Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Jörg Zwirner"'
Publikováno v:
The Journal of Immunology. 179:3958-3965
Human defensins are natural peptide antibiotics. On the basis of the position and bonding of six conserved cysteine residues, they are divided into two families, designated α- and β-defensins. Human α-defensins are expressed predominantly in neutr
Autor:
Heike Unsoeld, Katja Mueller, Jörg Zwirner, Hanspeter Pircher, Christian Bogdan, Ulrike Schleicher, David Voehringer
Publikováno v:
International Immunology. 19:1281-1289
The CC chemokine receptor 7 (CCR7) and its two ligands, CCL21 and CCL19, play an important role in migration of immune cells to lymphoid tissue. To analyze the function of CCR7 in T cell immunity to infectious agents in vivo, transgenic (tg) mice exp
Publikováno v:
Immunobiology. 212:129-139
To assess published evidence of anaphylatoxin receptor expression in renal tubular epithelial cells, monoclonal antibodies (mAbs) against human, mouse and rat receptors for C5a and C3a (C5aR, C3aR) were raised using receptor-expressing transfectants
Publikováno v:
The Journal of Immunology. 177:968-975
Infection or immunization induces heterogeneous memory T cell subsets, but their origin and protective value against infection are unclear. In this study, we report the functional characterization of two memory Th subsets, defined by expression of in
Autor:
John D. Lambris, Nancy S. Herman, Manoj K. Pandey, Jörg Köhl, Ian P. Lewkowich, Jeffrey A. Whitsett, Jörg Zwirner, Lihua Wang, Georgia Sfyroera, Ralf Baelder, Alyssa Sproles, Marsha Wills-Karp, Craig Gerard, Jennifer Best, Heiko Hawlisch
Publikováno v:
Journal of Clinical Investigation. 116:783-796
Complement component 5 (C5) has been described as either promoting or protecting against airway hyperresponsiveness (AHR) in experimental allergic asthma, suggesting pleomorphic effects of C5. Here we report that local pharmacological targeting of th
Autor:
Marcela Pekna, Max Albert Hietala, Ulrika Wilhelmsson, Jörg Zwirner, Ioan Davies, Rick A. Wetsel, Ann Katrin Nilsson, Andrew P. Fotheringham, Craig Gerard, Milos Pekny, Yalda Rahpeymai
Publikováno v:
The EMBO Journal. 25:1364-1374
Through its involvement in inflammation, opsonization, and cytolysis, the complement protects against infectious agents. Although most of the complement proteins are synthesized in the central nervous system (CNS), the role of the complement system i
Autor:
J. Sjef Verbeek, Jörg Zwirner, Varsha Kumar, Reinhold E. Schmidt, J. Engelbert Gessner, Syed Raza Ali, Stephanie Konrad
Publikováno v:
Journal of Clinical Investigation. 116:512-520
Complement C5a, a potent anaphylatoxin, is a candidate target molecule for the treatment of inflammatory diseases, such as myocardial ischemia/reperfusion injury, RA, and the antiphospholipid syndrome. In contrast, up until now, no specific contribut
Autor:
Nelli Shushakova, Roland P. Piekorz, Karsten Spicher, Nico van Rooijen, Stephanie Konrad, Lutz Birnbaumer, Josef S. Verbeek, Jörg Köhl, Jill W. C. Claassens, Julia Skokowa, Olga Felda, Jörg Zwirner, Reinhold E. Schmidt, Varsha Kumar, J. Engelbert Gessner, Bernd Nürnberg, Syed R. Ali
Publikováno v:
The Journal of Immunology. 174:3041-3050
Complement and FcgammaR effector pathways are central triggers of immune inflammation; however, the exact mechanisms for their cooperation with effector cells and their nature remain elusive. In this study we show that in the lung Arthus reaction, th
Autor:
Christine Kinnon, Samantha J. Hardy, Adrian J. Thrasher, Michael P. Blundell, Joanna Sinclair, Gareth E. Jones, Jörg Zwirner, Oliver Schulz, David R. Katz, Jessica Strid, Sofia de Noronha
Publikováno v:
Blood. 105:1590-1597
Regulated migration and spatial localization of dendritic cells (DCs) are critical events during the initiation of physiologic immune responses and maintenance of tolerance. Here we have used cells deficient in the Wiskott-Aldrich syndrome protein (W
Autor:
Jörg Zwirner, Afsaneh Soruri
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 37:241-245
Dendritic cells (DC) represent the most potent antigen-presenting cells (APC) of the immune system for their unique capability of presenting antigen to T-cells. Their use as cellular vaccines after charging with antigen ex vivo has been shown to indu