doi.org/10.1093/bioinformatics/btm188
https://doi.org/10.1093/bioinformatics/btm188
Autor:
Denise Sonntag, Andreas Liebert, Christian Praha, Jörg-Christian Heinrich, D. Quietzsch, Mathias Hänel, Rudolf Fahrig, Georg Krupitza, Roland M Schmid, Stefan Boeck, Volker Heinemann
Publikováno v:
Anti-cancer drugs. 17(9)
RP101 [(E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU)], which supports apoptosis and prevents the acquisition of chemoresistance, was tested in cultured human pancreatic tumor cells. RP101 downregulated uridine phosphorylase, a marker of poor prognosis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56a7cf46bdb729b7f8fd2771752ff16
https://pubmed.ncbi.nlm.nih.gov/17001178
https://pubmed.ncbi.nlm.nih.gov/17001178
Autor:
Rudolf, Fahrig, Jörg-Christian, Heinrich, Bernd, Nickel, Falk, Wilfert, Christina, Leisser, Georg, Krupitza, Christian, Praha, Denise, Sonntag, Beate, Fiedler, Harry, Scherthan, Heinrich, Ernst
Publikováno v:
Cancer research. 63(18)
Induced chemoresistance leads to the reduction of apoptotic responses. Although several drugs are in development that circumvent or decrease existing chemoresistance, none has the potential to prevent or reduce its induction. Here, we present data fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2fa5f6456f75d5adf180669c6fbdff56
https://pubmed.ncbi.nlm.nih.gov/14522895
https://pubmed.ncbi.nlm.nih.gov/14522895
Publikováno v:
Antisense research and development. 5(2)
Different strains of transgenic Drosophila melanogaster carrying one, two, or three copies of a heat-shock promoter 70 (hsp70)-driven catalytic antisense RNA gene, directed against the white gene, were investigated for the expression level of ribozym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ad9a59b658e9ecea160d4f951f965ce
https://pubmed.ncbi.nlm.nih.gov/7580120
https://pubmed.ncbi.nlm.nih.gov/7580120
Publikováno v:
Developmental genetics. 14(4)
We have transformed Drosophila melanogaster with a DNA construct encoding a catalytic antisense RNA directed against the primary white gene RNA transcript. Total RNA isolated from transformed flies was shown to catalyze the specific cleavage of in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493be02d22023050b7aacd10abac11f3
https://pubmed.ncbi.nlm.nih.gov/7693385
https://pubmed.ncbi.nlm.nih.gov/7693385