Zobrazeno 1 - 10
of 275
pro vyhledávání: '"Jörg Pietruszka"'
Autor:
Flaminia Mazzone, Moritz K. T. Klischan, Julian Greb, Sander H. J. Smits, Jörg Pietruszka, Klaus Pfeffer
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
Toxoplasmosis is a zoonotic disease caused by Toxoplasma gondii, an apicomplexan parasite that infects approximately a third of the world’s human population. This disease can cause serious complications during pregnancy and can be fatal in immunoco
Externí odkaz:
https://doaj.org/article/6cc11104dc5b4666968309a56f7a9d1c
Autor:
Moritz K. T. Klischan, Flaminia Mazzone, Lena Berning, Julian Greb, Max Schlamkow, Mona Haase, Wolfgang Frey, Björn Stork, Klaus Pfeffer, Jörg Pietruszka
Publikováno v:
ACS Omega, Vol 8, Iss 44, Pp 41816-41834 (2023)
Externí odkaz:
https://doaj.org/article/cc5f9bbe71904adabd1f20de09ffe966
Autor:
Lena Berning, Thomas Lenz, Ann Kathrin Bergmann, Gereon Poschmann, Hannah U. C. Brass, David Schlütermann, Annabelle Friedrich, María José Mendiburo, Céline David, Seda Akgün, Jörg Pietruszka, Kai Stühler, Björn Stork
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-24 (2023)
Abstract Background The bacterial secondary metabolite prodigiosin has been shown to exert anticancer, antimalarial, antibacterial and immunomodulatory properties. With regard to cancer, it has been reported to affect cancer cells but not non-maligna
Externí odkaz:
https://doaj.org/article/7ecfe60b57124e5b8a217be3a9ae7907
Publikováno v:
Frontiers in Catalysis, Vol 3 (2023)
Introduction: The antimicrobial pyrrolnitrin from Pseudomonas strains is formed in four steps from tryptophan and comprises two flavin-dependent halogenases. Both PrnC and PrnA can carry out regioselective chlorination and bromination and are carrier
Externí odkaz:
https://doaj.org/article/33b9ab909e0347518112d0e43425aeb7
Autor:
Fabienne Hilgers, Fabian Hogenkamp, Oliver Klaus, Luzie Kruse, Anita Loeschcke, Claus Bier, Dennis Binder, Karl-Erich Jaeger, Jörg Pietruszka, Thomas Drepper
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Photocaged inducer molecules, especially photocaged isopropyl-β-d-1-thiogalactopyranoside (cIPTG), are well-established optochemical tools for light-regulated gene expression and have been intensively applied in Escherichia coli and other bacteria i
Externí odkaz:
https://doaj.org/article/8a77a37d6472492bbb61a8f9f39416a0
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 491-496 (2021)
For more than two decades, the development of potent acetylcholinesterase (AChE) inhibitors has been an ongoing task to treat dementia associated with Alzheimer’s disease and improve the pharmacokinetic properties of existing drugs. In the present
Externí odkaz:
https://doaj.org/article/4a15ed8510784a0aa533113758714a39
Autor:
Sebastian Kruth, Cindy J.-M. Zimmermann, Katharina Kuhr, Wolf Hiller, Stephan Lütz, Jörg Pietruszka, Marcel Kaiser, Markus Nett
Publikováno v:
Molecules, Vol 28, Iss 3, p 1066 (2023)
The natural product aurachin D is a farnesylated quinolone alkaloid, which is known to possess activity against the causative agent of malaria, Plasmodium spp. In this study, we show that aurachin D inhibits other parasitic protozoa as well. While au
Externí odkaz:
https://doaj.org/article/7a8eca9b31ec47208e68c58cc734bdd5
Autor:
Nicola Porta, Alexander Veljko Fejzagić, Kathryn Dumschott, Beatrix Paschold, Björn Usadel, Jörg Pietruszka, Thomas Classen, Holger Gohlke
Publikováno v:
Catalysts, Vol 12, Iss 10, p 1195 (2022)
Halogenating enzymes have evolved in considerable mechanistic diversity. The apparent need for secondary metabolism coincides with the current need to introduce halogens in synthetic products. The potential of halogenating enzymes and, especially, va
Externí odkaz:
https://doaj.org/article/547797ec1ab544acb4ce0f568f8d8446
Publikováno v:
Molecules, Vol 27, Iss 19, p 6483 (2022)
Enzyme immobilization is a technology that enables (bio-)catalysts to be applied in continuous-flow systems. However, there is a plethora of immobilization methods available with individual advantages and disadvantages. Here, we assessed the influenc
Externí odkaz:
https://doaj.org/article/e96adb8b2a7a4123a6902341656af750
Autor:
Alina Kinner, Philipp Nerke, Regine Siedentop, Till Steinmetz, Thomas Classen, Katrin Rosenthal, Markus Nett, Jörg Pietruszka, Stephan Lütz
Publikováno v:
Biomedicines, Vol 10, Iss 5, p 964 (2022)
Biocatalysis is constantly providing novel options for the synthesis of active pharmaceutical ingredients (APIs). In addition to drug development and manufacturing, biocatalysis also plays a role in drug discovery and can support many active ingredie
Externí odkaz:
https://doaj.org/article/ced19109aa7f4727916473fcec86ad77