Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jörg Rinnenthal"'
Autor:
Xiaoguang, Hao, Ravinder, Bahia, Orsolya, Cseh, Danielle, Bozek, Sophia, Blake, Jörg, Rinnenthal, Ulrike, Weyer-Czernilofsky, Dorothea, Rudolph, H Artee, Luchman
Publikováno v:
Neuro-Oncology. 25:913-926
Background The tumor suppressor TP53 (p53) is frequently mutated, and its downstream effectors inactivated in many cancers, including glioblastoma (GBM). In tumors with wild-type status, p53 function is frequently attenuated by alternate mechanisms i
Autor:
Andreas Mantoulidis, Daniel Gerlach, Matthias Treu, Jörg Rinnenthal, Irene Waizenegger, Heribert Arnhof, Joachim Broeker, Jason Phan, Alex G. Waterson, Stephan W. Fesik, Jesse J. Lipp, Fabio Savarese, Annette Machado, Hengyu Lu, Norbert Kraut, Christian Smethurst, Darryl B. McConnell, Mark Petronczki, Timothy P. Heffernan, Michael Gmachl, Francesca Trapani, Andreas Gollner, Joseph R. Daniele, Joseph R. Marszalek, Dorothea Rudolph, Christopher P. Vellano, Peter Ettmayer, Johannes Popow, Marco H. Hofmann
Publikováno v:
Cancer Research. 81:1271-1271
KRASG12C mutations are predominantly found in non-small cell lung cancer (NSCLC, 13%), in colorectal cancer (CRC, 3%), and with a lower prevalence in pancreatic ductal adenocarcinoma (PDAC, 1%). The amino acid exchange at position 12 from glycine to
Autor:
Andreas Schrenk, Daniela Häring, Silke Fischer, Stefan Kornigg, Alex G. Waterson, Andreas Mantoulidis, Manfred Koegl, Markus Zeeb, Thomas Gerstberger, Mark Pearson, Wolfgang Hela, Andreas Zoephel, Darryl B. McConnell, Michael Gmachl, Bernadette Sharps, Jale Karolyi-Oezguer, Johann Hoffmann, Franziska Moser, Jason Phan, Teresa Gmaschitz, David Covini, Bernhard Wolkerstorfer, Qi Sun, Lyne Lamarre, Gabriella Siszler, Renate Schnitzer, Moriz Mayer, Dirk Kessler, Katharina Schipany, Petr Knesl, Christian Salamon, Peter Greb, Stephen W. Fesik, Andreas Gollner, Yvonne Scherbantin, Silvia Munico-Martinez, Craig M. Goodwin, Roland Kousek, Jörg Rinnenthal, Jiqing Sai, Christoph Peinsipp, Laetitia J. Martin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Despite decades of research, no approved drugs have been discovered for KRAS. Recently, a pocket occurring on the surface of the active and inactive form of KRAS was found, but, due to its comparatively shallow, polar nature, this pocket
Autor:
Caterina Missero, Satrajit Sinha, Christian Osterburg, Marco Ferniani, Anna Sirico, Claudia Russo, Sebastian Kehrloesser, Dario Antonini, Birgit Schäfer, Raffaele Ambrosio, Jörg Rinnenthal, Peter Güntert, Julia M. Würz, Volker Dötsch
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 115 (5)
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
The p63 gene encodes a master regulator of epidermal commitment, development, and differentiation. Heterozygous mutations in the C-terminal domain of the p63 gene can cause ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome, a life-th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3d0c7af049e664ab6a9939e41007b0
https://www.repository.cam.ac.uk/handle/1810/279044
https://www.repository.cam.ac.uk/handle/1810/279044
Publikováno v:
Nucleic Acids Research
The cyanobacterial hsp17 ribonucleicacid thermometer (RNAT) is one of the smallest naturally occurring RNAT. It forms a single hairpin with an internal 1×3-bulge separating the start codon in stem I from the ribosome binding site (RBS) in stem II. W
Autor:
Hema Artee Luchman, Sophia Blake, Dorothea Rudolph, Samuel Weiss, Danielle Bozek, Xiaoguang Hao, Jörg Rinnenthal
Publikováno v:
Cancer Research. 79:3084-3084
Glioblastoma (GBM) is characterized by an aggressive clinical course, therapeutic resistance and striking molecular heterogeneity. GBM remains incurable with a median survival of 12-15 months post-surgery even with standard of care chemotherapy and r
Autor:
Martina Sykora, Dorothea Rudolph, Ulrike Weyer-Czernilofsky, Gabriela Gremel, Andreas Wernitznig, Sophia Blake, Markus Reschke, Jörg Rinnenthal, Andreas Gollner, Norbert Kraut, Jürgen Moll
Publikováno v:
Cancer Research. 79:3197-3197
MDM2-p53 antagonists block the interaction between the Tumor Protein p53 and MDM2, its key negative regulator, and represent a new therapeutic concept for cancer therapy. MDM2-p53 antagonists are designed to restore p53 activity in TP53 wild-type tum
Autor:
Vittoria Zinzalla, Barbara Drobits-Handl, Alexander Savchenko, Jörg Rinnenthal, Markus Johann Bauer, Michael Sanderson, Sophia Maria Blake, Norbert Schweifer, Robert Gerhardus Jacob Vries, Hans Clevers, Norbert Kraut
Publikováno v:
Cancer Research. 79:DDT01-01
Aberrant Wnt/β-catenin signalling has been shown to play a key role in tumorigenesis and resistance to immunotherapy in several tumor indications. Wnt ligand-mediated signals are transduced by two distinct receptor types, the serpentine receptor Fri
Publikováno v:
Biophysical Journal. 102:2564-2574
In this study, we have optimized NMR methodology to determine the thermodynamic parameters of basepair opening in DNA and RNA duplexes by characterizing the temperature dependence of imino proton exchange rates of individual basepairs. Contributions
Publikováno v:
Nucleic Acids Research
RNA thermometers are translational control elements that regulate the expression of bacterial heat shock and virulence genes. They fold into complex secondary structures that block translation at low temperatures. A temperature increase releases the