Genetic interference with HvNotch provides new insights into the role of the Notch-signalling pathway for developmental pattern formation in Hydra

Autor: Qin Pan, Moritz Mercker, Alexander Klimovich, Jörg Wittlieb, Anna Marciniak-Czochra, Angelika Böttger

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)

Abstract The Notch-signalling pathway plays an important role in pattern formation in Hydra. Using pharmacological Notch inhibitors (DAPT and SAHM1), it has been demonstrated that HvNotch is required for head regeneration and tentacle patterning in H

Externí odkaz: https://doaj.org/article/a11ea9e31c7441e98a306ca4a52fed3c

A novel gene family controls species-specific morphological traits in Hydra.

Autor: Konstantin Khalturin, Friederike Anton-Erxleben, Sylvia Sassmann, Jörg Wittlieb, Georg Hemmrich, Thomas C G Bosch

Publikováno v: PLoS Biology, Vol 6, Iss 11, p e278 (2008)

Understanding the molecular events that underlie the evolution of morphological diversity is a major challenge in biology. Here, to identify genes whose expression correlates with species-specific morphologies, we compared transcriptomes of two close

Externí odkaz: https://doaj.org/article/53f4f7f8bb4044bea9b2cd0e97f15c78

Transgenesis in Hydra to characterize gene function and visualize cell behavior

Autor: Jörg Wittlieb, Thomas C. G. Bosch, Alexander Klimovich

Publikováno v: Nature Protocols. 14:2069-2090

The freshwater polyp Hydra is a cnidarian used as a model organism in a number of fields, including the study of the origin and evolution of developmental mechanisms, aging, symbiosis and host–microbe interactions. Here, we describe a procedure for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d7360dc35b62bab702d075c33c9b1f
https://doi.org/10.1038/s41596-019-0173-3

A secreted antibacterial neuropeptide shapes the microbiome of Hydra

Autor: Andrea P. Murillo Rincón, Eva-Maria Herbst, Jörg Wittlieb, Friederike Anton-Erxleben, Martin Schwentner, Trudy M. Wassenaar, René Augustin, Sebastian Fraune, Thomas C. G. Bosch, Katja Schröder, Joachim Grötzinger

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Nature Communications

Colonization of body epithelial surfaces with a highly specific microbial community is a fundamental feature of all animals, yet the underlying mechanisms by which these communities are selected and maintained are not well understood. Here, we show t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d8932f5fd962247a37f0240f513952
https://doaj.org/article/b06c2c46e7bd4744804e80fc8a25bed4

Real time dynamics of β-catenin expression during hydra development, regeneration and wnt signalling activation

Autor: Alexander Klimovich, Andrea Bassi, Angela Tino, Alessia Candeo, Roberta Iachetta, Claudia Tortiglione, Giada Onorato, Jörg Wittlieb, Martina Blasio, Alfredo Ambrosone, Cosimo D'Andrea, Nunzia Scotti, Daniela Intartaglia

Publikováno v: The International Journal of Developmental Biology
The International journal of developmental biology 62 (2018). doi:10.1387/ijdb.180092ct
info:cnr-pdr/source/autori:Roberta Iachetta, Alfredo Ambrosone, Alexander Klimovich, Jörg Wittlieb, Giada Onorato, Alessia Candeo, Cosimo D'andrea, Daniela Intartaglia, Nunzia Scotti, Martina Blasio, Angela Tino, Andrea Bassi, Claudia Tortiglione/titolo:Real time dynamics of ?-catenin expression during Hydra development, regeneration and Wnt signalling activation/doi:10.1387%2Fijdb.180092ct/rivista:The International journal of developmental biology/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:62

Understanding the dynamic cellular behaviours driving morphogenesis and regeneration is a long-standing challenge in biology. Live imaging, together with genetically encoded reporters, may provide the necessary tool to address this issue, permitting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305993953968b3925847ac9c31e90e71
http://hdl.handle.net/11311/1087168