Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Jörg Stürzebecher"'
Autor:
Sandra Macedo-Ribeiro, Carla Almeida, Bárbara M Calisto, Thomas Friedrich, Reinhard Mentele, Jörg Stürzebecher, Pablo Fuentes-Prior, Pedro José Barbosa Pereira
Publikováno v:
PLoS ONE, Vol 3, Iss 2, p e1624 (2008)
Inhibitors of coagulation factors from blood-feeding animals display a wide variety of structural motifs and inhibition mechanisms. We have isolated a novel inhibitor from the cattle tick Boophilus microplus, one of the most widespread parasites of f
Externí odkaz:
https://doaj.org/article/333d356be7ee48f3aa83c482a4213c66
Autor:
Ulrike Bräuer, Petr Kolenko, Milton T. Stubbs, Christian Ursel, Andrea Schweinitz, Peter Steinmetzer, Daniel Rauh, Anastasia Tziridis, Torsten Steinmetzer, Piotr Neumann, Jörg Stürzebecher, Anja Menzel
Publikováno v:
Biological Chemistry. 395:891-903
A high-resolution crystallographic structure determination of a protein–ligand complex is generally accepted as the ‘gold standard’ for structure-based drug design, yet the relationship between structure and affinity is neither obvious nor stra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7106d9a6ccf5d192b7b41b9dd62c29cc
https://doi.org/10.1515/hsz-2014-0158
https://doi.org/10.1515/hsz-2014-0158
Autor:
Clemens Ruppert, Werner Seeger, Poornima Mahavadi, Philipp Markart, Andreas Günther, Susanne Greschus, Ralph T. Schermuly, Malgorzata Wygrecka, Ingrid Henneke, Martina Korfei, Rajkumar Savai, Jörg Stürzebecher
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 181:611-619
Rationale Lung cancer is the most common malignancy in humans. Urokinase (uPA) plays a crucial role in carcinogenesis by facilitating tumor cell invasion and metastasis. Objectives We investigated the effect of the highly specific urokinase inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c3e8967a32714481292beb4d5b7a0a5
https://doi.org/10.1164/rccm.200903-0342oc
https://doi.org/10.1164/rccm.200903-0342oc
Autor:
Andrea Schweinitz, Rainer Friedrich, Manuel E. Than, Daniel Dönnecke, Anne Stürzebecher, Jörg Stürzebecher, Wolfram Bode, Friedemann Müller, Torsten Steinmetzer, Oliver Schuster, Peter Steinmetzer, Kerstin Uhland
Publikováno v:
Journal of Medicinal Chemistry. 49:4116-4126
Matriptase is an epithelium-derived type II transmembrane serine protease and has been implicated in the activation of substrates such as pro-HGF/SF and pro-uPA, which are likely involved in tumor progression and metastasis. Through screening, we hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23fe21184a1eea6aaa942638cbf1bde0
https://doi.org/10.1021/jm051272l
https://doi.org/10.1021/jm051272l
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:228-234
The urokinase-type plasminogen activator (uPA) is a protein involved in tissue remodeling and other biological processes. The inhibitors of uPA have been shown to prevent the spread of metastasis and tumor growth, and accordingly this enzyme is widel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f77709ca2eaad8387ce44372fd39a97
https://doi.org/10.1016/j.bmcl.2005.08.089
https://doi.org/10.1016/j.bmcl.2005.08.089
Autor:
Jörg Stürzebecher, Torsten Steinmetzer
Publikováno v:
Current Medicinal Chemistry. 11:2297-2321
The trypsin-like serine protease thrombin is a multifunctional key enzyme at the final step of the coagulation cascade and is involved in the regulation of hemostasis and thrombosis. An increased activation of coagulation can result in severe thrombo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a1340f083979021d49068155bec9f9
https://doi.org/10.2174/0929867043364540
https://doi.org/10.2174/0929867043364540
Autor:
Torsten Steinmetzer, Jörg Stürzebecher
Publikováno v:
Pharmazie in unserer Zeit. 33:196-205
Thrombin ist eines der am intensivsten bearbeiteten Targets in der Wirkstoffentwicklung der vergangenen drei Jahrzehnte. Das Ziel, mit einem selektiven und oral wirksamen Thrombinhemmstoff das ideale Antikoagulans zu entwickeln, ist bisher noch nicht
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9aa1a2125f91a8f0f4a55b8fca9dd773
https://doi.org/10.1002/pauz.200400068
https://doi.org/10.1002/pauz.200400068
Autor:
Carsten Reckhart, Thomas Hilberg, Jörg Stürzebecher, Holger H. W. Gabriel, Dagmar Prasa, Doreen Gläser
Publikováno v:
European Journal of Applied Physiology. 90:639-642
For rehabilitation training it is recommended that the intensity of exercise should be clearly below the individual anaerobic threshold (IAT). We investigated blood coagulation, particularly endogenous thrombin potential (ETP) and fibrinolysis follow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09f303734248b3435bdc8d7f7739115
https://doi.org/10.1007/s00421-003-0907-2
https://doi.org/10.1007/s00421-003-0907-2
Autor:
Reinhold Schmidt, F. Grimminger, Clemens Ruppert, Carolin Pucker, Werner Seeger, Andreas Günther, Philipp Markart, Jörg Stürzebecher
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 28:95-102
Conversion of the biophysically active large surfactant aggregate subtype (LA) of alveolar surfactant into the less surface active small surfactant aggregates (SA) occurs in vivo and is reproduced under conditions of cyclic surface area changes in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31c1223fa90283904b0d27722de2e38
https://doi.org/10.1165/rcmb.4591
https://doi.org/10.1165/rcmb.4591
Publikováno v:
Thrombosis Research. 109:145-151
Introduction : The exchange of Aα 16, Arg for Cys or His is the most common molecular defect in dysfibrinogenemia directly affecting the thrombin cleavage site involved in fibrinopeptide A (FPA) release. Other amino acid exchanges within the fibrino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8df093f210efd140668b68e67cbd7f7
https://doi.org/10.1016/s0049-3848(03)00114-2
https://doi.org/10.1016/s0049-3848(03)00114-2