Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jörg T, Regula"'
Autor:
Jörg T Regula, Peter Lundh von Leithner, Richard Foxton, Veluchamy A Barathi, Chui Ming Gemmy Cheung, Sai Bo Bo Tun, Yeo Sia Wey, Daiju Iwata, Miroslav Dostalek, Jörg Moelleken, Kay G Stubenrauch, Everson Nogoceke, Gabriella Widmer, Pamela Strassburger, Michael J Koss, Christian Klein, David T Shima, Guido Hartmann
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 11, Pp 1265-1288 (2016)
Abstract Anti‐angiogenic therapies using biological molecules that neutralize vascular endothelial growth factor‐A (VEGF‐A) have revolutionized treatment of retinal vascular diseases including age‐related macular degeneration (AMD). This stud
Externí odkaz:
https://doaj.org/article/71a747701bce4cbabf65b970e677ba81
Autor:
Jörg T Regula, Peter Lundh von Leithner, Richard Foxton, Veluchamy A Barathi, Chui Ming Gemmy Cheung, Sai Bo Bo Tun, Yeo Sia Wey, Daiju Iwata, Miroslav Dostalek, Jörg Moelleken, Kay G Stubenrauch, Everson Nogoceke, Gabriella Widmer, Pamela Strassburger, Michael J Koss, Christian Klein, David T Shima, Guido Hartmann
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 7, Pp 985-985 (2017)
Externí odkaz:
https://doaj.org/article/7b40d5bc3c9247c09518efa7de23d0dc
Autor:
Markus Thomas, Yvonne Kienast, Werner Scheuer, Monika Bähner, Klaus Kaluza, Christian Gassner, Frank Herting, Ulrich Brinkmann, Stefan Seeber, Anita Kavlie, Martin Welschof, Stefan Ries, K Michael Weidner, Jörg T Regula, Christian Klein
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e54923 (2013)
There is increasing experimental evidence for an important role of Angiopoietin-2 (Ang-2) in tumor angiogenesis and progression. In addition, Ang-2 is up-regulated in many cancer types and correlated with poor prognosis. To investigate the functional
Externí odkaz:
https://doaj.org/article/bc383949771b43a4a38b519f5fd75a2a
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 132:141-147
The increasing complexity of novel biotherapeutics such as bispecific antibodies or fusion proteins raises new challenges for functional characterization. When compared to standard antibodies, two individual interactions and the inter-dependency of b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8407b6dc9b421dae6c8f8eb9db2e86
https://doi.org/10.1016/j.jpba.2016.09.028
https://doi.org/10.1016/j.jpba.2016.09.028
Autor:
Klaus-Peter Künkele, Christian Gassner, Manfred Schwaiger, Tobias Manigold, Lothar Kling, Christian Klein, Diana Weininger, Jörg T. Regula, Philippe Ringler, Matthias E. Lauer, Alexandra Graff-Meyer, Sebastian Fenn, Julia J. Griese, Michael Molhoj, Hubert Kettenberger, Birgit Bossenmaier, Ulrich Brinkmann, Karl-Peter Hopfner, Steffen Dickopf, Claudio Sustmann, Henning Stahlberg, Wolfgang Schaefer
Publikováno v:
mAbs
High specificity accompanied with the ability to recruit immune cells has made recombinant therapeutic antibodies an integral part of drug development. Here we present a generic approach to generate two novel IgG-derived antibody formats that are bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0864e4ef485578dafe4129bccf4ef83
https://pubmed.ncbi.nlm.nih.gov/31526159
https://pubmed.ncbi.nlm.nih.gov/31526159
Autor:
Jörg T Regula, Peter Lundh von Leithner, Richard Foxton, Veluchamy A Barathi, Gemmy Cheung Chui Ming, Sai Bo Bo Tun, Yeo Sia Wey, Daiju Iwata, Miroslav Dostalek, Jörg Moelleken, Kay G Stubenrauch, Everson Nogoceke, Gabriella Widmer, Pamela Strassburger, Michael J Koss, Christian Klein, David T Shima, Guido Hartmann
Publikováno v:
EMBO Molecular Medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd49f15a228af63f60ef04e612c988a
https://doi.org/10.15252/emmm.201910666
https://doi.org/10.15252/emmm.201910666
Autor:
K. Michael Weidner, Hubert Kettenberger, Ulrich Brinkmann, Markus Thomas, Jörg T. Regula, Monika Baehner, Werner Scheuer, Christian Klein, Jürgen Michael Schanzer, Petra Hanke, Johannes Sam, Franz Osl, Stefan Seeber, Diana Weininger
Publikováno v:
mAbs
Vascular endothelial growth factor (VEGF)-A blockade has been validated clinically as a treatment for human cancers. Angiopoietin-2 (Ang-2) is a key regulator of blood vessel remodeling and maturation. In tumors, Ang-2 is up-regulated and an unfavora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39babf68907b9bf4441f9d675180129f
http://europepmc.org/articles/PMC4966847
http://europepmc.org/articles/PMC4966847
Autor:
Sabine Imhof-Jung, Stefan Lorenz, Michael Molhoj, Wolfgang Schaefer, Hans Rainer Völger, Jörg T. Regula, Christian Klein
Publikováno v:
mAbs. 8:49-55
The quadroma antibody represents the first attempt to produce a bispecific heterodimeric IgG antibody by somatic fusion of 2 hybridoma cells each expressing monoclonal antibodies with distinctive specificities. However, because of random heavy and li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d7b9d159a91a40e4f64ac60cac6cd62
https://doi.org/10.1080/19420862.2015.1111498
https://doi.org/10.1080/19420862.2015.1111498
Autor:
Everson Nogoceke, Kay Stubenrauch, Chui Ming Gemmy Cheung, Peter Lundh von Leithner, Sai Bo Bo Tun, Jörg Moelleken, Pamela Strassburger, Yeo Sia Wey, Daiju Iwata, David T. Shima, Gabriella Widmer, Jörg T. Regula, Veluchamy A Barathi, Michael Janusz Koss, Miroslav Dostálek, Christian Klein, Guido Hartmann, Richard Foxton
Publikováno v:
EMBO Molecular Medicine
Anti‐angiogenic therapies using biological molecules that neutralize vascular endothelial growth factor‐A (VEGF‐A) have revolutionized treatment of retinal vascular diseases including age‐related macular degeneration (AMD). This study reports
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7449ecfde7f87b302f93b6564a7eb94d
https://pubmed.ncbi.nlm.nih.gov/31040127
https://pubmed.ncbi.nlm.nih.gov/31040127
Autor:
Claudio Sustmann, Kay Stubenrauch, Rebecca Croasdale, Ulrich Brinkmann, Jörg T. Regula, Christian Klein, Markus Thomas, Wolfgang Schaefer, Jürgen Michael Schanzer, Hubert Kettenberger
Publikováno v:
mAbs. 4:653-663
The development of bispecific antibodies has attracted substantial interest, and many different formats have been described. Those specifically containing an Fc part are mostly tetravalent, such as stabilized IgG-scFv fusions or dual-variable domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a026f4b98f61c9ad929bd1067b7cce3d
https://doi.org/10.4161/mabs.21379
https://doi.org/10.4161/mabs.21379