Zobrazeno 1 - 10
of 203
pro vyhledávání: '"Jörg Rademann"'
Autor:
Umer Bin Abdul Aziz, Ali Saoud, Marcel Bermudez, Maren Mieth, Amira Atef, Thomas Rudolf, Christoph Arkona, Timo Trenkner, Christoph Böttcher, Kai Ludwig, Angelique Hoelzemer, Andreas C. Hocke, Gerhard Wolber, Jörg Rademann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Pneumolysin (PLY) is a cholesterol-dependent cytolysin (CDC) from Streptococcus pneumoniae, the main cause for bacterial pneumonia. Liberation of PLY during infection leads to compromised immune system and cytolytic cell death. Here, we repo
Externí odkaz:
https://doaj.org/article/d115b78ddffa4616af6f6aa528f3f42c
Autor:
Umer Bin Abdul Aziz, Ali Saoud, Marcel Bermudez, Maren Mieth, Amira Atef, Thomas Rudolf, Christoph Arkona, Timo Trenkner, Christoph Böttcher, Kai Ludwig, Angelique Hoelzemer, Andreas C. Hocke, Gerhard Wolber, Jörg Rademann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/a9c589d94a30489c8d0d88a9d47ad5a8
Autor:
Claudia Damaris Müller, Gloria Ruiz-Gómez, Sophie Cazzonelli, Stephanie Möller, Robert Wodtke, Reik Löser, Joanna Freyse, Jan-Niklas Dürig, Jörg Rademann, Ute Hempel, M. Teresa Pisabarro, Sarah Vogel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Transglutaminases (TGs) catalyze the covalent crosslinking of proteins via isopeptide bonds. The most prominent isoform, TG2, is associated with physiological processes such as extracellular matrix (ECM) stabilization and plays a crucial rol
Externí odkaz:
https://doaj.org/article/ec1ce90abb794cc0b3ccdc64ff3a478e
Autor:
Claudia Damaris Müller, Gloria Ruiz-Gómez, Sophie Cazzonelli, Stephanie Möller, Robert Wodtke, Reik Löser, Joanna Freyse, Jan-Niklas Dürig, Jörg Rademann, Ute Hempel, M. Teresa Pisabarro, Sarah Vogel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/3a52a3cf3ee5429eb426bbaf548003d3
Autor:
Ee Lin Wong, Eric Nawrotzky, Christoph Arkona, Boo Geun Kim, Samuel Beligny, Xinning Wang, Stefan Wagner, Michael Lisurek, Dirk Carstanjen, Jörg Rademann
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
The oncogene STAT5 is involved in cancer cell proliferation. Here, the authors use STAT5 protein to assemble its own small molecule inhibitors via Mannich ligation (three-component-reactions) and show that the resultant ligands can inhibit the prolif
Externí odkaz:
https://doaj.org/article/2011251d4c4d4f39bd08fae3a0b285a3
Autor:
Linda Koehler, Sergey Samsonov, Sandra Rother, Sarah Vogel, Sebastian Köhling, Stephanie Moeller, Matthias Schnabelrauch, Jörg Rademann, Ute Hempel, M. Teresa Pisabarro, Dieter Scharnweber, Vera Hintze
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Glycosaminoglycans are known to bind biological mediators thereby modulating their biological activity. Sulfated hyaluronans (sHA) were reported to strongly interact with transforming growth factor (TGF)-β1 leading to impaired bioactivity i
Externí odkaz:
https://doaj.org/article/c04d4419433f40119e66c264da1ea33c
Autor:
Daniel Becker, Zuzanna Kaczmarska, Christoph Arkona, Robert Schulz, Carolin Tauber, Gerhard Wolber, Rolf Hilgenfeld, Miquel Coll, Jörg Rademann
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Molecular fragments are useful tools in drug-discovery but they might be hard to identify due to their weak affinity to the targets. Here, the authors use a protein-templated assembly to design high affinity inhibitors of Coxsackie virus 3C protease,
Externí odkaz:
https://doaj.org/article/a53d99ca5b15420c94025185b9b89835
Publikováno v:
FEBS Open Bio, Vol 9, Iss 12, Pp 2174-2174 (2019)
Externí odkaz:
https://doaj.org/article/c381a4a7813147d7b23242d9fd5ffdad
Autor:
Jörg Rademann
Publikováno v:
Proceedings, Vol 22, Iss 1, p 110 (2019)
Fragment-based drug discovery has been established as a powerful method for the assembly ofoptimized protein ligands [...]
Externí odkaz:
https://doaj.org/article/ce86f9739aba4c49aab787ffd39c30fa
Autor:
Katharina Koschek, Vedat Durmaz, Oxana Krylova, Marek Wieczorek, Shilpi Gupta, Martin Richter, Alexander Bujotzek, Christina Fischer, Rainer Haag, Christian Freund, Marcus Weber, Jörg Rademann
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 11, Iss 1, Pp 837-847 (2015)
Three polymers, poly(N-(2-hydroxypropyl)methacrylamide) (pHPMA), hyperbranched polyglycerol (hPG), and dextran were investigated as carriers for multivalent ligands targeting the adaptive tandem WW-domain of formin-binding protein (FBP21). Polymer ca
Externí odkaz:
https://doaj.org/article/c374aa3a28494ccc9e4db5c0b9399341