Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Jörg W, Wegener"'
Autor:
Jörg W. Wegener, Ahmed Wagdi, Eva Wagner, Dörthe M. Katschinski, Gerd Hasenfuss, Tobias Bruegmann, Stephan E. Lehnart
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Missense mutations in the cardiac ryanodine receptor type 2 (RyR2) characteristically cause catecholaminergic arrhythmias. Reminiscent of the phenotype in patients, RyR2-R2474S knockin mice develop exercise-induced ventricular tachyarrhythmias. In ca
Externí odkaz:
https://doaj.org/article/710f973264f24e6d879ff31f3f3c4fa1
Autor:
Sören Brandenburg, Jan Pawlowitz, Vanessa Steckmeister, Hariharan Subramanian, Dennis Uhlenkamp, Marina Scardigli, Mufassra Mushtaq, Saskia I. Amlaz, Tobias Kohl, Jörg W. Wegener, Demetrios A. Arvanitis, Despina Sanoudou, Leonardo Sacconi, Gerd Hasenfuß, Niels Voigt, Viacheslav O. Nikolaev, Stephan E. Lehnart
Publikováno v:
Journal of Molecular and Cellular Cardiology. 165:141-157
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::facbdf1c192e2b5047b1770eb61b2bd1
https://doi.org/10.1016/j.yjmcc.2022.01.003
https://doi.org/10.1016/j.yjmcc.2022.01.003
Autor:
Filip Berisha, Cristina E. Molina, Jörg W. Wegener, Christiane Jungen, Gerd Hasenfuß, Konrad R. Götz, Stefan Blankenberg, Viacheslav O. Nikolaev, Stephan E. Lehnart, Dirk Westermann, Svenja Warnke, Alexander M. Bernhardt, Axel E. Kraft, Sören Brandenburg, Diana Lindner, Hariharan Subramanian, Ulrike Pape, Evaldas Girdauskas, Johannes Petersen, Christian Meyer, André Rüffer
Publikováno v:
Circulation Research. 129:81-94
Rationale: 3′,5′-cAMP is a ubiquitous second messenger which, upon β-AR (β-adrenergic receptor) stimulation, acts in microdomains to regulate cardiac excitation-contraction coupling by activating phosphorylation of calcium handling proteins. On
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::377795a2d8e01f6b9ceb37188007272f
https://doi.org/10.1161/circresaha.120.318234
https://doi.org/10.1161/circresaha.120.318234
Autor:
Sören, Brandenburg, Jan, Pawlowitz, Vanessa, Steckmeister, Hariharan, Subramanian, Dennis, Uhlenkamp, Marina, Scardigli, Mufassra, Mushtaq, Saskia I, Amlaz, Tobias, Kohl, Jörg W, Wegener, Demetrios A, Arvanitis, Despina, Sanoudou, Leonardo, Sacconi, Gerd, Hasenfuß, Niels, Voigt, Viacheslav O, Nikolaev, Stephan E, Lehnart
Publikováno v:
Journal of molecular and cellular cardiology. 165
Axial tubule junctions with the sarcoplasmic reticulum control the rapid intracellular Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5a1e174e4eba12287f931776e93be709
https://pubmed.ncbi.nlm.nih.gov/35033544
https://pubmed.ncbi.nlm.nih.gov/35033544
Autor:
Enrico Patrucco, Alexander Dietrich, Lutz Birnbaumer, Franz Hofmann, Jörg W. Wegener, Florian Loga, Katrin Domes
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 467:2229-2234
Signaling via cGMP-dependent protein kinase I (cGKI) and canonical transient receptor potential (TRPC) channels appears to be involved in the regulation of cardiac hypertrophy. Recent evidence suggests that TRPC channels are targets for cGKI, and pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d2c9947aa566432e84571ff2520fdb
https://doi.org/10.1007/s00424-014-1682-0
https://doi.org/10.1007/s00424-014-1682-0
Publikováno v:
The FASEB Journal. 28:1044-1048
α1-Adrenergic stimulation increases blood vessel tone in mammals. This process involves a number of intracellular signaling pathways that include signaling via phospholipase C, diacylglycerol (DAG), and protein kinase C. So far, it is not certain wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffbbb7f93867d5f4612b42367c9b59eb
https://doi.org/10.1096/fj.13-237925
https://doi.org/10.1096/fj.13-237925
Autor:
Franz Hofmann, Anurag Kumar Singh, Pascal Weinmeister, Dagmar Krueger, Ursula Seidler, Sabine Klein, Fang Xiao, Beate Spiessberger, Jörg W. Wegener, Dieter Saur, Robert Lukowski, Wen Zheng, Michael Schemann
Publikováno v:
The FASEB Journal. 26:1745-1754
Brief contact of the duodenal mucosa with luminal acid elicits a long-lasting bicarbonate (HCO(3)(-)) secretory response, which is believed to be the primary protective mechanism against mucosal damage. Here, we show that cGMP-dependent protein kinas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51fb790e4cf9d5e1fb17608cdf913c0
https://doi.org/10.1096/fj.11-200394
https://doi.org/10.1096/fj.11-200394
Publikováno v:
European Journal of Pharmacology. 670:266-271
cGMP-dependent kinase I (cGKI) is a major mediator of smooth muscle relaxation and exists in two isoforms, α and β. Both isoforms are supposed to mediate their effects via different intracellular signaling pathways. To verify this concept, the kine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53fb68cf3e7ceef025f47b7b799c11f
https://doi.org/10.1016/j.ejphar.2011.07.048
https://doi.org/10.1016/j.ejphar.2011.07.048
Autor:
Stefanie R. Fischer, Franz Hofmann, Sven Moosmang, Katharina Köstner, Andrea Welling, Anne Blaich, Jörg W. Wegener
Publikováno v:
Proceedings of the National Academy of Sciences. 107:10285-10289
Activity-dependent means of altering calcium (Ca 2 + ) influx are assumed to be of great physiological consequence, although definitive tests of this assumption have only begun to emerge. Facilitation and inactivation offer two opposing, activity-dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f88100deb26428f6f15021818f55617
https://doi.org/10.1073/pnas.0914287107
https://doi.org/10.1073/pnas.0914287107
Publikováno v:
The FASEB Journal. 24:2651-2659
Here we present functional and biochemical evidence for a Ca(2+) channel (Ca(V)1.2)/protein kinase C (PKC) signaling complex being a key player in muscarinic regulation of urinary bladder smooth muscle. Muscarinic stimulation induced Ca(2+) signals a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb5e0a39cd725c1b0ef4bc0e45174cd
https://doi.org/10.1096/fj.09-149856
https://doi.org/10.1096/fj.09-149856